Announcements Trials
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Phase

Phase 2 2Phase 1/2 2Phase 3 1

Status

Completed 4Terminated 1

Sponsor Class

INDUSTRY 5

Study Type

Interventional 5

Sponsor

Cancer Type

Thoracic 5Breast 3Genitourinary 1Gastrointestinal 1

Conditions

Small Cell Lung Carcinoma 4Neoplasm Metastasis 1Lung Neoplasms 1Carcinoma, Non-Small-Cell Lung 1

Interventions

Carboplatin 335Pemetrexed 276Cisplatin 228Paclitaxel 193pembrolizumab 178Erlotinib Hydrochloride 173Docetaxel 154Gemcitabine 126Nivolumab 112Bevacizumab 112Radiotherapy 84Etoposide 68durvalumab 62atezolizumab 60Ipilimumab 51Radiosurgery 49osimertinib 42130-nm albumin-bound paclitaxel 40Afatinib 39Gefitinib 38Cetuximab 38Albumin-Bound Paclitaxel 37Taxes 32Vinorelbine 29Radiation 29Topotecan 28Drug Therapy 25Crizotinib 23Platinum 21Dexamethasone 21

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Has results × trilaciclib × Thoracic × Clear all
NCT02514447 2025-09-25

Trilaciclib (G1T28) in Patients With Previously Treated Extensive Stage SCLC Receiving Topotecan Chemotherapy

G1 Therapeutics, Inc.

Phase 1/2 Completed
123 enrolled 46 charts
Thoracic

Small Cell Lung Carcinoma

NCT03041311 2025-09-25

Carboplatin, Etoposide, and Atezolizumab With or Without Trilaciclib (G1T28), a CDK4/6 Inhibitor, in Extensive-Stage SCLC

G1 Therapeutics, Inc.

Phase 2 Completed
107 enrolled 42 charts
Thoracic

Small Cell Lung Carcinoma

NCT04902885 2024-07-10

Phase 3 Study Evaluating Efficacy, Safety and Pharmacokinetics of Trilaciclib In Small Cell Lung Cancer Patients

Jiangsu Simcere Pharmaceutical Co., Ltd.

Phase 3 Completed
95 enrolled 27 charts
Thoracic

Small Cell Lung Carcinoma

NCT04863248 2023-04-14

PRESERVE 4

G1 Therapeutics, Inc.

Phase 2 Terminated
10 enrolled 14 charts
Thoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT02499770 2020-08-21

Trilaciclib (G1T28), a CDK 4/6 Inhibitor, in Combination With Etoposide and Carboplatin in Extensive Stage Small Cell Lung Cancer (SCLC)

G1 Therapeutics, Inc.

Phase 1/2 Completed
122 enrolled 62 charts
Thoracic

Small Cell Lung Carcinoma

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