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Phase

Phase 2 1

Status

Terminated 1

Sponsor Class

NIH 1

Study Type

Interventional 1

Sponsor

Cancer Type

Breast 1

Conditions

Melanoma 47Carcinoma, Non-Small-Cell Lung 16Colorectal Neoplasms 14Lung Neoplasms 11Neoplasm Metastasis 10Pancreatic Neoplasms 9Brain Neoplasms 9Neoplasms 8Triple Negative Breast Neoplasms 6Skin Neoplasms 5Colonic Neoplasms 5Rectal Neoplasms 4Ovarian Neoplasms 4Uveal Melanoma 3Thyroid Neoplasms 3Multiple Myeloma 3Hematologic Neoplasms 3Glioma 3Gastrointestinal Stromal Tumors 3Breast Neoplasms 3Biliary Tract Neoplasms 3Solid Tumor 2Skin Diseases 2Recurrence 2Neurofibromatosis 1 2Lymphoma 2Leukemia, Hairy Cell 2Hereditary Sensory and Autonomic Neuropathies 2Fallopian Tube Neoplasms 2Endometrial Neoplasms 2

Interventions

Magnetic Resonance Spectroscopy 5Specimen Handling 4Biopsy 3Steroids 2Hormones 2Cyclin-Dependent Kinase Inhibitor p18 2Cyclin-Dependent Kinase Inhibitor p16 2trastuzumab deruxtecan 1trastuzumab biosimilar HLX02 1taxane 1radium Ra 223 dichloride 1pertuzumab 1pembrolizumab 1naxitamab 1eicosapentaenoic acid ethyl ester 1eicosapentaenoic acid ethanolamide 1binimetinib 1abemaciclib 1X-Rays 1Vorinostat 1Trastuzumab 1Taxoids 1Taxes 1Tamoxifen 1Radiotherapy 1Radiosurgery 1Radiation 1Photons 1Paclitaxel 1PF-05280014 1

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
Anatomic Stage IV Breast Cancer AJCC v8 × binimetinib × Clear all
NCT05554354 2026-03-03

Testing the Use of Fulvestrant and Binimetinib Targeted Treatment for NF1 Mutation in Hormone Receptor-Positive Metastatic Breast Cancer (A ComboMATCH Treatment Trial)

National Cancer Institute (NCI)

Phase 2 Terminated
1 enrolled
Breast

Anatomic Stage IV Breast Cancer AJCC v8

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