Clinical Trials

Astrocytoma

NCT05934630 2026-04-23

Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors

Terminated

57 enrolled

Phase 1 Active not recruiting

Choroid Plexus Carcinoma, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Medulloblastoma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Rhabdoid Tumor

NCT04978727 2026-04-06

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

35 enrolled

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Ependymoma, Glioblastoma, Medulloblastoma, Oligodendroglioma

NCT04295759 2026-01-05

INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas

13 enrolled 15 charts

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Pyloric Stenosis, Hypertrophic

NCT03224104 2025-11-26

STEAM

71 enrolled 18 charts

Phase 3 Active not recruiting

Astrocytoma, Glioblastoma

NCT00978458 2025-09-08

Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma

540 enrolled

Astrocytoma, Brain Neoplasms, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Neurotoxicity Syndromes

NCT02323880 2025-01-14

Selinexor in Treating Younger Patients With Recurrent or Refractory Solid Tumors or High-Grade Gliomas

59 enrolled 20 charts

CNSLymphoid

Astrocytoma, Brain Neoplasms, Glioma, Lymphoma, Central Nervous System Neoplasms

NCT00003375 2024-07-09

Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade Glioma

Phase 2/3 Completed

370 enrolled

Astrocytoma, Oligodendroglioma, Central Nervous System Neoplasms

NCT00114140 2024-07-08

Temozolomide and Radiation Therapy in Treating Patients With Gliomas

136 enrolled 9 charts

Astrocytoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT00138216 2023-10-02

Temozolomide, Vincristine, and Irinotecan in Treating Young Patients With Refractory Solid Tumors

42 enrolled

Phase 3 Active not recruiting

Familial ependymoma, Astrocytoma, Medulloblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor, Optic Nerve Glioma

NCT00626990 2023-09-11

CATNON

751 enrolled 18 charts

Astrocytoma, Oligodendroglioma, Central Nervous System Neoplasms

NCT00100802 2023-02-15

Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed Gliomas

118 enrolled 8 charts

Astrocytoma, Glioblastoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms, Gliosarcoma

NCT02255461 2021-03-02

Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors

Phase 1 Terminated

35 enrolled 28 charts

Astrocytoma, Glioblastoma, Medulloblastoma, Oligodendroglioma, Choroid Plexus Neoplasms, Neoplasms, Neuroepithelial

NCT00036660 2020-04-06

SarCNU in Treating Patients With Recurrent Malignant Glioma

10 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT03722355 2019-11-12

Hyperfractionated RT With BCNU Versus Conventional RT With BCNU for Supratentorial Malignant Glioma

712 enrolled

Astrocytoma, Glioblastoma, Glioma

NCT00004259 2019-09-12

Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas

230 enrolled 14 charts

Astrocytoma, Glioma, Central Nervous System Neoplasms

NCT00238264 2019-08-07

Radiation Therapy in Treating Young Patients With Gliomas

92 enrolled 12 charts

Astrocytoma, Brain Neoplasms, Oligodendroglioma, Central Nervous System Neoplasms, Optic Nerve Glioma

NCT01164189 2019-02-28

TAVAREC

155 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT01836549 2018-07-20

Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors

Phase 2 Terminated

43 enrolled 14 charts

Astrocytoma, Ependymoma, Glioblastoma, Oligodendroglioma, Gliosarcoma, Brain Stem Neoplasms

NCT00919750 2018-07-16

Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors

1,258 enrolled

Familial ependymoma, Astrocytoma, Ependymoma, Medulloblastoma, Oligodendroglioma, Choroid Plexus Neoplasms, Rhabdoid Tumor, Optic Nerve Glioma

NCT01975116 2017-08-07

p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors

18 enrolled

Teratoid Tumor, Atypical, Astrocytoma, Glioblastoma, Medulloblastoma, Oligodendroglioma, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Gliosarcoma, Brain Stem Neoplasms

NCT01026493 2017-07-02

Veliparib and Temozolomide in Treating Patients With Recurrent Glioblastoma

Phase 1/2 Completed

257 enrolled 16 charts

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00182819 2016-10-12

Radiation Therapy or Temozolomide in Treating Patients With Gliomas

709 enrolled

Astrocytoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT02031965 2016-05-30

