Clinical Trials

453 enrolled

LymphoidThoracic

Lymphoma, Follicular, Recurrence, Small Cell Lung Carcinoma

NCT07277413 2026-04-03

A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

GastrointestinalGenitourinaryOther solid neoplasmThoracic

260 enrolled

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Mesothelioma, Malignant, Urinary Bladder Neoplasms, Carcinoma, Transitional Cell, Mesothelioma, Neoplasm Metastasis, Recurrence

NCT05815160 2026-03-30

Debio 0123 in Combination With Carboplatin and Etoposide in Adult Participants With Small Cell Lung Cancer That Recurred or Progressed After Previous Standard Platinum-Based Therapy

Phase 1 Active not recruiting

34 enrolled

Recurrence, Small Cell Lung Carcinoma

NCT05283330 2026-03-20

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

BreastCNSGastrointestinalGenitourinaryGynecologicThoracic

48 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Colonic Neoplasms, Glioblastoma, Neoplasm Metastasis, Prostatic Neoplasms, Recurrence, Colorectal Neoplasms

NCT05537740 2026-03-20

A First-in-human Study to Learn How Safe the Study Drug BAY3375968, an Anti-CCR8 Antibody, is, When Given Alone or in Combination With Pembrolizumab, How it Affects the Body, How it Moves Into, Through, and Out of the Body, and to Find the Best Dose in Participants With Advanced Solid Tumors

Phase 1 Active not recruiting

129 enrolled

BreastDermatologicHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Melanoma, Recurrence, Triple Negative Breast Neoplasms

NCT07480213 2026-03-18

DART-NK-SCLC

Phase 1/2 Recruiting

60 enrolled

GastrointestinalGynecologicOther solid neoplasmThoracic

Recurrence, Small Cell Lung Carcinoma

NCT06051695 2026-02-20

EVEREST-2

Phase 1/2 Recruiting

474 enrolled

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Recurrence, Colorectal Neoplasms

NCT05150691 2026-01-28

A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors

Phase 1/2 Recruiting

796 enrolled

BreastGastrointestinalGynecologicThoracic

Bile Duct Neoplasms, Biliary Tract Neoplasms, Breast Neoplasms, Carcinoma, Carcinoma, Non-Small-Cell Lung, Gastrointestinal Neoplasms, Liver Neoplasms, Neoplasm Metastasis, Neoplasms, Recurrence, Stomach Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma

NCT04777994 2025-12-23

Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

GenitourinaryHead & NeckThoracic

248 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Neoplasms, Recurrence

NCT06922539 2025-12-15

ST-001 nanoFenretinide in Relapsed/ Refractory Small Cell Lung Cancer

44 enrolled

Recurrence, Small Cell Lung Carcinoma

NCT05253807 2025-08-05

FIGHT-210

8 enrolled 13 charts

CNSGastrointestinalHead & NeckThoracic

Acrocephalosyndactylia, Carcinoma, Non-Small-Cell Lung, Recurrence

NCT06872489 2025-07-23

Expanded Access Protocol for the Use of SL-28 in the Treatment of Advanced Solid Tumors

Available

Carcinoma, Non-Small-Cell Lung, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Neuroblastoma, Pancreatic Neoplasms, Recurrence

NCT05274451 2025-07-01

A Study to Investigate LYL797 in Adults With Solid Tumors

BreastGynecologicThoracic

57 enrolled

Carcinoma, Ovarian Epithelial, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Fallopian Tube Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Recurrence, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT05573035 2025-07-01

A Study to Investigate LYL845 in Adults With Solid Tumors

DermatologicGastrointestinalThoracic

39 enrolled

Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasm Metastasis, Recurrence, Colorectal Neoplasms

NCT05891197 2025-07-01

START

Terminated

10 enrolled

BreastGynecologicThoracic

NCT02029729 2025-05-29

DISCOVER

Phase 1/2 Active not recruiting

11 enrolled

DermatologicThoracic

Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasm Metastasis, Recurrence

NCT05736731 2025-04-25

EVEREST-1

160 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Neoplasms, Pancreatic Neoplasms, Recurrence, Colorectal Neoplasms

NCT05275673 2025-04-24

A Study of Sapanisertib in Relapsed/Refractory NFE2L2-Mutated and Wild-Type Squamous Non-Small Cell Lung Cancer

