Clinical Trials

GastrointestinalGenitourinaryThoracic

99 enrolled

Biliary Tract Neoplasms, Urinary Bladder Neoplasms, Lung Neoplasms, Pancreatic Neoplasms

NCT05835778 2026-01-14

Imfinzi BTC Japan PMS_Japan Post-Marketing Surveillance (PMS) Study - CEI/SCEI

236 enrolled

Biliary Tract Neoplasms

NCT03797326 2025-11-17

LEAP-005

BreastCNSGastrointestinalGynecologic

611 enrolled 27 charts

Parkinson Disease 4, Autosomal Dominant Lewy Body, Biliary Tract Neoplasms, Glioblastoma, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT04068168 2025-11-17

Imfinzi PMS

712 enrolled

GastrointestinalThoracic

Biliary Tract Neoplasms, Lung Neoplasms

NCT02576431 2025-11-12

NAVIGATE

BreastDermatologicGastrointestinalHead & NeckSarcomaThoracic

215 enrolled 5 FDA

Biliary Tract Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasms, Salivary Gland Neoplasms, Sarcoma, Thyroid Neoplasms, Colorectal Neoplasms

NCT04466891 2025-09-15

HERIZON-BTC-01

87 enrolled 25 charts 3 FDA

Biliary Tract Neoplasms, Gallbladder Neoplasms

NCT03929666 2025-09-12

A Safety and Efficacy Study of ZW25 (Zanidatamab) Plus Combination Chemotherapy in HER2-expressing Gastrointestinal Cancers, Including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer, and Colorectal Cancer

74 enrolled

Biliary Tract Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT03314935 2025-08-12

A Phase 1/2 Study of INCB001158 in Combination With Chemotherapy in Subjects With Solid Tumors

GastrointestinalGynecologic

149 enrolled 35 charts

Biliary Tract Neoplasms, Ovarian Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT05253053 2025-06-12

To Evaluate Efficacy and Safety of TT-00420 (Tinengotinib) as Monotherapy and Combination Therapy in Patients With Advanced Solid Tumors

BreastGastrointestinalGenitourinaryHead & NeckThoracic

84 enrolled

Biliary Tract Neoplasms, Urinary Bladder Neoplasms, Gallbladder Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Cholangiocarcinoma, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT05924880 2025-04-22

TopDouble

Phase 3 Completed

116 enrolled

Biliary Tract Neoplasms

NCT04907851 2025-03-17

KEYNOTE-E86

45 enrolled 25 charts

Biliary Tract Neoplasms, Pancreatic Neoplasms, Cholangiocarcinoma

NCT03447470 2025-01-29

Study to Evaluate the Safety and Tolerability of RXC004 in Advanced Malignancies

46 enrolled 29 charts

Biliary Tract Neoplasms, Neoplasms, Thymus Neoplasms

NCT05462314 2025-01-28

Intestinal Microbiome, Oral Microbiome, and Whole Blood Transcriptome Analyses in Gastrointestinal Malignancies

24 enrolled

Biliary Tract Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Liver Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT04338685 2024-12-09

A Study Evaluating Safety, Pharmacokinetics, Pharmacodynamics, And Clinical Activity Of RO7119929 (TLR7 Agonist) In Participants With Unresectable Advanced Or Metastatic Hepatocellular Carcinoma, Biliary Tract Cancer, Or Solid Tumors With Hepatic Metastases

55 enrolled 30 charts

Biliary Tract Neoplasms, Carcinoma, Hepatocellular

NCT05712889 2024-11-15

Phase 1 Dose Escalation Study for VIP236 in Patients With Advanced Cancer

BreastGastrointestinalGynecologicThoracic

29 enrolled

Biliary Tract Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Stomach Neoplasms, Endometrial Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT02443324 2024-07-31

A Study of Ramucirumab Plus Pembrolizumab in Participants With Gastric or GEJ Adenocarcinoma, NSCLC, Transitional Cell Carcinoma of the Urothelium, or Biliary Tract Cancer

