Announcements Trials
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Phase

Phase 1 6Phase 2 3Phase 1/2 2Phase 2/3 1

Status

Completed 3Withdrawn 1Unknown 1Active not recruiting 1

Sponsor Class

OTHER 4NIH 1INDUSTRY 1

Study Type

Interventional 6

Sponsor

Cancer Type

Other hematologic neoplasm 13Lymphoid 10Plasma cell 7Sarcoma 6Gastrointestinal 5Myeloid 4Dermatologic 4CNS 4Gynecologic 3Thoracic 1Other solid neoplasm 1Genitourinary 1Breast 1

Conditions

Sarcoma 5Neurofibrosarcoma 2Sarcoma, Ewing 1Sarcoma, Endometrial Stromal 1Sarcoma, Alveolar Soft Part 1Liposarcoma 1Leiomyosarcoma 1Gliosarcoma 1Glioblastoma 1Bone Neoplasms 1

Interventions

Temozolomide 62Cyclophosphamide 60Radiotherapy 48Doxorubicin 36Filgrastim 26Radiation 24Irinotecan 24fludarabine 23Gemcitabine 23Magnetic Resonance Spectroscopy 21Imatinib Mesylate 19Etoposide 18pembrolizumab 16Cisplatin 15Carboplatin 15Biopsy 15Bevacizumab 15Specimen Handling 14fludarabine phosphate 12Nivolumab 12Leucovorin 12Ipilimumab 12Granulocyte Colony-Stimulating Factor 12Chemotherapy, Adjuvant 12pazopanib 11Vincristine 11Ifosfamide 11Melphalan 10Erlotinib Hydrochloride 10Docetaxel 10

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

6 trials
RecentStart dateEnrollment
Phase 1 × selinexor × Sarcoma × Clear all
NCT04216329 2026-01-23

Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma

National Institutes of Health Clinical Center (CC)

Phase 1 Active not recruiting
11 enrolled 19 charts
CNSSarcoma

Glioblastoma, Gliosarcoma

NCT04811196 2025-05-29

A Study of Different Dosing Schedules of Selinexor in Sarcoma Patients

University Health Network, Toronto

Phase 1 Completed
56 enrolled
GynecologicSarcoma

Leiomyosarcoma, Sarcoma, Sarcoma, Endometrial Stromal, Neurofibrosarcoma

NCT04595994 2024-01-23

SeliSarc

Grupo Espanol de Investigacion en Sarcomas

Phase 1 Unknown
14 enrolled
Sarcoma

Sarcoma

NCT01896505 2024-01-08

A Phase I Trial to Assess the Effects of Food and Formulation on PK of KPT-330 in Patients With Sarcoma

Karyopharm Therapeutics Inc

Phase 1 Completed
54 enrolled 28 charts
Sarcoma

Bone Neoplasms, Sarcoma

NCT03042819 2021-12-09

Study of Selinexor and Doxorubicin in Advanced Soft Tissue Sarcomas

University Health Network, Toronto

Phase 1 Completed
25 enrolled
Sarcoma

Sarcoma

NCT03880123 2020-11-27

Selinexor in Combination With Ixazomib for the Treatment of Advanced Sarcoma

Columbia University

Phase 1 Withdrawn
Sarcoma

Liposarcoma, Sarcoma, Sarcoma, Ewing, Sarcoma, Alveolar Soft Part, Neurofibrosarcoma

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