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Phase

Phase 2 1

Status

Recruiting 1

Sponsor Class

OTHER 1

Study Type

Interventional 1

Sponsor

Cancer Type

Gastrointestinal 1

Conditions

Pancreatic Neoplasms 4Ovarian Neoplasms 3Lung Neoplasms 3Uterine Cervical Neoplasms 2Thyroid Neoplasms 2Stomach Neoplasms 2Mesothelioma, Malignant 2Carcinoma, Non-Small-Cell Lung 2Uveal Melanoma 1Uterine Neoplasms 1Urinary Bladder Neoplasms 1Rectal Neoplasms 1Prostatic Neoplasms 1Neoplasms, Mesothelial 1Multiple Myeloma 1Mesothelioma 1Mesonephric Gynecologic Cancer 1Melanoma 1Lymphoma 1Low-Grade Serous Ovarian Cancer 1Hematologic Neoplasms 1Glioma 1Esophageal Neoplasms 1Endometrial Neoplasms 1Colorectal Neoplasms 1Colonic Neoplasms 1Carcinoma, Renal Cell 1Carcinoma, Hepatocellular 1Breast Neoplasms 1Advanced Colorectal Cancer 1

Interventions

Oxaliplatin 3Cetuximab 3Capecitabine 3Irinotecan 2trifluridine tipiracil drug combination 1surufatinib 1regorafenib 1raltitrexed 1plocabulin 1nimotuzumab 1irinotecan sucrosofate 1endostar protein 1durvalumab 1defactinib 1Panitumumab 1N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide 1Drug Therapy 1Bevacizumab 1

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
Phase 2 × Advanced Colorectal Cancer × defactinib × Clear all
NCT06369259 2026-05-20

Open-label Phase 2 Study of Avutometinib (RAF/MEK Clamp) in Combination With Defactinib (FAK Inhibitor) and Cetuximab in Patients With Unresectable, Anti-EGFR-Refractory Advanced Colorectal Cancer

M.D. Anderson Cancer Center

Phase 2 Recruiting
33 enrolled
Gastrointestinal

Advanced Colorectal Cancer

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