Clinical Trials

180 enrolled

Adenocarcinoma Of Esophagus, Neoplasm Metastasis, Stomach Neoplasms

NCT04939051 2026-05-13

Obeticholic Acid for Prevention in Barrett's Esophagus

30 enrolled

Adenocarcinoma Of Esophagus, Barrett Esophagus

NCT04389632 2026-05-11

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

GastrointestinalGenitourinaryGynecologicHead & NeckThoracic

1,006 enrolled

Adenocarcinoma Of Esophagus, Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Ovarian Neoplasms, Stomach Neoplasms

NCT05677490 2026-05-08

mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

Phase 3 Recruiting

382 enrolled

Adenocarcinoma Of Esophagus

NCT05954312 2026-05-08

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130037 in Participants With Advanced Solid Tumors

290 enrolled

Adenocarcinoma Of Esophagus, Neoplasms

NCT07021066 2026-04-30

Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of BL-M05D1 in Subjects With Solid Tumors

160 enrolled

Adenocarcinoma Of Esophagus, Biliary Tract Neoplasms

NCT06846346 2026-04-28

GRACIE

88 enrolled

Adenocarcinoma Of Esophagus, Adenocarcinoma, Neoplasm Metastasis, Neoplasms

NCT04114136 2026-04-24

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

DermatologicGastrointestinalHead & Neck

72 enrolled

Adenocarcinoma Of Esophagus, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hepatocellular, Melanoma

NCT07223424 2026-04-16

PSI-Immune

DermatologicGastrointestinalGenitourinaryGynecologicThoracic

880 enrolled

Adenocarcinoma Of Esophagus, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms, Colitis, Ulcerative, Colonic Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma

NCT03161522 2026-04-15

Chemotherapy With or Without Radiation or Surgery in Treating Participants With Oligometastatic Esophageal or Gastric Cancer

100 enrolled

Adenocarcinoma Of Esophagus, Esophageal Neoplasms, Stomach Neoplasms

NCT05745857 2026-04-13

SLURP

25 enrolled

Adenocarcinoma Of Esophagus, Barrett Esophagus

NCT07392892 2026-04-13

A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer

Phase 2/3 Recruiting

840 enrolled

Adenocarcinoma Of Esophagus, Stomach Neoplasms

NCT07090499 2026-04-07

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

GastrointestinalGenitourinaryHead & NeckThoracic

310 enrolled

Adenocarcinoma Of Esophagus, Adenocarcinoma of Lung, Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Transitional Cell, Esophageal Neoplasms, Head and Neck Neoplasms, Pancreatic Neoplasms

NCT06657144 2026-04-06

A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors

154 enrolled

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Neoplasm Metastasis, Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT07277413 2026-04-03

A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

GastrointestinalGenitourinaryOther solid neoplasmThoracic

260 enrolled

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Mesothelioma, Malignant, Urinary Bladder Neoplasms, Carcinoma, Transitional Cell, Mesothelioma, Neoplasm Metastasis, Recurrence

NCT04900818 2026-03-05

Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

330 enrolled

Adenocarcinoma Of Esophagus, Biliary Tract Neoplasms, Neoplasm Metastasis, Stomach Neoplasms

NCT07282912 2026-03-04

OLIGOMETS

54 enrolled

Adenocarcinoma Of Esophagus, Cholangiocarcinoma

NCT06005493 2026-02-24

Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors

Phase 1/2 Recruiting

280 enrolled

Adenocarcinoma Of Esophagus, Stomach Neoplasms

NCT06523374 2026-02-24

Endeavor-1

50 enrolled

DermatologicGastrointestinalGynecologicHead & NeckThoracic

Adenocarcinoma Of Esophagus, Barrett Esophagus, Esophageal Neoplasms

NCT07023731 2026-02-19

A Study to Evaluate ARV-806 in Adults With Advanced Cancer That Has the KRAS G12D Mutation

Phase 1/2 Recruiting

159 enrolled

Adenocarcinoma Of Esophagus, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Gallbladder Neoplasms, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma

NCT06330064 2026-02-12

A Study To Evaluate The Efficacy And Safety Of Ifinatamab Deruxtecan (I-DXd) In Subjects With Recurrent Or Metastatic Solid Tumors (IDeate-PanTumor02)

DermatologicGastrointestinalGenitourinaryGynecologicHead & Neck

520 enrolled

Adenocarcinoma Of Esophagus, Squamous Cell Carcinoma of Head and Neck, Biliary Tract Neoplasms, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Melanoma, Ovarian Neoplasms, Recurrence, Colorectal Neoplasms, Endometrial Neoplasms

NCT07182149 2026-02-12

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

BreastGastrointestinalGynecologicHead & Neck

150 enrolled

Adenocarcinoma Of Esophagus, Squamous Cell Carcinoma of Head and Neck, Uterine Cervical Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT06623396 2026-02-11

A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer

BreastGastrointestinalGynecologic

18 enrolled

Adenocarcinoma Of Esophagus, Breast Neoplasms, Diabetes Mellitus, Peritoneal Neoplasms

NCT07375420 2026-02-02

OPTIMUS

50 enrolled

Adenocarcinoma Of Esophagus, Esophageal Neoplasms, Motor Activity

NCT04290806 2026-01-28

SAPHIR

Recruiting

1,900 enrolled

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Neoplasms

NCT06266299 2026-01-28

A Study of KK2269 in Adult Participants With Solid Tumors

101 enrolled

GastrointestinalThoracic

Adenocarcinoma Of Esophagus, Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT03961945 2026-01-26

Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

1,550 enrolled

Adenocarcinoma Of Esophagus, Barrett Esophagus, Esophageal Neoplasms, Gastroesophageal Reflux

NCT03539822 2026-01-21

CAMILLA

Phase 1/2 Recruiting

117 enrolled

Adenocarcinoma Of Esophagus, Carcinoma, Hepatocellular, Stomach Neoplasms, Colorectal Neoplasms

NCT06161818 2025-12-22

TNT-OES-2

216 enrolled

Adenocarcinoma Of Esophagus, Esophageal Neoplasms

NCT07059299 2025-12-19

NeoTISLEGA

18 enrolled

Adenocarcinoma Of Esophagus, Stomach Neoplasms

NCT06532734 2025-12-10

Barrett's Esophagitis in Anorexia Nervosa Binge/Purge Subtype

Recruiting

25 enrolled

Adenocarcinoma Of Esophagus, Rumination Syndrome, Anorexia Nervosa, Feeding and Eating Disorders, Barrett Esophagus, Bulimia, Vomiting

NCT05753748 2025-11-24

SURVENT

680 enrolled

Adenocarcinoma Of Esophagus, Barrett Esophagus

NCT06687603 2025-11-13

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

800 enrolled

Adenocarcinoma Of Esophagus, Barrett Esophagus, Gastroesophageal Reflux

NCT05563766 2025-11-05

A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer

78 enrolled

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma

NCT04221893 2025-10-06

Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers

28 enrolled

Adenocarcinoma Of Esophagus, Anal Canal Carcinoma, Esophageal Squamous Cell Carcinoma, Anus Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Carcinoma, Hepatocellular, Stomach Neoplasms, Colorectal Neoplasms

NCT06687876 2025-07-10

MEMENTO

14 enrolled