Clinical Trials Browser

Interventional × Metformin × Thoracic × Clear all

NCT02186847 2026-05-22

Chemotherapy and Radiation Therapy With or Without Metformin Hydrochloride in Treating Patients With Stage III Non-small Cell Lung Cancer

Phase 2 Completed

170 enrolled 19 charts

Adenocarcinoma of Lung, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung

NCT05445791 2026-04-09

METLUNG

Phase 3 Recruiting

Carcinoma, Non-Small-Cell Lung

NCT02122185 2026-03-27

Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Phase 2 Completed

111 enrolled 15 charts

GynecologicThoracic

Carcinoma, Ovarian Epithelial, Brenner Tumor, Fallopian Tube Neoplasms, Pleural Effusion, Malignant

NCT04931017 2025-10-07

Metformin for Chemoprevention of Lung Cancer in Overweight or Obese Individuals at High Risk for Lung Cancer

Phase 2 Active not recruiting

Lung Neoplasms

NCT02431676 2024-08-28

SPIRIT

Phase 2 Completed

121 enrolled 12 charts

BreastDermatologicGastrointestinalGenitourinaryGynecologicThoracic

Breast Neoplasms, Colonic Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Endometrial Neoplasms

NCT03477162 2023-10-03

Metformin Pharmacology in Human Cancers: A Proof of Principle Study

Phase EARLY_PHASE1 Terminated

18 enrolled 10 charts

Thoracic Neoplasms

NCT04170959 2021-01-15

RADFORMIN

Phase 2 Terminated

Carcinoma, Non-Small-Cell Lung

NCT03048500 2020-10-14

Nivolumab and Metformin Hydrochloride in Treating Patients With Stage III-IV Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

Phase 2 Unknown

17 enrolled 10 charts

Carcinoma, Non-Small-Cell Lung

NCT03086733 2020-08-19

Metcore

Phase 2 Completed

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasms

NCT02115464 2020-04-22

ALMERA

Phase 2 Terminated

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT01717482 2020-03-10

Metformin as a Chemoprevention Agent in Non-small Cell Lung Cancer

Phase 2 Terminated

6 enrolled 5 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02285855 2020-01-06

Metformin in Non Small Cell Lung Cancer (NSCLC)

Phase 2 Terminated

27 enrolled 11 charts

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT04001725 2019-11-13

OPTIMAL

Phase 2 Unknown

BreastCNSDermatologicThoracic

Brain Neoplasms, Breast Neoplasms, Diabetes Mellitus, Lung Neoplasms, Melanoma, Neoplasms

NCT03994744 2019-08-28

Assessing Safety and Efficacy of Sintilimab and Metformin Combination Therapy in SCLC

Phase 2 Unknown

Small Cell Lung Carcinoma

NCT03874000 2019-03-19

SMART

Phase 2 Unknown

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT01578551 2018-12-19

Study of Metformin Plus Paclitaxel/Carboplatin/Bevacizumab in Patients With Adenocarcinoma.

Phase 2 Terminated

25 enrolled 9 charts

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung

NCT01864681 2018-06-20

CGMT

Phase 2 Completed

Carcinoma, Non-Small-Cell Lung

NCT02019979 2018-05-04

METRO

Phase 2 Terminated

14 enrolled 7 charts

Lung Neoplasms

NCT01997775 2016-09-30

Metformin in Stage IV Lung Adenocarcinoma

Phase 2 Terminated

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung

NCT00659568 2013-05-30

Metformin and Temsirolimus in Treating Patients With Metastatic or Unresectable Solid Tumor or Lymphoma

Phase 1 Completed

BreastDermatologicGenitourinaryGynecologicLymphoidOther hematologic neoplasmThoracic

Breast Neoplasms, Burkitt Lymphoma, Carcinoma, Renal Cell, Hodgkin Disease, Immunoblastic Lymphadenopathy, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Mycosis Fungoides, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Endometrial Neoplasms, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Small Cell Lung Carcinoma