Announcements Trials
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Phase

Phase 1 1

Status

Terminated 1

Sponsor Class

INDUSTRY 1

Study Type

Interventional 1

Sponsor

Cancer Type

Thoracic 1Dermatologic 1CNS 1

Conditions

Carcinoma, Non-Small-Cell Lung 16Lung Neoplasms 11Melanoma 4Neoplasm Metastasis 3Colorectal Neoplasms 3Thyroid Neoplasms 2Pancreatic Neoplasms 2Neoplasms 2Hematologic Neoplasms 2Glioma 2Adenocarcinoma of Lung 2Uterine Neoplasms 1Uterine Cervical Neoplasms 1Urinary Bladder Neoplasms 1Thyroid Diseases 1Stomach Neoplasms 1Solid Tumor 1Recurrence 1Rectal Neoplasms 1Prostatic Neoplasms 1Ovarian Neoplasms 1Noonan Syndrome 5 1Neurofibromatosis 1 1Multiple Myeloma 1Lymphoma 1Leukemia, Myeloid, Acute 1Hereditary Sensory and Autonomic Neuropathies 1Esophageal Neoplasms 1Endometrial Neoplasms 1Disease Progression 1

Interventions

Paclitaxel 3Carboplatin 3selpercatinib 2Radiotherapy 2Cisplatin 2regorafenib 1pentetreotide 1pembrolizumab 1glutathione pegylated liposomal doxorubicin 1etoposide phosphate 1carboxyamido-triazole 1budigalimab 1binimetinib 1aflibercept 1Trastuzumab 1Temozolomide 1Taxes 1Tamoxifen 1Quality of Life 1Peripheral Blood Stem Cell Transplantation 1Patient Reported Outcome Measures 1PF-07284890 1Nivolumab 1NEO212 1Molecular Diagnostic Techniques 1Midazolam 1Levofloxacin 1Lapatinib 1Ipilimumab 1Immunotherapy 1

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
Central Nervous System Neoplasms × binimetinib × Thoracic × Clear all
NCT04543188 2025-10-23

A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement

Pfizer

Phase 1 Terminated
65 enrolled 52 charts
CNSDermatologicThoracic

Brain Diseases, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasms, Central Nervous System Neoplasms

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