Clinical Trials

Appendiceal Neoplasms, Peritoneal Diseases, Peritoneal Neoplasms, Colorectal Neoplasms

NCT05913674 2026-05-14

Technical Feasibility of Modified Early Post-Operative Intraperitoneal Chemotherapy (mEPIC)

Phase 2 Recruiting

25 enrolled

Appendiceal Neoplasms, Peritoneal Neoplasms

NCT07587268 2026-05-14

Molecular Profiling for Risk Stratification in Appendiceal Cancer

400 enrolled

Appendiceal Neoplasms, Adenocarcinoma, Mucinous

NCT07283939 2026-05-11

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

420 enrolled

Appendiceal Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT04779554 2026-04-01

Flat Dose vs. Weight-based IP Chemotherapy for CRS/HIPEC

Phase 2 Recruiting

100 enrolled

Appendiceal Neoplasms, Peritoneal Neoplasms, Pseudomyxoma Peritonei, Colorectal Neoplasms

NCT07291180 2026-03-04

A Feasibility Study of Mass-Based Response Drug Screening to Guide Personalized Hyperthermic Intraperitoneal Chemotherapy for High-Grade Appendiceal and Colorectal Adenocarcinoma With Peritoneal Metastasis

20 enrolled

Appendiceal Neoplasms

NCT04907643 2026-02-20

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

EndocrineGastrointestinalNET

360 enrolled

Cancer Pain, Anus Neoplasms, Appendiceal Neoplasms, Bile Duct Neoplasms, Biliary Tract Neoplasms, Carcinoid Tumor, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Gastrointestinal Neoplasms, Liver Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Rectal Neoplasms, Recurrence, Stomach Neoplasms, Neuroendocrine Tumors, Visceral Pain

NCT01815359 2026-02-05

ICARuS

Phase 2 Active not recruiting

292 enrolled

Appendiceal Neoplasms, Colorectal Neoplasms

NCT04505553 2026-01-21

Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer

EndocrineGastrointestinalNET

78 enrolled 14 charts

Gastro-enteropancreatic neuroendocrine tumor, Anus Neoplasms, Appendiceal Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Carcinoma, Hepatocellular, Adenoma, Islet Cell, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT06715839 2025-12-31

Target-specific immunoPET Imaging of Digestive System Carcinoma

400 enrolled

Simpson-Golabi-Behmel syndrome, Appendiceal Neoplasms, Bile Duct Neoplasms, Colonic Neoplasms, Digestive System Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Gastrointestinal Neoplasms, Liver Neoplasms, Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT05472948 2025-12-17

Surufatinib and Sintilimab in Combination With Capecitabine for Metastatic Adenocarcinoma of Small Intestine or Appendix Carcinoma

Phase 2 Recruiting

36 enrolled

Appendiceal Neoplasms, Neoplasm Metastasis

NCT04329494 2025-12-10

PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer

Phase 1 Recruiting

49 enrolled

Phase 3 Not yet recruiting

Appendiceal Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Peritoneal Neoplasms, Stomach Neoplasms, Uterine Neoplasms, Colorectal Neoplasms

NCT07271355 2025-12-09

Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial

129 enrolled

Appendiceal Neoplasms, Colorectal Neoplasms

NCT04157322 2025-12-03

Plasma 5hmC Signatures as a Marker of Colorectal / Appendiceal Peritoneal Metastasis

Active not recruiting

55 enrolled

Phase NA Active not recruiting

Appendiceal Neoplasms, Colorectal Neoplasms

NCT01946854 2025-11-18

Crossover Trial of Systemic Chemotherapy in Patients With Metastatic Well-Differentiated Mucinous Appendiceal Adenocarcinomas With Pseudomyxoma Peritonei

30 enrolled

Classical hematologyGastrointestinal

Appendiceal Neoplasms, Gastrointestinal Neoplasms

NCT04526886 2025-10-06

Clinical Trial of a Novel Dose Adjustment Algorithm for Preventing Cytopenia-Related Delays During FOLFOX Chemotherapy

