Clinical Trials

Phase 2 Active not recruiting

Bone Neoplasms, Osteoporosis

NCT03678883 2026-04-03

9-ING-41 in Patients With Advanced Cancers

350 enrolled

BreastCNSGastrointestinalGenitourinaryLymphoidOther hematologic neoplasmSarcomaThoracic

Bone Neoplasms, Breast Neoplasms, Glioma, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Neoplasm Metastasis, Neoplasms, Hereditary Sensory and Autonomic Neuropathies, Pancreatic Neoplasms, Sarcoma, Colorectal Neoplasms, Leukemia-Lymphoma, Adult T-Cell

NCT06453642 2026-03-30

GPX

Phase NA Active not recruiting

114 enrolled

GenitourinarySarcoma

Bone Neoplasms, Carcinoma, Renal Cell, Angiomyolipoma, Vascular Neoplasms

NCT07379008 2026-01-30

Safety and Efficacy of Non-Setting Paste in Bone Defect Reconstruction

29 enrolled

Bone Cysts, Bone Diseases, Bone Neoplasms, Enchondromatosis

NCT06376682 2025-09-22

EPIBONE

34 enrolled 11 charts

Phase 2 Active not recruiting

Bone Neoplasms, Fractures, Bone

NCT04974008 2025-01-22

OST-164-01

39 enrolled

Phase 2 Active not recruiting

Bone Neoplasms, Osteosarcoma

NCT03709680 2025-01-14

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

128 enrolled

CNSSarcoma

Diffuse Intrinsic Pontine Glioma, Bone Neoplasms, Medulloblastoma, Neoplasms, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Rhabdoid Tumor

NCT01896505 2024-01-08

A Phase I Trial to Assess the Effects of Food and Formulation on PK of KPT-330 in Patients With Sarcoma

54 enrolled 28 charts

Phase EARLY_PHASE1 Recruiting

Bone Neoplasms, Sarcoma

NCT06171282 2023-12-14

A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Advanced Bone and Soft Tissue Tumors

9 enrolled

GastrointestinalHead & NeckSarcoma

Bone Neoplasms, Sarcoma, Osteosarcoma

NCT03525392 2023-12-12

Study to Evaluate the Safety and Activity (Including Distribution) of 177Lu-3BP-227 in Subjects With Solid Tumours Expressing Neurotensin Receptor Type 1.

Phase 1 Terminated

14 enrolled 20 charts

Squamous Cell Carcinoma of Head and Neck, Bone Neoplasms, Neoplasm Metastasis, Recurrence, Stomach Neoplasms, Colorectal Neoplasms

NCT02736565 2023-11-13

Pbi-shRNA™ EWS/FLI1 Type 1 LPX in Subjects With Advanced Ewing's Sarcoma

7 enrolled

Bone Neoplasms, Sarcoma, Sarcoma, Ewing, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Peripheral, Neuroectodermal Tumors, Primitive, Rare Diseases

NCT04788147 2023-10-31

BIOGUIDE-X

30 enrolled 17 charts

SarcomaThoracic

Bone Neoplasms, Lung Neoplasms, Neoplasms

NCT06008483 2023-08-23

A Dose Finding Study to Treat Bone Tumor(s)

Phase 1 Unknown

17 enrolled

Phase EARLY_PHASE1 Unknown

Bone Neoplasms

NCT05851456 2023-05-09

A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Bone and Soft Tissue Tumors

20 enrolled

Bone Neoplasms, Sarcoma, Osteosarcoma

NCT05732558 2023-03-09

Augmented Reality Navigation System (Endosight) for the Guidance of Bone Biopsy

16 enrolled

Bone Neoplasms

NCT01345019 2022-11-08

Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma

Other hematologic neoplasmPlasma cellSarcoma

1,718 enrolled 22 charts

Blood Protein Disorders, Bone Diseases, Bone Marrow Diseases, Bone Neoplasms, Hematologic Diseases, Multiple Myeloma, Neoplasm Metastasis, Neoplasms, Neoplastic Processes, Paraproteinemias, Spinal Cord Compression, Hematologic Neoplasms, Fractures, Bone, Neoplasms, Plasma Cell

NCT00095017 2022-02-16

Safety and Efficacy of an Investigational Drug Versus Placebo in the Treatment of Cancer Pain (0663-083)

Phase 2 Withdrawn

Bone Neoplasms

NCT01461252 2021-07-16

Safety and Efficacy of Cryoablation Combined With Radiation Therapy for the Palliation of Painful Bone Metastases

