Clinical Trials

Phase 1 Active not recruiting

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Small Cell Lung Carcinoma

NCT02595931 2026-05-13

M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

66 enrolled

GastrointestinalThoracic

Lung Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Colorectal Neoplasms, Small Cell Lung Carcinoma

NCT05153239 2026-05-13

Clinical Trial of Lurbinectedin as Single-agent or in Combination With Irinotecan Versus Topotecan or Irinotecan in Patients With Relapsed Small-cell Lung Cancer (LAGOON)

Phase 3 Completed

705 enrolled

Phase 2 Not yet recruiting

Small Cell Lung Carcinoma

NCT07258147 2026-05-05

Safety and Efficacy of Radiotherapy Combined With Immunochemotherapy in Pre-treated SCLC Patients With Liver Metastases

30 enrolled

Phase 2 Active not recruiting

Lung Neoplasms

NCT06586515 2026-04-20

MOONRAY-01

Phase 1 Recruiting

630 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms

NCT03678883 2026-04-03

9-ING-41 in Patients With Advanced Cancers

350 enrolled

BreastCNSGastrointestinalGenitourinaryLymphoidOther hematologic neoplasmSarcomaThoracic

Bone Neoplasms, Breast Neoplasms, Glioma, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Neoplasm Metastasis, Neoplasms, Hereditary Sensory and Autonomic Neuropathies, Pancreatic Neoplasms, Sarcoma, Colorectal Neoplasms, Leukemia-Lymphoma, Adult T-Cell

NCT04640480 2026-01-27

Dose-finding Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of SNB-101(SN-38) in Patients With Tumors

BreastGastrointestinalGynecologicHead & NeckThoracic

21 enrolled

Breast Neoplasms, Head and Neck Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Small Cell Lung Carcinoma

NCT07155200 2025-12-22

Small Cell Lung Cancer Irinotecan and CDC2-like Kinase Inhibition Trial (SLICK Trial)

Phase 1/2 Recruiting

42 enrolled

CNSEndocrineGastrointestinalGynecologicNETOther solid neoplasmSarcomaThoracic

Small Cell Lung Carcinoma

NCT02611024 2025-07-09

Pharmacokinetic Study of Lurbinectedin in Combination With Irinotecan in Patients With Selected Solid Tumors

Phase 1/2 Completed

316 enrolled

Gastro-enteropancreatic neuroendocrine tumor, Carcinoma, Ovarian Epithelial, Glioblastoma, Mesothelioma, Neoplasms, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Neuroendocrine Tumors

NCT06954246 2025-06-18

A Study of MHB088C Injection Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer

Phase 3 Recruiting

450 enrolled

BreastDermatologicGenitourinaryGynecologicThoracic

Small Cell Lung Carcinoma

NCT02419495 2025-06-04

Phase IB Study to Evaluate the Safety of Selinexor (KPT-330) in Combination With Multiple Standard Chemotherapy or Immunotherapy Agents in Patients With Advanced Malignancies

Phase 1 Terminated

221 enrolled

Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Fallopian Tube Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Ovarian Neoplasms, Triple Negative Breast Neoplasms

NCT06963502 2025-05-09

A Phase Ib Study of HS-10370 in Addition to Other Anti-cancer Therapies in Patients With Advanced Solid Tumors

Phase 1 Not yet recruiting

762 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms

NCT02489903 2025-03-17

RRx-001 in Lung Cancer, Ovarian Cancer and Neuroendocrine Tumors Prior to Re-administration of Platinum Based Doublet Regimens (QUADRUPLE THREAT)

EndocrineGynecologicNETThoracic

139 enrolled 14 charts

Carcinoma, Ovarian Epithelial, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Carcinoma, Small Cell, Neuroendocrine Tumors

NCT06496048 2024-12-12

Lurbinectedin or in Combination with Irinotecan Versus Topotecan in Patients with Relapsed SCLC

Phase 3 Recruiting

180 enrolled

Small Cell Lung Carcinoma

NCT05049863 2024-12-05

Chemotherapy in Patients With Relapsed Small Cell Lung Cancer in Combination With Allopurinol and MycoPhenolate (CLAMP Trial)

Phase 1 Terminated

17 enrolled

Small Cell Lung Carcinoma

NCT03879798 2024-10-10

DS-3201b and Irinotecan for Patients With Recurrent Small Cell Lung Cancer

22 enrolled 9 charts

GastrointestinalGynecologicThoracic

Small Cell Lung Carcinoma

NCT01941316 2024-05-09

Study of Carfilzomib With Irinotecan in Irinotecan-Sensitive Malignancies and Small Cell Lung Cancer Patients

Phase 1/2 Completed

78 enrolled 15 charts

Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Ovarian Neoplasms, Stomach Neoplasms, Small Cell Lung Carcinoma

NCT05731518 2023-07-14

SC0245 and Irinotecan in Treating Patients With Relapsed Extensive-Stage Small Cell Lung Cancer (ES-SCLC)

Phase 1/2 Unknown

67 enrolled

Small Cell Lung Carcinoma

NCT00057837 2023-07-05

Comparison of Two Combination Chemotherapy Regimens in Treating Patients With Extensive-Stage Small Cell Lung Cancer

140 enrolled 8 charts

Extensive Stage Small Cell Lung Cancer

NCT05595889 2022-11-29

Surufatinib Combined With Irinotecan as a Second-line Treatment for Small Cell Lung Cancer