Phase NA Completed

52 enrolled 8 charts

Appendiceal Neoplasms, Esophageal Neoplasms, Neutropenia, Stomach Neoplasms, Thrombocytopenia, Colorectal Neoplasms

NCT05780684 2025-09-22

Individualized Dose Escalation of 5-FU for Gastrointestinal Cancer

36 enrolled

Appendiceal Neoplasms, Esophageal Neoplasms, Colorectal Neoplasms

NCT07124351 2025-09-15

Intraoperative Imaging of Gastrointestinal Malignancies Using Pafolacianine (CYTALUX™)

Phase 4 Recruiting

15 enrolled

Appendiceal Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Stomach Neoplasms

NCT05277766 2025-07-01

PIPAC-NAL-IRI

Phase 1 Recruiting

45 enrolled

Appendiceal Neoplasms, Bile Duct Neoplasms, Pancreatic Neoplasms, Peritoneal Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT05734430 2025-04-18

GAP

700 enrolled

Phase NA Active not recruiting

Appendiceal Neoplasms, Adenocarcinoma, Mucinous

NCT05623787 2025-03-20

DWI-HighRisk

30 enrolled

Appendiceal Neoplasms, Carcinoma, Peritoneal Neoplasms, Colorectal Neoplasms

NCT06101277 2025-01-06

LIVELONG

300 enrolled

Appendiceal Neoplasms, Biliary Tract Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT05364788 2025-01-01

Molecular Characterisation of Appendiceal Cancer

100 enrolled

Phase 2 Active not recruiting

Appendiceal Neoplasms

NCT02387203 2024-11-19

Antibiotic Treatment and Long-term Outcomes of Patients With Pseudomyxoma Peritonei of Appendiceal Origin

80 enrolled

Appendiceal Neoplasms, Pseudomyxoma Peritonei

NCT02040142 2024-10-24

HIPEC for Peritoneal Carcinomatosis

51 enrolled 12 charts

Appendiceal Neoplasms, Peritoneal Neoplasms, Pseudomyxoma Peritonei, Stomach Neoplasms, Colorectal Neoplasms

NCT06216561 2024-08-20

Intraperitoneal LSTA1 in CRS-HIPEC

Phase 1 Withdrawn

Appendiceal Neoplasms, Ovarian Neoplasms, Colorectal Neoplasms

NCT05919758 2024-07-30

NETkids

1,000 enrolled

Appendiceal Neoplasms, Neoplasms

NCT03510923 2024-06-04

FANCY

17,380 enrolled

Appendiceal Neoplasms, Gallbladder Neoplasms, Neoplasms

NCT05305820 2024-03-21

PANO

Phase NA Unknown

36 enrolled

Appendiceal Neoplasms, Colonic Neoplasms, Ovarian Neoplasms, Rectal Neoplasms

NCT05083338 2024-02-13

Psychological, Psychophysical and Epigenetic Determinants of Chronic Pain After Cytoreductive - Hyperthermic Intraoperative Chemotherapy

24 enrolled

Appendiceal Neoplasms, Carcinoma, Stomach Neoplasms, Colorectal Neoplasms

NCT05513183 2023-08-07

Severe Neutropenia After HIPEC Using Mitomycin-C

74 enrolled

Appendiceal Neoplasms, Pseudomyxoma Peritonei

NCT03073694 2023-06-09

Comparing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) Using Mitomycin-C Versus Melphalan for Colorectal Peritoneal Carcinomatosis

Phase 2 Unknown

100 enrolled

Appendiceal Neoplasms, Peritoneal Neoplasms, Colorectal Neoplasms

NCT02599116 2023-03-27

Gastrointestinal Microbiome Study of Appendiceal Cancer

Phase NA Unknown

24 enrolled

Appendiceal Neoplasms, Pseudomyxoma Peritonei

NCT02963831 2022-12-22

A Study to Investigate ONCOS-102 in Combination With Durvalumab in Subjects With Advanced Peritoneal Malignancies

