Clinical Trials

24 enrolled

Anus Neoplasms

NCT04432597 2026-05-18

HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers

GastrointestinalGynecologicHead & Neck

39 enrolled

Anus Neoplasms, Uterine Cervical Neoplasms, Oropharyngeal Neoplasms, Rectal Neoplasms

NCT01408407 2026-05-14

Alkagin Paste in the Prevention of Radiation Dermatitis

Phase 2 Terminated

2 enrolled

Phase 3 Active not recruiting

Anus Neoplasms, Rectal Neoplasms, Urogenital Neoplasms

NCT03233711 2026-05-13

Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

344 enrolled

Phase 2 Active not recruiting

Anal Canal Carcinoma, Anus Neoplasms

NCT04929028 2026-05-13

Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer

40 enrolled

Phase 2 Active not recruiting

Anus Neoplasms, Rectal Neoplasms, HIV Infections

NCT02314169 2026-05-12

Nivolumab With or Without Ipilimumab in Treating Patients With Refractory Metastatic Anal Canal Cancer

143 enrolled 16 charts

Anal Canal Carcinoma, Anus Neoplasms

NCT07192055 2026-05-12

SOLO

Phase NA Recruiting

572 enrolled

Phase 2 Active not recruiting

Anus Neoplasms

NCT04166318 2026-05-05

Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study

252 enrolled

Phase 3 Active not recruiting

Anal Canal Carcinoma, Anus Neoplasms

NCT04444921 2026-05-04

EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients

205 enrolled

GastrointestinalGynecologic

Anal Canal Carcinoma, Anus Neoplasms

NCT07029152 2026-05-01

SCOPE

Phase NA Recruiting

296 enrolled

Squamous Intraepithelial Lesions, Anus Neoplasms, Carcinoma, Squamous Cell, Homosexuality

NCT07555678 2026-04-29

Chase

241 enrolled

Anus Neoplasms

NCT07407647 2026-04-21

Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer

GastrointestinalGynecologic

25 enrolled

Anus Neoplasms, Uterine Cervical Neoplasms, Rectal Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT02437851 2026-04-20

Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection

Phase 2 Completed

16 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicThoracic

Anal Canal Carcinoma, Anus Neoplasms, HIV Infections

NCT06270706 2026-04-20

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

Phase 1 Recruiting

124 enrolled

Anus Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Melanoma, Neoplasm Metastasis, Ovarian Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma, Triple Negative Breast Neoplasms

NCT06638931 2026-04-15

ANTARES

BreastCNSEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETOther solid neoplasmSarcomaThoracic

28 enrolled

Urachal adenocarcinoma, Urachal cancer, Fibrolamellar hepatocellular carcinoma, Secretory breast carcinoma, Carcinoma, Ovarian Epithelial, Adrenal Gland Neoplasms, Anus Neoplasms, Biliary Tract Neoplasms, Carcinosarcoma, Carcinoma, Adenoid Cystic, Fallopian Tube Neoplasms, Fibrosarcoma, Gallbladder Neoplasms, Granulosa Cell Tumor, Hemangiosarcoma, Leiomyosarcoma, Mesothelioma, Neuroblastoma, Parathyroid Neoplasms, Penile Neoplasms, Sarcoma, Sarcoma, Kaposi, Osteosarcoma, Thyroid Neoplasms, Trophoblastic Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Hepatoblastoma, Endodermal Sinus Tumor, Neuroectodermal Tumors, Primitive, Cholangiocarcinoma, Sertoli-Leydig Cell Tumor, Neurofibrosarcoma, Hemangioblastoma, Neuroendocrine Tumors

NCT04287868 2026-04-13

Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies

GastrointestinalGynecologicHead & Neck

51 enrolled 16 charts

Anus Neoplasms, Uterine Cervical Neoplasms, Oropharyngeal Neoplasms, Rectal Neoplasms

NCT07217171 2026-04-13

A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas

Phase 1 Recruiting

160 enrolled

GastrointestinalGenitourinary

Esophageal Squamous Cell Carcinoma, Anus Neoplasms, Urinary Bladder Neoplasms

NCT07523152 2026-04-13

SAPPHIRE

Phase NA Not yet recruiting

42 enrolled

GastrointestinalGynecologic

Anal Canal Carcinoma, Anus Neoplasms, Pelvic Neoplasms, Uterine Neoplasms, Vaginal Neoplasms

NCT05858736 2026-04-09

PRESERVE-009

Phase 1 Active not recruiting

18 enrolled

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Anus Neoplasms, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Fallopian Tube Neoplasms, Carcinoma, Hepatocellular, Melanoma, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT04708470 2026-04-06

A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers

GastrointestinalGenitourinaryGynecologicHead & Neck

55 enrolled

Anus Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Oropharyngeal Neoplasms, Penile Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT04234113 2026-03-27

Study of Nanrilkefusp Alfa Alone and With Pembrolizumab in Adult Patients With Advanced/Metastatic Solid Tumors

Phase 1 Terminated

115 enrolled 43 charts

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Anus Neoplasms, Biliary Tract Neoplasms, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Melanoma, Mesothelioma, Ovarian Neoplasms, Stomach Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Carcinoma, Merkel Cell, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT06493019 2026-03-23

Study of Pembrolizumab, Carboplatin, Paclitaxel, and Radiation for the Treatment of Early-Stage Anal Cancer

23 enrolled

Phase NA Not yet recruiting

Anus Neoplasms

NCT07464236 2026-03-18

PEACHES 2

8 enrolled

Anus Neoplasms, Chlamydia Infections, Gonorrhea

NCT04094454 2026-03-10

DILANA

Phase NA Recruiting

60 enrolled

Anus Neoplasms

NCT06050707 2026-03-06

MAESTRO

80 enrolled