Phase 1 Withdrawn

Bone Neoplasms, Neoplasm Metastasis, Pain

NCT01461265 2021-07-16

Safety and Efficacy of Cryoablation for the Palliation of Painful Bone Metastases

29 enrolled

Bone Neoplasms, Neoplasm Metastasis, Pain

NCT04798326 2021-03-15

MW032

120 enrolled

Bone Neoplasms

NCT00381095 2021-01-20

COPE

Phase 4 Terminated

152 enrolled 14 charts

Bone Neoplasms, Neoplasms, Pain, Intractable

NCT02223052 2020-05-12

Bioequivalence & Food Effect Study in Patients With Solid Tumor or Hematologic Malignancies

BreastCNSDermatologicGenitourinaryGynecologicHead & NeckLymphoidMyeloidOther hematologic neoplasmPlasma cellSarcomaThoracic

89 enrolled

Urinary Bladder Neoplasms, Bone Neoplasms, Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Glioblastoma, Hodgkin Disease, Kidney Neoplasms, Leukemia, Lung Neoplasms, Lymphoma, Lymphoma, Non-Hodgkin, Melanoma, Multiple Myeloma, Myelodysplastic Syndromes, Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Sarcoma, Osteosarcoma, Skin Neoplasms, Testicular Neoplasms, Thyroid Neoplasms, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Small Cell Lung Carcinoma

NCT00981578 2020-03-11

ExAblate Conformal Bone System Treatment of Metastatic Bone Tumors for the Palliation of Pain

Phase NA Terminated

37 enrolled 10 charts

BreastGenitourinarySarcomaThoracic

Cancer Pain, Bone Neoplasms, Breast Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Prostatic Neoplasms

NCT00656305 2020-02-05

ExAblate (MRgFUS) Treatment of Metastatic Bone Tumors for the Palliation of Pain

BreastGenitourinaryPlasma cellSarcomaThoracic

147 enrolled 12 charts

Cancer Pain, Bone Neoplasms, Breast Neoplasms, Lung Neoplasms, Multiple Myeloma, Neoplasm Metastasis, Neoplasms, Prostatic Neoplasms

NCT04178044 2019-11-26

Phase Ⅰ Clinical Study Protocol of GB223 Monoclonal Antibody Injection

Phase 1 Unknown

44 enrolled

Bone Neoplasms

NCT02274623 2019-09-27

Effect of CTAP101 Capsules on Ca/iPTH in Advanced Breast/Prostate Cancer Patients Treated With Denosumab/Zoledronic Acid

BreastGenitourinaryHead & NeckSarcoma

33 enrolled

Bone Neoplasms, Breast Neoplasms, Hyperparathyroidism, Secondary, Hypocalcemia, Prostatic Neoplasms

NCT03527888 2019-05-21

Study of Anlotinib in Patients With Primary Malignant Bone Tumors

Phase 2 Unknown

40 enrolled

Bone Neoplasms

NCT01091883 2019-03-13

Study Comparing the Safety and Effectiveness of Magnetic Resonance Guided Focused Ultrasound (MRgFUS) and External Beam Radiation (EBRT) for Treatment of Metastatic Bone Tumors and Multiple Myeloma

BreastGenitourinarySarcomaThoracic

60 enrolled

Cancer Pain, Bone Neoplasms, Breast Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Pain, Prostatic Neoplasms

NCT00960063 2018-08-27

A Study of Robatumumab (SCH 717454, MK-7454) in Combination With Different Treatment Regimens in Pediatric Participants With Advanced Solid Tumors (P05883, MK-7454-006)

Phase 1 Terminated

4 enrolled 8 charts

CNSGenitourinarySarcoma

Bone Neoplasms, Carcinoma, Renal Cell, Neoplasms, Neuroblastoma

NCT03547557 2018-06-06

BM005

10 enrolled

Bone Neoplasms

NCT00211211 2017-12-08

FREE Study - Fracture Reduction Evaluation

300 enrolled

Plasma cellSarcoma

Back Pain, Bone Diseases, Metabolic, Bone Neoplasms, Multiple Myeloma, Osteoporosis

NCT00099177 2017-08-16

A Study to Assess the Efficacy of Intravenous/Oral Bondronat (Ibandronate) in Patients With Metastatic Bone Disease Experiencing Moderate to Severe Pain

Phase 3 Terminated

96 enrolled

Bone Neoplasms, Neoplasm Metastasis, Pain

NCT00099203 2017-08-16

A Study to Assess the Efficacy of Intravenous Bondronat (Ibandronate) in Patients With Malignant and Painful Bone Disease

Phase 3 Terminated

163 enrolled

Bone Neoplasms, Neoplasm Metastasis, Pain

NCT00478270 2017-08-16

A Study of Loading Doses of Intravenous Bondronat (Ibandronate) in Patients With Breast Cancer and Metastatic Bone Disease.

