Announcements Trials
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Phase

Phase 1/2 1Phase 1 1

Status

Recruiting 20Completed 12Terminated 8Not yet recruiting 2Active not recruiting 2Unknown 1Enrolling by invitation 1

Sponsor Class

INDUSTRY 2

Study Type

Interventional 2

Sponsor

Cancer Type

Gastrointestinal 37Head & Neck 4Thoracic 2Dermatologic 2Breast 2Sarcoma 1Other solid neoplasm 1NET 1Gynecologic 1Genitourinary 1Endocrine 1CNS 1

Conditions

Carcinoma, Non-Small-Cell Lung 551Lung Neoplasms 313Small Cell Lung Carcinoma 87Colorectal Neoplasms 71Melanoma 68Breast Neoplasms 60Neoplasms 55Ovarian Neoplasms 47Neoplasm Metastasis 45Carcinoma, Renal Cell 45Squamous Cell Carcinoma of Head and Neck 43Pancreatic Neoplasms 39Stomach Neoplasms 37Triple Negative Breast Neoplasms 31Head and Neck Neoplasms 30Esophageal Neoplasms 28Endometrial Neoplasms 25Prostatic Neoplasms 24Uterine Cervical Neoplasms 23Urinary Bladder Neoplasms 23Brain Neoplasms 22Colonic Neoplasms 21Mesothelioma 20Mesothelioma, Malignant 18Carcinoma, Hepatocellular 18Sarcoma 16Carcinoma, Transitional Cell 15Adenocarcinoma of Lung 15Lung Diseases 14NSCLC 13

Interventions

obinutuzumab 1naptumomab estafenatox 1durvalumab 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Active not recruiting × Esophageal Squamous Cell Carcinoma × Thoracic × Clear all
NCT04140500 2026-03-18

Dose Escalation Study of a PD1-LAG3 Bispecific Antibody in Patients With Advanced and/or Metastatic Solid Tumors

Hoffmann-La Roche

Phase 1/2 Active not recruiting
170 enrolled
DermatologicGastrointestinalThoracic

Esophageal Squamous Cell Carcinoma, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT03983954 2025-11-28

Naptumomab Estafenatox in Combination With Durvalumab in Subjects With Selected Advanced or Metastatic Solid Tumor, Including a Cohort Expansion in Esophageal Cancer.

NeoTX Therapeutics Ltd.

Phase 1 Active not recruiting
120 enrolled
BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

Adenocarcinoma Of Esophagus, Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Urinary Bladder Neoplasms, Carcinoma, Renal Cell, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma, Mesothelioma, Ovarian Neoplasms, Prostatic Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

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