Phase 1/2 Completed

67 enrolled 16 charts

Appendiceal Neoplasms, Ovarian Neoplasms, Colorectal Neoplasms

NCT02489422 2022-10-14

PRO-YOU

Phase NA Completed

44 enrolled 28 charts

Anus Neoplasms, Appendiceal Neoplasms, Biliary Tract Neoplasms, Colonic Neoplasms, Depression, Esophageal Neoplasms, Fatigue, Gallbladder Neoplasms, Liver Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT03287947 2022-08-09

LCI-GI-APX-NIN-001: Nintedanib in Metastatic Appendiceal Carcinoma

Phase 2 Terminated

5 enrolled 12 charts

Appendiceal Neoplasms

NCT03604653 2022-08-03

Trial of Cytoreductive Surgery and HIPEC in Patients With Primary and Secondary Peritoneal Cancers

10 enrolled

Appendiceal Neoplasms, Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Ovarian Neoplasms, Stomach Neoplasms, Uterine Neoplasms, Colorectal Neoplasms

NCT05452382 2022-07-11

Surgical Outcome and Predictors of Overall Survival of Stage I-III Appendiceal Adenocarcinoma

2,607 enrolled

Appendiceal Neoplasms

NCT02833753 2022-05-31

Trial of Intraperitoneal (IP) Oxaliplatin in Combination With Intravenous FOLFIRI

Phase 1 Completed

14 enrolled

Appendiceal Neoplasms, Peritoneal Neoplasms, Colorectal Neoplasms

NCT05202600 2022-01-21

Justification of Incidental Appendectomy With Respect to Pathohistological Findings

Unknown

1,000 enrolled

Appendiceal Neoplasms

NCT04158349 2021-09-27

IPOX-FOLFIRI

Phase 1 Terminated

1 enrolled

Appendiceal Neoplasms, Colorectal Neoplasms

NCT03246321 2019-10-15

CRC-PIPAC

20 enrolled

GastrointestinalGynecologicOther solid neoplasmThoracic

Appendiceal Neoplasms, Cecal Neoplasms, Intraoperative Complications, Neoplasms, Peritoneal Neoplasms, Postoperative Complications, Colorectal Neoplasms, Drug-Related Side Effects and Adverse Reactions

NCT03210298 2019-10-08

PIPACRegis

Unknown

1,000 enrolled

Mesothelioma, Malignant, Appendiceal Neoplasms, Ascites, Gallbladder Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Peritoneal Neoplasms, Pleural Effusion, Pseudomyxoma Peritonei, Stomach Neoplasms, Colorectal Neoplasms

NCT00003867 2018-09-10

Irinotecan and Capecitabine in Treating Patients With Solid Tumors

Phase 1 Completed

30 enrolled

BreastGastrointestinal

Anus Neoplasms, Appendiceal Neoplasms, Bile Duct Neoplasms, Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT00310076 2018-08-23

Thalidomide in Treating Patients Who Have Undergone Surgery and Chemotherapy for Cancer That Has Spread Throughout the Abdomen Due to Colorectal Cancer or Appendix Cancer

29 enrolled 9 charts

Appendiceal Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00458809 2018-08-09

Intraperitoneal Hyperthermic Perfusion With Oxaliplatin in Treating Patients With Stage IV Peritoneal Cancer Due to Appendix Cancer or Colorectal Cancer

Phase 1 Completed

16 enrolled

GastrointestinalGynecologicOther solid neoplasmThoracic

Appendiceal Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01126346 2018-07-03

HOPE

Phase NA Completed

10 enrolled

Carcinoma, Ovarian Epithelial, Mesothelioma, Malignant, Appendiceal Neoplasms, Colonic Neoplasms, Pseudomyxoma Peritonei

NCT01580410 2018-07-03

Surgery and Oxaliplatin or Mitomycin C in Treating Patients With Tumors of the Appendix

136 enrolled 14 charts

Appendiceal Neoplasms

NCT00903396 2017-11-24

Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy in Patients With Primary Abdominal Cancer

Phase 2 Terminated

7 enrolled 1 chart