Oncolytic HSV-1716 in Treating Younger Patients With Refractory or Recurrent High Grade Glioma That Can Be Removed By Surgery

Phase 1 Terminated

2 enrolled

Astrocytoma, Glioblastoma, Oligodendroglioma, Neoplasms, Neuroepithelial

NCT00890435 2015-10-21

Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial

CNSLymphoidOther hematologic neoplasm

53 enrolled

Familial ependymoma, Congenital Abnormalities, Astrocytoma, Brain Neoplasms, Craniopharyngioma, Glioma, Leukemia, Leukemia, Hairy Cell, Leukemia, Mast-Cell, Medulloblastoma, Meningeal Neoplasms, Meningioma, Oligodendroglioma, Pinealoma, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Biphenotypic, Acute, Leukemia, Prolymphocytic, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Optic Nerve Glioma, Leukemia, Large Granular Lymphocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative

NCT00078988 2015-05-07

High-Dose Chemotherapy Plus Autologous Stem Cell Transplantation Compared With Intermediate-Dose Chemotherapy Plus Autologous Stem Cell Transplantation With or Without Isotretinoin in Treating Young Patients With Recurrent High-Grade Gliomas

1 enrolled

Astrocytoma, Brain Neoplasms, Central Nervous System Neoplasms

NCT01158300 2015-05-04

PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors

28 enrolled

Familial ependymoma, Astrocytoma, Medulloblastoma, Meningioma, Oligodendroglioma, Spinal Cord Neoplasms, Central Nervous System Neoplasms, Optic Nerve Glioma

NCT01417507 2015-03-18

Natural History of Brain Function, Quality of Life, and Seizure Control in Patients With Brain Tumor Who Have Undergone Surgery

82 enrolled

CNSGastrointestinalGenitourinaryGynecologic

Astrocytoma, Glioma, Oligodendroglioma, Seizures, Neurotoxicity Syndromes

NCT00023634 2015-03-06

S0114 Vaccine Therapy in Treating Patients With Gastric, Prostate, or Ovarian Cancer

Phase 1 Terminated

14 enrolled

Carcinoma, Ovarian Epithelial, Astrocytoma, Brain Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Stomach Neoplasms

NCT00083096 2015-02-10

Lonafarnib and Temozolomide in Treating Patients With Recurrent Primary Supratentorial Gliomas

Phase 1 Unknown

30 enrolled

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Glioma, Subependymal, Gliosarcoma

NCT00516607 2015-02-10

Enzastaurin and Temozolomide in Treating Patients With Primary Gliomas

Phase 1 Unknown

28 enrolled

CNSLymphoidOther hematologic neoplasmSarcoma

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00458744 2014-08-08

Talotrexin in Treating Young Patients With Recurrent Solid Tumors or Leukemia That is Recurrent or Does Not Respond to Treatment

Phase 1 Withdrawn

Familial ependymoma, Astrocytoma, Burkitt Lymphoma, Leukemia, Lymphoma, Medulloblastoma, Recurrence, Spinal Cord Neoplasms, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Optic Nerve Glioma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Leukemia, Myelomonocytic, Juvenile, Dendritic Cell Sarcoma, Interdigitating

NCT00107458 2014-08-07

Valproic Acid in Treating Young Patients With Recurrent or Refractory Solid Tumors or CNS Tumors

26 enrolled

Familial ependymoma, Astrocytoma, Medulloblastoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms, Optic Nerve Glioma

NCT00003234 2014-07-28

Vinorelbine in Treating Children With Recurrent or Refractory Cancers

50 enrolled

Familial ependymoma, Astrocytoma, Neuroblastoma, Sarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral

NCT00003597 2014-07-24

Colony-Stimulating Factors in Treating Children With Recurrent or Refractory Solid Tumors

CNSClassical hematologyDermatologicGenitourinaryGynecologicOther solid neoplasmSarcoma

16 enrolled

Uveal Melanoma, Astrocytoma, Carcinoma, Renal Cell, Medulloblastoma, Melanoma, Neoplasms, Wilms Tumor, Neuroblastoma, Neutropenia, Retinoblastoma, Osteosarcoma, Testicular Neoplasms, Thrombocytopenia, Neuroectodermal Tumors, Primitive, Peripheral, Optic Nerve Glioma, Gestational Trophoblastic Disease