7 enrolled 11 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Recurrence

NCT05631574 2025-02-07

Study of Covalent Menin Inhibitor BMF-219 in Adult Patients With KRAS Driven Non-Small Cell Lung Cancer, Pancreatic Cancer, and Colorectal Cancer

Other solid neoplasmThoracic

13 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms, Recurrence, Colorectal Neoplasms

NCT05324436 2025-01-20

A Study of Yervoy and Opdivo Combination Therapy in Participants With Unresectable Advanced/Recurrent Malignant Pleural Mesothelioma (MPM)

Completed

75 enrolled

Mesothelioma, Malignant, Recurrence

NCT04855929 2024-11-08

ANV419-001

55 enrolled

Disease, Lung Neoplasms, Neoplasms, Recurrence

NCT04795713 2024-11-04

Study of MT-6402 in Subjects With Advanced Solid Cancer That Expresses PD-L1

BreastGastrointestinalGynecologicSarcomaThoracic

64 enrolled

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Recurrence

NCT03345485 2024-10-21

EDO-S101

Phase 1/2 Completed

71 enrolled 39 charts

Breast Neoplasms, Fallopian Tube Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Recurrence, Sarcoma, Endometrial Neoplasms, Gastrointestinal Stromal Tumors, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT05861947 2024-01-31

JIVAN

Phase 1 Unknown

30 enrolled

GastrointestinalGenitourinaryThoracic

Carcinoma, Non-Small-Cell Lung, Carcinoma, Transitional Cell, Colonic Neoplasms, Esophageal Neoplasms, Kidney Neoplasms, Recurrence, Stomach Neoplasms

NCT03330405 2023-10-13

Javelin Parp Medley: Avelumab Plus Talazoparib In Locally Advanced Or Metastatic Solid Tumors

Phase 1/2 Terminated

223 enrolled 50 charts

BreastGynecologicThoracic

Carcinoma, Ovarian Epithelial, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Recurrence

NCT03805841 2023-06-28

RAIN

41 enrolled 12 charts

BreastGastrointestinalGynecologicThoracic

Carcinoma, Non-Small-Cell Lung, Recurrence

NCT00248404 2022-05-16

NB1011 Administered by Continuous Infusion in Cancers That Overexpress Thymidylate Synthase (TS)

Phase 1/2 Completed

155 enrolled

Breast Neoplasms, Lung Neoplasms, Neoplasms, Ovarian Neoplasms, Recurrence, Colorectal Neoplasms

NCT02460367 2022-04-06

Immunotherapy Combination Study in Advanced Previously Treated Non-Small Cell Lung Cancer

16 enrolled

Carcinoma, Non-Small-Cell Lung, Recurrence

NCT02674568 2021-07-30

TRINITY

342 enrolled 18 charts

BreastGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

Recurrence, Small Cell Lung Carcinoma

NCT04464967 2021-05-12

Safety and Preliminary Efficacy of SNK01 in Combination With Trastuzumab or Cetuximab in Subjects With Advanced HER2 or EGFR Cancers

Phase 1/2 Withdrawn

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Recurrence, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT03538028 2020-10-30

A Safety and Tolerability Study of INCAGN02385 in Select Advanced Malignancies

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther solid neoplasmThoracic

22 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma, Mesothelioma, Neoplasm Metastasis, Ovarian Neoplasms, Recurrence, Stomach Neoplasms, Carcinoma, Merkel Cell, Lymphoma, Large B-Cell, Diffuse, Microsatellite Instability, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT02147990 2020-08-12

NSCLC

318 enrolled 29 charts

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Neoplasms, Recurrence

NCT01526928 2020-08-04

Study to Evaluate Safety, Pharmacokinetics, and Efficacy of Rociletinib (CO-1686) in Previously Treated Mutant Epidermal Growth Factor Receptor (EGFR) in Non-Small Cell Lung Cancer (NSCLC) Patients

Phase 1/2 Terminated

612 enrolled 34 charts

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Neoplasms, Recurrence

NCT01774578 2020-05-28

Immunotherapy Study in Progressive or Relapsed Non-Small Cell Lung Cancer

Phase 2/3 Terminated

135 enrolled

Carcinoma, Non-Small-Cell Lung, Recurrence

NCT01478685 2019-11-12

A Phase 1 Study of CC-486 as a Single Agent and in Combination With Carboplatin or ABI-007 in Subjects With Relapsed or Refractory Solid Tumors

