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Phase

Phase 1 1

Status

Recruiting 1

Sponsor Class

NIH 1

Study Type

Interventional 1

Sponsor

Cancer Type

Thoracic 1Other solid neoplasm 1Gynecologic 1Gastrointestinal 1

Conditions

Carcinoma, Non-Small-Cell Lung 60Lung Neoplasms 38Melanoma 22Ovarian Neoplasms 20Breast Neoplasms 18Mesothelioma, Malignant 13Colorectal Neoplasms 13Pancreatic Neoplasms 12Neoplasm Metastasis 12Small Cell Lung Carcinoma 11Triple Negative Breast Neoplasms 10Carcinoma, Renal Cell 10Neoplasms 9Mesothelioma 9Stomach Neoplasms 8Sarcoma 8Thymoma 7Carcinoma, Hepatocellular 7Squamous Cell Carcinoma of Head and Neck 6Carcinoma, Merkel Cell 6Esophageal Neoplasms 5Carcinoma, Transitional Cell 5Adenocarcinoma of Lung 5Uterine Cervical Neoplasms 4Urinary Bladder Neoplasms 4Sarcoma, Synovial 4Multiple Myeloma 4Head and Neck Neoplasms 4Colonic Neoplasms 4Carcinoma, Ovarian Epithelial 4

Interventions

pembrolizumab 3Quality of Life 2Proton Therapy 2Immunotherapy 2Drug Therapy 2fludarabine 1epacadostat 1bosutinib 1amrubicin 1alovudine 1Tumor Burden 1Sunitinib 1Radiotherapy 1Radiosurgery 1Radiation 1Plicamycin 1Pemetrexed 1Patient Reported Outcome Measures 1Molecular Diagnostic Techniques 1Histocompatibility Testing 1Erlotinib Hydrochloride 1Cyclophosphamide 1Blood Specimen Collection 1Biological Therapy 1Bevacizumab 1

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
Thymus Neoplasms × Cyclophosphamide × Thoracic × Clear all
NCT06885697 2026-06-05

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

National Institutes of Health Clinical Center (CC)

Phase 1 Recruiting
100 enrolled
GastrointestinalGynecologicOther solid neoplasmThoracic

Colonic Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Thymoma, Thymus Neoplasms

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