Clinical Trials Browser

Interventional × ACTH Syndrome, Ectopic × Clear all

Adrenal incidentaloma, ACTH Syndrome, Ectopic, Cushing Syndrome, Insulin Resistance, Weight Loss

NCT07296484 2026-03-19

CAPTAIN-T2D

Phase 2 Recruiting

1,500 enrolled

ACTH Syndrome, Ectopic, Cushing Syndrome, Diabetes Mellitus, Type 2

NCT07247058 2026-03-05

Isturisa Treatment in Mild Autonomous Cortisol Secretion( MACS)

Phase 4 Recruiting

10 enrolled

ACTH Syndrome, Ectopic, Adrenal Hyperplasia, Congenital, Hypertension

NCT03604198 2026-02-19

Extension Study to Evaluate the Safety of Long-Term Use of Relacorilant in Patients With Cushing Syndrome

Phase 2 Active not recruiting

125 enrolled

Endocrine

ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Cushing Syndrome, Diabetes Mellitus, Type 2, Hypertension, Adrenocortical Carcinoma, Pituitary ACTH Hypersecretion

NCT07104812 2026-02-11

Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS)

Phase 2 Recruiting

15 enrolled

ACTH Syndrome, Ectopic, Adrenal Hyperplasia, Congenital, Cushing Syndrome

NCT07247162 2025-12-10

LINC CARE

Phase 4 Not yet recruiting

63 enrolled

ACTH Syndrome, Ectopic, Cushing Syndrome, Hypertension

NCT05307328 2025-10-08

RESCUE

Phase 2 Completed

26 enrolled

Endocrine

ACTH Syndrome, Ectopic, Cushing Syndrome, Pituitary ACTH Hypersecretion

NCT06106295 2025-09-22

Metyrapone for Mild Autonomous Cortisol Secretion (MACS)

Phase 2 Active not recruiting

30 enrolled

ACTH Syndrome, Ectopic, Adrenal Hyperplasia, Congenital, Cushing Syndrome

NCT04308590 2025-09-04

GRADIENT

Phase 3 Completed

137 enrolled 25 charts

ACTH Syndrome, Ectopic, Cushing Syndrome, Diabetes Mellitus, Type 2, Hypertension

NCT07138274 2025-08-22

Metyrapone Study for Patients Diagnosed With Mild Autonomous Cortisol Secretion - MACS

Phase 2 Not yet recruiting

90 enrolled

ACTH Syndrome, Ectopic, Adrenal Hyperplasia, Congenital, Cushing Syndrome

NCT03697109 2025-07-16

GRACE

Phase 3 Completed

152 enrolled 28 charts

Endocrine

ACTH Syndrome, Ectopic, Cushing Syndrome, Diabetes Mellitus, Type 2, Hypertension, Pituitary ACTH Hypersecretion

NCT05804669 2025-04-10

A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome

Phase 1/2 Recruiting

18 enrolled

Endocrine

ACTH Syndrome, Ectopic, Cushing Syndrome, Pituitary ACTH Hypersecretion

NCT05315388 2024-09-27

Effects of "Vitamin N" Nature Immersion Therapy on Stress Levels in Health Care Workers in the City of Bogotá

Phase NA Active not recruiting

118 enrolled

ACTH Syndrome, Ectopic, Anxiety Disorders, Stress, Psychological

NCT06576336 2024-08-28

3DAdrenal

Phase 4 Completed

350 enrolled

Endocrine

ACTH Syndrome, Ectopic, Adrenal Gland Neoplasms

NCT04373265 2024-02-23

Study of Relacorilant in Combination With Pembrolizumab for Patients With Adrenocortical Carcinoma Which Produces Too Much Stress Hormone (Cortisol)

Phase 1 Completed

15 enrolled

Endocrine

ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Adrenal Gland Diseases, Adrenocortical Hyperfunction, Cushing Syndrome, Diabetes Mellitus, Type 2, Endocrine System Diseases, Hyperglycemia, Hypertension, Pathologic Processes, Glucose Intolerance, Adrenocortical Carcinoma

NCT05839483 2023-07-17

CXCR4 Targeted PET Imaging in APA Preoperative Localization Diagnosis

Phase NA Unknown

50 enrolled

Endocrine

ACTH Syndrome, Ectopic, Hypertension, Hypokalemia, Adrenocortical Adenoma

NCT05523115 2022-11-08

An Exploratory Investigation of a Supplement to Promote Cognitive Health Benefits

