Announcements Trials
Browse Landscape

Phase

Phase 2 2Phase 1 2Phase 3 1

Status

Completed 5Withdrawn 1

Sponsor Class

INDUSTRY 5

Study Type

Interventional 5

Sponsor

Cancer Type

Sarcoma 5Lymphoid 5Gynecologic 5Breast 5CNS 3Tumor-Agnostic 2Plasma cell 2Other solid neoplasm 2Genitourinary 2Other hematologic neoplasm 1Myeloid 1

Conditions

Sarcoma 4Osteosarcoma 1Neoplasms 1Neoplasm Metastasis 1Liposarcoma 1Leiomyosarcoma 1Gliosarcoma 1Glioma 1Glioblastoma 1Bone Neoplasms 1

Interventions

Radiotherapy 144Doxorubicin 112Temozolomide 110Cyclophosphamide 110Filgrastim 79Ifosfamide 70Imatinib Mesylate 69Etoposide 69Bevacizumab 55Vincristine 51Gemcitabine 50Peripheral Blood Stem Cell Transplantation 47Irinotecan 43Methotrexate 39Cisplatin 36Carboplatin 36Radiation 35fludarabine phosphate 34Busulfan 34pazopanib 32Sirolimus 30Melphalan 30Trabectedin 29Docetaxel 27Chemotherapy, Adjuvant 27Cyclosporine 25Carmustine 25sargramostim 24Surgical Procedures, Operative 23Sunitinib 23

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Completed × ridaforolimus × Sarcoma × Clear all
NCT00087451 2015-08-19

Safety Study of AP23573 in Patients With Progressive or Recurrent Glioma (8669-023)(COMPLETED)

Merck Sharp & Dohme LLC

Phase 1 Completed
11 enrolled
CNSSarcoma

Glioblastoma, Glioma, Gliosarcoma

NCT00288431 2015-07-22

Safety, Tolerability and Maximum Tolerated Dose of Oral AP23573 in Combination With Doxorubicin (8669-015)

Merck Sharp & Dohme LLC

Phase 1 Completed
37 enrolled
Sarcoma

Neoplasms, Sarcoma

NCT01010672 2015-04-30

Phase II Study of Ridaforolimus (MK-8669) With Metastatic Bone or Soft-tissue Sarcoma Patients (MK-8669-030 AM1)

Merck Sharp & Dohme LLC

Phase 2 Completed
50 enrolled
Sarcoma

Sarcoma

NCT00093080 2015-02-13

Study of AP23573/MK-8669 (Ridaforolimus), A Mammalian Target of Rapamycin (mTOR) Inhibitor, in Participants With Advanced Sarcoma (MK-8669-018 AM1)(COMPLETED)

Merck Sharp & Dohme LLC

Phase 2 Completed
216 enrolled
Sarcoma

Leiomyosarcoma, Liposarcoma, Neoplasm Metastasis, Sarcoma, Osteosarcoma

NCT00538239 2015-02-13

SUCCEED

Merck Sharp & Dohme LLC

Phase 3 Completed
711 enrolled
Sarcoma

Bone Neoplasms, Sarcoma

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