Clinical Trials

Neoplasms

NCT05694715 2026-03-17

Combination Therapy in Cancers With Mutations in DNA Repair Genes

Phase 1 Recruiting

24 enrolled

Neoplasm Metastasis

NCT05004116 2026-03-04

A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer

Phase 1/2 Recruiting

77 enrolled

Neoplasm Metastasis

NCT05365581 2026-02-13

A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer

Phase 1 Recruiting

398 enrolled

Adenocarcinoma

NCT02813135 2026-01-16

ESMART

Phase 1/2 Recruiting

472 enrolled

Phase 2 Active not recruiting

Neoplasms

NCT06107413 2025-12-12

Study to Assess Adverse Events and Change in Disease Activity in Previously Treated Adult Participants Receiving Intravenous (IV) ABBV-400 With Unresectable Metastatic Colorectal Cancer in Combination With IV Fluorouracil, Folinic Acid, and Bevacizumab

280 enrolled

Neoplasms

NCT04361708 2025-10-01

I-FLOAT

Phase 1 Recruiting

54 enrolled

Phase 2 Active not recruiting

Adenocarcinoma

NCT03806309 2025-07-25

TEDOPAM

106 enrolled

Phase 3 Active not recruiting

Neoplasm Metastasis

NCT04879368 2025-07-17

INTEGRATEIIb

450 enrolled

Adenocarcinoma, Carcinoma, Neoplasm Metastasis

NCT05217069 2025-04-16

FOLFIRI + Cetuximab + Avelumab RAS Wild-type CRC

57 enrolled

Neoplasms, Second Primary

NCT03722108 2023-10-16

REGIRI

Phase 1/2 Terminated

89 enrolled

Adenocarcinoma

NCT00060567 2023-06-18

Dose-Finding Study of E7070 in Combination With Irinotecan

88 enrolled

Neoplasms

NCT03665441 2022-10-18

Trybeca-1

Phase 3 Completed

512 enrolled 19 charts

Neoplasms

NCT02049593 2022-09-26

PARP Inhibitor BMN-673 and Temozolomide or Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic Solid Tumors

44 enrolled

Neoplasm Metastasis

NCT02801097 2022-05-17

PAYLOAD

28 enrolled

Neoplasm Metastasis

NCT02178709 2022-04-19

A Phase II Study of Neoadjuvant FOLFIRINOX

48 enrolled 16 charts

Neoplasms

NCT01660711 2021-11-08

A Pilot Study of Pre- and Post-surgery Chemotherapy With mFOLFIRINOX in Localized, Resectable Pancreatic Adenocarcinoma

22 enrolled 8 charts

Adenocarcinoma, Neoplasms

NCT03096340 2020-12-22

Safety and Pharmacokinetic Study of IT-141 in Monotherapy in Patients With Advanced Cancer

10 enrolled

Neoplasms

NCT01896856 2020-10-06

Phase I/II Study of SGI-110 With Irinotecan Versus Regorafenib or TAS-102 in Metastatic Colorectal Cancer

Phase 1/2 Completed

118 enrolled 16 charts

Neoplasm Metastasis

NCT02677116 2020-05-20

A Study of Olaratumab Alone and in Combination With Standard Chemotherapies in Children With Cancer

68 enrolled 26 charts

Neoplasm Metastasis

NCT00062842 2020-03-04

Study of Irinotecan on a Weekly Schedule in Children

23 enrolled

Neoplasms

NCT01653470 2020-01-28

Study to Evaluate Safety & Tolerability of BMS-906024 in Combination With Chemotherapy & to Define DLTs & MTD of BMS-906024 in Combination With One of the Following Chemotherapy Regimens; Weekly Paclitaxel, 5FU+Irinotecan or Carboplatin+Paclitaxel in Subjects With Advanced / Metastatic Solid Tumors

141 enrolled

Neoplasms

NCT01274624 2018-12-19

Study of REOLYSIN® in Combination With FOLFIRI and Bevacizumab in FOLFIRI Naive Patients With KRAS Mutant Metastatic Colorectal Cancer

36 enrolled

Neoplasms

NCT02620423 2018-09-13

Study of Pembrolizumab With REOLYSIN® and Chemotherapy in Patients With Advanced Pancreatic Adenocarcinoma

11 enrolled

Neoplasms

NCT00954512 2018-08-24

Study of Robatumumab (SCH 717454, MK-7454) in Combination With Different Treatment Regimens in Participants With Advanced Solid Tumors (P04722, MK-7454-004)

Phase 1/2 Terminated

15 enrolled 11 charts

Neoplasms

NCT02241551 2018-07-26

Phase II Neoadjuvant Chemotheraphy (Gemcitabine and Nab-Paclitaxel vs. mFOLFIRINOX) and Sterotatic Body Radiation Therapy for Borderline Resectable Pancreatic Cancer

Phase 2 Terminated

2 enrolled 7 charts

Neoplasms

NCT02316496 2017-08-01

REGAIN

Phase 2 Terminated

2 enrolled

Neoplasm Metastasis, Neoplasms

NCT00066781 2017-04-04

Gemcitabine and Irinotecan in Treating Patients With Cancer of Unknown Primary

31 enrolled 8 charts

Neoplasms, Unknown Primary

NCT02640365 2017-01-31

DOUBLIRI

10 enrolled

Neoplasms

NCT00811993 2016-11-02

A Study of R1507 in Combination With Multiple Standard Chemotherapy Treatments in Patients With Advanced Solid Tumors

104 enrolled

Neoplasms

NCT00507091 2016-08-25

Phase I Irinotecan, 5-Fluorouracil and Leucovorin Combination

24 enrolled

Adenocarcinoma, Neoplasm Metastasis

NCT00110357 2015-12-24

Study of Erbitux™ (Cetuximab) in Pediatric Patients With Refractory Solid Tumors

48 enrolled 22 charts

Neoplasms

NCT01930552 2015-01-07

A Phase I Study of Aflibercept Plus FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin) in Chinese Patients With Advanced Solid Malignancies

20 enrolled

Neoplasms

NCT00193596 2013-05-03

Gemcitabine/Irinotecan/ZD1839 vs Paclitaxel/Carboplatin/Etoposide/ZD1839 in Carcinoma of Unknown Primary Site

Phase 3 Completed

198 enrolled 7 charts

Neoplasms, Unknown Primary

NCT00298675 2012-08-02

Phase 1/1b Dose Escalation Study Evaluating BSI-201 as a Single Agent and in Combination With Irinotecan in Subjects With Advanced Solid Tumors

59 enrolled

Neoplasms

NCT00057473 2011-04-14

A Phase II Study of Carboplatin Plus Irinotecan Versus Irinotecan in Children With Refractory Solid Tumors

Neoplasms

NCT00473616 2011-02-11

Phase I Single Ascending Dose/Multiple Ascending Dose in Patients Treated With AZD7762 and Irinotecan

60 enrolled

Neoplasms

NCT00249977 2010-01-07

Phase I Study of Capecitabine in Combination With Cisplatin and Irinotecan

21 enrolled

Neoplasms

NCT00001495 2008-03-04

A Phase I Study of Irinotecan (CPT-11) Administered as a Prolonged Infusion in Adult Patients With Solid Tumors

40 enrolled