Phase NA Completed

34 enrolled

ACTH Syndrome, Ectopic, Anxiety Disorders, Memory Disorders

NCT05607706 2022-11-07

Effect of Maternal Odor and Kangaroo Care on Serum Cortisol and Comfort Levels in Preterm Infants: a Randomised Trial

Phase NA Completed

92 enrolled

ACTH Syndrome, Ectopic, Premature Birth

NCT05361083 2022-05-04

First-in-human Evaluation of [18F]CETO

Phase EARLY_PHASE1 Completed

20 enrolled

Endocrine

ACTH Syndrome, Ectopic, Adrenocortical Carcinoma

NCT02468193 2020-05-06

Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome

Phase 2 Completed

9 enrolled 22 charts

Acth-Independent Macronodular Adrenal Hyperplasia, ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Cushing Syndrome

NCT02804750 2019-10-15

Study to Evaluate CORT125134 in Participants With Cushing's Syndrome

Phase 2 Completed

35 enrolled 13 charts

Endocrine

ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Cushing Syndrome, Diabetes Mellitus, Type 2, Hypertension, Adrenocortical Carcinoma, Pituitary ACTH Hypersecretion

NCT00422201 2019-10-11

Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion

Phase 2 Terminated

18 enrolled 9 charts

ACTH Syndrome, Ectopic, Cushing Syndrome

NCT02756754 2019-07-16

ADERADHTA

Phase NA Completed

31 enrolled

ACTH Syndrome, Ectopic, Hyperaldosteronism

NCT02780882 2018-01-26

SOM230 Ectopic ACTH-producing Tumors

Phase 2 Withdrawn

ACTH Syndrome, Ectopic

NCT00958841 2016-07-26

Study of Pasireotide in Patients With Rare Tumors of Neuroendocrine Origin

Phase 2 Terminated

118 enrolled 11 charts

EndocrineGastrointestinal

ACTH Syndrome, Ectopic, Nelson Syndrome, Pancreatic Neoplasms, Pituitary Neoplasms, Neuroectodermal Tumors, Primitive

NCT02127840 2014-05-01

ISIRA

Phase 4 Unknown

40 enrolled

ACTH Syndrome, Ectopic, Hyperaldosteronism, Hypertension

NCT00936741 2014-04-02

An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome

Phase 3 Completed

30 enrolled 8 charts

Endocrine

ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Choristoma, Cushing Syndrome, Hirsutism, Pituitary Diseases, Pituitary ACTH Hypersecretion

NCT01371565 2014-03-18

Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's Syndrome

Phase 3 Completed

4 enrolled 7 charts

Endocrine

ACTH Syndrome, Ectopic, Cushing Syndrome, Pituitary Diseases, Pituitary ACTH Hypersecretion

NCT00569582 2013-08-22

SEISMIC

Phase 3 Completed

50 enrolled 8 charts

Endocrine

ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Choristoma, Cushing Syndrome, Hirsutism, Pituitary Diseases, Pituitary ACTH Hypersecretion

Clinical Trials

IMPACT-MACS

CAPTAIN-T2D

Isturisa Treatment in Mild Autonomous Cortisol Secretion( MACS)

Extension Study to Evaluate the Safety of Long-Term Use of Relacorilant in Patients With Cushing Syndrome

Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS)

LINC CARE

RESCUE

Metyrapone for Mild Autonomous Cortisol Secretion (MACS)

GRADIENT

Metyrapone Study for Patients Diagnosed With Mild Autonomous Cortisol Secretion - MACS

GRACE

A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome

Effects of "Vitamin N" Nature Immersion Therapy on Stress Levels in Health Care Workers in the City of Bogotá

3DAdrenal

Study of Relacorilant in Combination With Pembrolizumab for Patients With Adrenocortical Carcinoma Which Produces Too Much Stress Hormone (Cortisol)

CXCR4 Targeted PET Imaging in APA Preoperative Localization Diagnosis

An Exploratory Investigation of a Supplement to Promote Cognitive Health Benefits

Effect of Maternal Odor and Kangaroo Care on Serum Cortisol and Comfort Levels in Preterm Infants: a Randomised Trial

First-in-human Evaluation of [18F]CETO

Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome

Study to Evaluate CORT125134 in Participants With Cushing's Syndrome

Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion

ADERADHTA

SOM230 Ectopic ACTH-producing Tumors

Study of Pasireotide in Patients With Rare Tumors of Neuroendocrine Origin

ISIRA

An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome

Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's Syndrome

SEISMIC