NCT04195399 2026-04-15
A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery
Children's Oncology Group
Phase 2 Active not recruiting
Clinical Trials
9 trialsNCT07170644 2026-04-06
A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF)
SpringWorks Therapeutics, Inc.
Phase 2 Active not recruiting
NCT07176689 2026-04-06
Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)
SpringWorks Therapeutics, Inc.
Phase 4 Recruiting
NCT05041036 2026-04-01
Individual Patient Compassionate Use of Nirogacestat
SpringWorks Therapeutics, Inc.
Available
NCT05949099 2025-09-08
Study of Cryoablation and Nirogacestat for Desmoid Tumor
Stanford University
Phase 2 Recruiting
NCT03785964 2025-01-31
DeFi
SpringWorks Therapeutics, Inc.
Phase 3 Completed
NCT01981551 2024-02-06
Phase II Trial of the Gamma-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors/Aggressive Fibromatosis
National Institutes of Health Clinical Center (CC)
Phase 2 Completed
NCT02955446 2019-02-01
Compassionate Use Protocol for PF-03084014 in Patients With Advanced Solid Tumor Malignancies
University of Colorado, Denver
No longer available
NCT02137564 2015-07-23
Gamma Secretase Inhibitor PF-03084014 in Treating Patients With AIDS-Associated Kaposi Sarcoma
AIDS Malignancy Consortium
Phase 2 Withdrawn