Announcements Trials
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Phase

Phase 1/2 2Phase 1 2Phase 2 1

Status

Completed 2

Sponsor Class

NIH 2

Study Type

Interventional 2

Sponsor

Cancer Type

CNS 2

Conditions

Breast Neoplasms 14Ovarian Neoplasms 12Triple Negative Breast Neoplasms 6Fallopian Tube Neoplasms 6Neoplasms 5Stomach Neoplasms 4Pancreatic Neoplasms 4Neoplasm Metastasis 4Lymphoma 3Lung Neoplasms 3Colonic Neoplasms 3Breast Neoplasms, Male 3Prostatic Neoplasms 2Precursor Cell Lymphoblastic Leukemia-Lymphoma 2Melanoma 2Medulloblastoma 2Leukemia, Myelomonocytic, Chronic 2Leukemia, Myelomonocytic, Acute 2Leukemia, Myeloid, Acute 2Hereditary Breast and Ovarian Cancer Syndrome 2Carcinoma, Non-Small-Cell Lung 2Brain Neoplasms 2Astrocytoma 2Zollinger-Ellison Syndrome 1Vipoma 1Uterine Cervical Neoplasms 1Urinary Bladder Neoplasms 1Thrombocythemia, Essential 1Testicular Neoplasms 1Stage IV Fallopian Tube Cancer AJCC v6 and v7 1

Interventions

Temozolomide 38Radiotherapy 17Filgrastim 14Surgical Procedures, Operative 11Irinotecan 11Carmustine 10Carboplatin 10Radiation 9O(6)-benzylguanine 9Magnetic Resonance Spectroscopy 9Specimen Handling 7Granulocyte Colony-Stimulating Factor 7Flucytosine 7sargramostim 6Radiotherapy, Intensity-Modulated 5Peripheral Blood Stem Cell Transplantation 5Etoposide 5Erlotinib Hydrochloride 5Bevacizumab 5vocimagene amiretrorepvec 4Vorinostat 4Thiotepa 4Melphalan 4Lenalidomide 4IL13-PE38 4Genetic Therapy 4Cyclophosphamide 4Chemotherapy, Adjuvant 4Busulfan 4lonafarnib 3

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Phase 1 × Astrocytoma × veliparib × Clear all
NCT00994071 2019-12-09

A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors

National Institutes of Health Clinical Center (CC)

Phase 1 Completed
9 enrolled
CNS

Astrocytoma, Brain Neoplasms, Ependymoma, Medulloblastoma, Neuroectodermal Tumors, Primitive

NCT00946335 2014-07-09

ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors

National Cancer Institute (NCI)

Phase 1 Completed
31 enrolled
CNS

Familial ependymoma, Astrocytoma, Medulloblastoma, Oligodendroglioma, Spinal Cord Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor, Optic Nerve Glioma

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