GastrointestinalGenitourinaryGynecologicThoracic

169 enrolled

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Transitional Cell, Fallopian Tube Neoplasms, Ovarian Neoplasms, Peritoneal Neoplasms, Recurrence, Tumor Virus Infections, Carcinoma, Pancreatic Ductal

NCT02322281 2019-08-14

TIGER-3: Open Label, Multicenter Study of Rociletinib (CO-1686) Mono Therapy Versus Single-agent Cytotoxic Chemotherapy in Patients With Mutant EGFR NSCLC Who Have Failed at Least One Previous EGFR-Directed TKI and Platinum-doublet Chemotherapy

Phase 3 Terminated

149 enrolled 17 charts

GastrointestinalGynecologicThoracic

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Neoplasms, Recurrence

NCT01040312 2019-05-23

An Observational Study of CPT-11 Plus Platinum Analogues Regimens and UGT1A1 Genotypes in Solid Tumors

Completed

321 enrolled

Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Ovarian Neoplasms, Recurrence, Stomach Neoplasms, Small Cell Lung Carcinoma

NCT02186301 2019-05-07

EGFR

Phase 2/3 Terminated

100 enrolled 14 charts

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Neoplasms, Recurrence

NCT02346370 2019-02-08

PRIMAL

16 enrolled 12 charts

Carcinoma, Non-Small-Cell Lung, Recurrence

NCT02323854 2018-05-07

EMPRESS

Phase NA Completed

15 enrolled 10 charts

Lung Neoplasms, Recurrence

NCT02100007 2017-10-02

ME-344 Given in Combination With Hycamtin® in Patients With Solid Tumors

Phase 1/2 Terminated

46 enrolled 17 charts

GynecologicThoracic

Neoplasm Metastasis, Ovarian Neoplasms, Recurrence, Small Cell Lung Carcinoma

NCT00597116 2016-10-10

An Efficacy and Safety Study With Vandetanib to Treat Inoperable or Relapsed Malignant Mesothelioma

Other solid neoplasmThoracic

25 enrolled 8 charts

Mesothelioma, Recurrence

NCT01495663 2015-02-26

Dose Escalation Study of I-131-CLR1404 in Subjects With Cancer That Does Not Respond to Treatment or Has Returned

BreastGastrointestinalGenitourinaryGynecologicSarcomaThoracic

12 enrolled

Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Recurrence, Sarcoma, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT00441337 2015-02-20

MDX1106-01

DermatologicGastrointestinalGenitourinaryThoracic

39 enrolled 28 charts

Adenocarcinoma, Carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Kidney Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Prostatic Neoplasms, Recurrence, Colorectal Neoplasms

NCT00276276 2013-04-15

Active Symptom Control Alone Or In Combination With Oral Topotecan In Patients With Relapsed Resistant Small Cell Lung Cancer

Phase 3 Completed

141 enrolled

Lung Neoplasms, Recurrence, Small Cell Lung Carcinoma

NCT00095199 2012-10-15

Docetaxel or Pemetrexed With or Without Cetuximab in Patients With Recurrent or Progressive Non-Small Cell Lung Cancer

Phase 3 Completed

939 enrolled 21 charts

EndocrineGynecologicOther solid neoplasmSarcomaThoracic

Carcinoma, Non-Small-Cell Lung, Recurrence

NCT01271959 2012-10-05

A Study of ChemoFx® Chemoresponse Assay in Solid Tumors - ChemoFx® Registry Study

Terminated

167 enrolled

Adenocarcinoma, Carcinoid Tumor, Mesothelioma, Recurrence, Sarcoma, Uterine Neoplasms

NCT00356122 2011-10-17

Docetaxel & Oxaliplatin in Combination With Bevacizumab as First-Line Treatment in Subjects With Non-Small Cell Lung Cancer (NSCLC)

53 enrolled 14 charts

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Neoplasms, Recurrence

NCT00120939 2009-04-03

Study of Motexafin Gadolinium and Docetaxel for Advanced Cancer

BreastCNSGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

25 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Glioblastoma, Head and Neck Neoplasms, Kidney Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Recurrence, Stomach Neoplasms, Urogenital Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT00116610 2009-01-21

Picoplatin as Second-Line Therapy for Patients With Small Cell Lung Cancer

75 enrolled