40 enrolled

Small Cell Lung Carcinoma

NCT04173325 2022-06-14

Feasibility and Safety Study of Nivolumab With Irinotecan for Small Cell Lung Cancer

Phase 1 Terminated

10 enrolled

Lung Neoplasms, Small Cell Lung Carcinoma

NCT01003964 2022-04-12

Pharmacogenomic Study for Providing Personalized Strategy to the Treatment of Non-small Cell Lung Cancer (NSCLC) IIIB/IV

289 enrolled

Carcinoma, Non-Small-Cell Lung

NCT00695292 2021-11-22

Irinotecan, Carboplatin, and Sunitinib in First Line Extensive-Stage Small Cell Lung Cancer

37 enrolled 10 charts

Small Cell Lung Carcinoma

NCT00025285 2021-09-09

Combination Chemotherapy Plus Thalidomide in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer

46 enrolled

Adenocarcinoma of Lung, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT04985201 2021-08-09

Combined Simvastatin and Irinotecan in Treating ES-SCLC Patients Relapsed From 1st Chemotherapy

40 enrolled

Small Cell Lung Carcinoma

NCT04543916 2021-03-03

Venetoclax and Irinotecan in Relapsed/Refractory SCLC

Phase 1/2 Withdrawn

Small Cell Lung Carcinoma

NCT04757779 2021-02-17

A Single-arm, Phase Ⅱ Clinical Trial of Anlotinib Hydrochloride Combined With Irinotecan or Docetaxel for Second Line Treatment of Nonsensitive Relapsed Small-cell Lung Cancer

40 enrolled

Small Cell Lung Carcinoma

NCT02171325 2021-02-03

Study of Different Doses of Irinotecan and Cisplatin for First-line Extensive-stage Small-cell Lung Cancer Treatment

54 enrolled

Small Cell Lung Carcinoma

NCT03098030 2020-12-09

Dinutuximab and Irinotecan Versus Irinotecan to Treat Subjects With Relapsed or Refractory Small Cell Lung Cancer

Phase 2/3 Completed

483 enrolled 19 charts

Small Cell Lung Carcinoma

NCT04453930 2020-07-01

A Study of Sequential Therapy of Camrelizumab Combined With Chemotherapy（Irinotecan Plus Platinum）and With Apatinib in Participants With Untreated Advanced Small Cell Lung Cancer（SCLC）

60 enrolled

Small Cell Lung Carcinoma

NCT01803282 2020-06-02

Study to Evaluate the Safety and Tolerability of Andecaliximab as Monotherapy and in Combination With Chemotherapy in Participants With Advanced Solid Tumors

BreastGastrointestinalThoracic

236 enrolled 21 charts

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Pancreatic Neoplasms, Colorectal Neoplasms

NCT03613753 2020-02-05

Irinotecan Plus Lobaplatin Versus Irinotecan in the Second-line Treatment of Small Cell Lung Cancer

72 enrolled

Recurrence, Small Cell Lung Carcinoma

NCT02275806 2019-08-21

Cisplatin/Irinotecan With Concurrent Radiation for Inoperable NSCLC

Phase 2 Terminated

4 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00465907 2019-02-11

Study of Weekly Paclitaxel, Carboplatin and Irinotecan to Treat Lung Cancer

Phase 2 Terminated

7 enrolled

Lung Neoplasms

NCT03651219 2018-08-29

Mesylate Apatinib Combined With Irinotecan in Treatment of Recurrent Small Cell Lung Cancer

Phase 3 Unknown

90 enrolled

Small Cell Lung Carcinoma

NCT00045162 2018-07-31

S0124: Cisplatin Combined With Irinotecan or Etoposide For Extensive-Stage Small Cell Lung Cancer

Phase 3 Completed

671 enrolled 10 charts

Lung Neoplasms

NCT01935947 2018-07-27

Azacitidine and Entinostat Before Chemotherapy in Treating Patients With Advanced Non-small Cell Lung Cancer

Phase 2 Terminated

17 enrolled 10 charts

Carcinoma, Non-Small-Cell Lung

NCT02331251 2018-07-02

Study of Pembrolizumab Plus Chemotherapy in Patients With Advanced Cancer (PembroPlus)

BreastGastrointestinalSarcomaThoracic

81 enrolled

Breast Neoplasms, Pancreatic Neoplasms, Sarcoma, Small Cell Lung Carcinoma

NCT02423954 2018-07-02

NivoPlus

GastrointestinalGenitourinaryThoracic

33 enrolled

Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Pancreatic Neoplasms, Colorectal Neoplasms

NCT01607554 2018-05-22

Irinotecan for Previously Treated, Advanced, Non-Small Cell Lung Cancer

2 enrolled 6 charts

Carcinoma, Non-Small-Cell Lung

NCT01520389 2018-03-21

Safety Study of the Drug MM-151 in Patients With Advanced Solid Tumors Resisting Ordinary Treatment

BreastGastrointestinalHead & NeckThoracic

112 enrolled

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Neoplasms, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT00387660 2018-01-10

Irinotecan and Carboplatin in Treating Patients With Metastatic or Recurrent Small Cell Lung Cancer

80 enrolled 8 charts

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00856830 2017-07-17

Bendamustine With Irinotecan Followed by Etoposide/Carboplatin for Patients With Extensive Stage Small Cell Lung Cancer

Phase 1/2 Completed

30 enrolled 12 charts

Small Cell Lung Carcinoma

NCT00004095 2017-04-18

Irinotecan Plus Gemcitabine in Treating Patients With Unresectable or Metastatic Solid Tumors