GastrointestinalGenitourinaryThoracic

175 enrolled 23 charts

Biliary Tract Neoplasms, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Transitional Cell, Ureteral Neoplasms, Urethral Neoplasms

NCT02091141 2024-07-23

My Pathway: A Study Evaluating Herceptin/Perjeta, Tarceva, Zelboraf/Cotellic, Erivedge, Alecensa, and Tecentriq Treatment Targeted Against Certain Molecular Alterations in Participants With Advanced Solid Tumors

GastrointestinalGenitourinary

673 enrolled 22 charts

Biliary Tract Neoplasms, Urinary Bladder Neoplasms, Neoplasms

NCT04677504 2024-07-03

A Study of Atezolizumab With or Without Bevacizumab in Combination With Cisplatin Plus Gemcitabine in Patients With Untreated, Advanced Biliary Tract Cancer

162 enrolled 18 charts

Biliary Tract Neoplasms

NCT05074472 2024-01-29

A Phase 1/2, First-in-Human, Open Label, Dose Escalation Study Of A CSP Targeting Functional Antibody in Solid Tumors

GastrointestinalGynecologic

35 enrolled

Adenocarcinoma, Biliary Tract Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms

NCT03230318 2023-12-19

FIDES-01

148 enrolled 15 charts

Bile Duct Neoplasms, Biliary Tract Neoplasms, Liver Neoplasms, Cholangiocarcinoma

NCT03531320 2023-11-24

Study of D07001-Softgel Capsules in Subjects With Gastrointestinal Cancer in Dose-Escalation Phase and in Subjects With Biliary Tract Cancer in Dose-Expansion Phase

19 enrolled 13 charts

Biliary Tract Neoplasms, Gastrointestinal Neoplasms

NCT03833661 2023-10-25

M7824 Monotherapy in Locally Advanced or Metastatic Second Line (2L) Biliary Tract Cancer (Cholangiocarcinoma and Gallbladder Cancer)

159 enrolled 23 charts

Biliary Tract Neoplasms, Camurati-Engelmann Syndrome, Gallbladder Neoplasms, Cholangiocarcinoma

NCT02034110 2023-08-21

Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare Cancers

206 enrolled 40 charts 4 FDA

CNSEndocrineGastrointestinalHead & NeckOther hematologic neoplasmPlasma cellSarcoma

Nonseminomatous germ cell tumor, Biliary Tract Neoplasms, Glioma, Leukemia, Hairy Cell, Multiple Myeloma, Neoplasms, Gastrointestinal Stromal Tumors, Thyroid Carcinoma, Anaplastic

NCT05116891 2023-07-03

A Phase 1/2 Study of CAN04 in Combination With Different Chemotherapy Regimens in Subjects With Advanced Solid Tumors

40 enrolled

GastrointestinalThoracic

Biliary Tract Neoplasms, Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms

NCT01752920 2023-06-05

Phase 1/2 Study of Derazantinib (ARQ 087) in Adult Subjects With Advanced Solid Tumors With FGFR Genetic Alterations

119 enrolled 15 charts

Biliary Tract Neoplasms, Liver Neoplasms, Neoplasms, Cholangiocarcinoma

NCT01899976 2022-04-13

X-MAS Biliary Study With Covered Biliary Stent

Phase NA Completed

68 enrolled

Biliary Tract Neoplasms

NCT03937895 2022-03-29

Allogeneic NK Cell ("SMT-NK") in Combination With Pembrolizumab in Advanced Biliary Tract Cancer

40 enrolled

Biliary Tract Neoplasms, Cholangiocarcinoma

NCT02128282 2021-10-22

Study of CX-4945 in Combination With Gemcitabine and Cisplatin for Frontline Treatment of Cholangiocarcinoma