NCT00003141 2014-03-28

Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors

94 enrolled

Astrocytoma, Brain Neoplasms, Neuroblastoma, Sarcoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor

NCT00028795 2014-02-21

Chemotherapy and Radiation Therapy After Surgery in Treating Children With Newly Diagnosed Astrocytoma, Glioblastoma Multiforme, Gliosarcoma, or Diffuse Intrinsic Pontine Glioma

170 enrolled

Astrocytoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT00002485 2014-02-14

Development of Strategies to Increase Enrollment in Clinical Trials for Children With Cancer

CNSGastrointestinalGenitourinaryGynecologicLymphoidOther hematologic neoplasmSarcoma

359 enrolled

Familial ependymoma, Ovarian Germ Cell Cancer, Astrocytoma, Burkitt Lymphoma, Leukemia, Liver Neoplasms, Lymphoma, Medulloblastoma, Meningioma, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Recurrence, Sarcoma, Osteosarcoma, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Hepatoblastoma, Rhabdoid Tumor, Optic Nerve Glioma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Dendritic Cell Sarcoma, Interdigitating

NCT00006024 2014-02-13

Temozolomide Plus Lomustine Followed by Radiation Therapy in Treating Patients With High-Grade Malignant Glioma

32 enrolled

Astrocytoma, Brain Neoplasms, Central Nervous System Neoplasms

NCT00352495 2014-02-13

Vinblastine and Carboplatin in Treating Young Patients With Newly Diagnosed or Recurrent Low-Grade Glioma

26 enrolled

Astrocytoma, Neurofibromatosis 1, Oligodendroglioma, Central Nervous System Neoplasms, Optic Nerve Glioma

NCT01273090 2014-01-30

Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma

CNSDermatologicLymphoidSarcoma

34 enrolled

Astrocytoma, Burkitt Lymphoma, Glioblastoma, Hodgkin Disease, Immunoblastic Lymphadenopathy, Lymphoma, Lymphoproliferative Disorders, Mycosis Fungoides, Oligodendroglioma, Recurrence, Sezary Syndrome, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, T-Cell, Peripheral, Central Nervous System Neoplasms, Lymphoma, Large-Cell, Anaplastic, Neoplasms, Neuroepithelial, Optic Nerve Glioma, Lymphoma, Extranodal NK-T-Cell, Dendritic Cell Sarcoma, Interdigitating, Intraocular Lymphoma

NCT00002944 2013-09-09

Combination Chemotherapy in Treating Children With Progressive Brain Tumors

428 enrolled

Astrocytoma, Brain Neoplasms, Central Nervous System Neoplasms, Optic Nerve Glioma

NCT00004078 2013-06-14

Irinotecan in Treating Children With Refractory Solid Tumors

181 enrolled

Familial ependymoma, Astrocytoma, Medulloblastoma, Neuroblastoma, Oligodendroglioma, Osteosarcoma, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Optic Nerve Glioma

NCT00897858 2013-04-19

Studying Cerebrospinal Fluid Proteins and Angiogenesis Proteins in Young Patients With Newly Diagnosed Central Nervous System Tumors

Withdrawn

Astrocytoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor

NCT00357253 2013-01-10

Capecitabine and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Nonmetastatic Brain Stem Glioma or High-Grade Glioma

24 enrolled

Astrocytoma, Central Nervous System Neoplasms

NCT00003916 2012-09-24

Standard Radiation Therapy With or Without Stereotactic Radiation Therapy in Treating Patients With Glioma

25 enrolled

Astrocytoma, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00039364 2012-07-24

Imatinib Mesylate in Treating Patients With Gliomas

112 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Glioma, Subependymal, Gliosarcoma

NCT00002620 2012-07-02

Radiation Therapy in Treating Patients With Brain Cancer

212 enrolled

Astrocytoma, Central Nervous System Neoplasms

NCT00503724 2012-03-06

Enzastaurin in Treating Young Patients With Refractory Primary CNS Tumors

32 enrolled