Phase 2 Withdrawn

Bone Neoplasms, Neoplasm Metastasis, Pain

NCT02293031 2017-03-07

Gene-activated Matrix for Bone Tissue Repair in Maxillofacial Surgery

Phase NA Unknown

12 enrolled

Bone Neoplasms, Jaw Fractures, Alveolar Bone Loss

NCT00434447 2017-02-27

Long Term Efficacy and Safety of Zoledronic Acid Treatment in Patients With Bone Metastases

BreastGenitourinaryPlasma cellSarcoma

73 enrolled

Bone Neoplasms, Breast Neoplasms, Multiple Myeloma, Prostatic Neoplasms, Renal Insufficiency

NCT01640847 2017-02-07

MRI Guided High Intensity Focused Ultrasound (HIFU) and ThermoDox for Palliation of Painful Bone Metastases

Phase 2 Withdrawn

BreastSarcomaThoracic

Adenocarcinoma, Bone Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Small Cell Lung Carcinoma

NCT02561039 2016-11-02

A Study of Ibandronate (Bondronat) in Participants With Malignant Bone Disease

97 enrolled

Bone Neoplasms, Neoplasm Metastasis, Pain

NCT02564107 2016-11-02

A Study of Ibandronate (Bondronat) in Participants With Metastatic Bone Disease

48 enrolled

Bone Neoplasms, Neoplasm Metastasis, Pain

NCT02716792 2016-03-23

A Study to Evaluate Renal Safety of Intravenous Ibandronate (Bondronat) in Participants With Metastatic Bone Disease Due to Breast Cancer

334 enrolled

Bone Neoplasms, Neoplasm Metastasis, Pain

NCT01085565 2016-03-08

Focused Ultrasound Surgery in the Treatment of Pain Resulting From Metastatic Bone Tumors With the ExAblate 2100 Conformal Bone System

BreastGenitourinarySarcomaThoracic

50 enrolled

Cancer Pain, Bone Neoplasms, Breast Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Pain, Prostatic Neoplasms

NCT02553707 2015-09-17

A Study to Assess the Short Term Efficacy of Intravenous Ibandronate (Bondronat) in Participants With Metastatic Bone Pain Due to Breast Cancer

182 enrolled

Bone Neoplasms, Neoplasm Metastasis, Pain

NCT00538239 2015-02-13

SUCCEED

711 enrolled

Bone Neoplasms, Sarcoma

NCT00502736 2014-01-22

A Study of Loading Doses of Intravenous Bondronat (Ibandronate) in Patients With Breast Cancer and Malignant Bone Disease.

13 enrolled

Bone Neoplasms, Neoplasm Metastasis, Pain

NCT01310816 2013-12-05

A Safety and Efficacy Study of Patients With Metastatic or Locally Advanced (Unresectable) Chondrosarcoma

105 enrolled

Bone Neoplasms

NCT00558272 2013-05-27

Study to Evaluate the Safety and Effects AZD0530 on Prostate and Breast Cancer Subjects With Metastatic Bone Disease

BreastGenitourinarySarcoma

139 enrolled 23 charts

Bone Diseases, Bone Neoplasms, Breast Neoplasms, Prostatic Neoplasms

NCT00350233 2012-09-17

MR Guided Focused Ultrasound Surgery of Metastatic Bone Tumors

GenitourinarySarcomaThoracic

10 enrolled

Bone Neoplasms, Lung Neoplasms, Prostatic Neoplasms

NCT00423254 2010-08-03

Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-PP) for Patients With Advanced Cancer.

BreastDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

12 enrolled

Anus Neoplasms, Biliary Tract Neoplasms, Bone Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Liver Neoplasms, Melanoma, Mesothelioma, Pancreatic Neoplasms, Sarcoma, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms, Endometrial Neoplasms, Carcinoma, Neuroendocrine, Small Cell Lung Carcinoma

NCT00035620 2010-02-26

Pegfilgrastim as Support to Pediatric Sarcoma Patients Receiving Chemotherapy

44 enrolled