127 enrolled

Bile Duct Neoplasms, Biliary Tract Neoplasms, Cholangiocarcinoma

NCT01938612 2021-03-12

A Phase I, Open-Label, Multicentre Study to Evaluate the Safety, Tolerability and Pharmacokinetics of MEDI4736 in Patients With Advanced Solid Tumours

GastrointestinalHead & Neck

269 enrolled

Squamous Cell Carcinoma of Head and Neck, Biliary Tract Neoplasms

NCT02579616 2020-12-23

Study of Lenvatinib (E7080) in Unresectable Biliary Tract Cancer (BTC) Who Failed Gemcitabine-based Combination Chemotherapy

29 enrolled 16 charts

Biliary Tract Neoplasms

NCT00959127 2020-09-16

A Study of ARRY-438162 (MEK162) in Patients With Advanced Cancer

93 enrolled

Biliary Tract Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02586987 2019-11-18

A Study to Assess the Safety, Tolerability and Anti-tumour Activity of Ascending Doses of Selumetinib in Combination With MEDI4736 and Selumetinib in Combination With MEDI4736 and Tremelimumab in Patients With Advanced Solid Tumours

BreastDermatologicGastrointestinalThoracic

58 enrolled

Biliary Tract Neoplasms, Breast Neoplasms, Lung Neoplasms, Melanoma, Colorectal Neoplasms, Disease Progression

NCT02966821 2019-02-27

Study of Surufatinib as Second-line Treatment in Patients With Biliary Tract Carcinoma

39 enrolled

Biliary Tract Neoplasms

NCT01324258 2017-11-13

Trial of GSK1120212 and GSK1120212 in Combination With GEM in Japanese Subjects With Solid Tumors

19 enrolled

GastrointestinalThoracic

Biliary Tract Neoplasms, Carcinoma, Non-Small-Cell Lung, Pancreatic Neoplasms

NCT01943864 2017-05-31

A Phase IIa Study of the MEK Inhibitor Trametinib Monotherapy in the Treatment of Biliary Tract Cancers

20 enrolled 27 charts

Biliary Tract Neoplasms, Neoplasms

NCT00753675 2016-10-10

VANGOGH

174 enrolled 12 charts

Biliary Tract Neoplasms, Gallbladder Neoplasms, Cholangiocarcinoma

NCT01962168 2015-04-08

Evolution® Biliary Stent System Clinical Study

113 enrolled

Biliary Tract Neoplasms, Digestive System Diseases, Gastrointestinal Diseases, Neoplasms

NCT00174564 2012-02-17

EXIBIT: Oxaliplatin in Biliary Tract Cancer

67 enrolled

Biliary Tract Neoplasms

NCT00196105 2011-10-03

Malignant Obstruction ZILVER Against Routine Therapy (MOZART I)

Phase NA Completed

241 enrolled 15 charts

Biliary Tract Neoplasms, Jaundice, Pancreatic Neoplasms, Jaundice, Obstructive

NCT00779688 2011-02-10

A Registry of Patients Undergoing Cellvizio Endomicroscopy and Endoscopic Retrograde Cholangiopancreatography(ERCP) Imaging Procedures for Diagnosing Pancreatic and Bile Duct Cancers

130 enrolled

Bile Duct Neoplasms, Biliary Tract Neoplasms, Pancreatic Neoplasms

NCT00423254 2010-08-03

Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-PP) for Patients With Advanced Cancer.

BreastDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

12 enrolled

Anus Neoplasms, Biliary Tract Neoplasms, Bone Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Liver Neoplasms, Melanoma, Mesothelioma, Pancreatic Neoplasms, Sarcoma, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms, Endometrial Neoplasms, Carcinoma, Neuroendocrine, Small Cell Lung Carcinoma

NCT00380588 2009-11-20

Randomized Phase 2 Study With Gemcitabine Alone and Combination Therapy for Patients With Advanced Biliary Tract Cancer

84 enrolled 16 charts