Clinical Trials Browser

NIH × Brain Neoplasms × 1 year × Clear all

NCT05588141 2026-06-05

A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

Phase 1/2 Recruiting

Brain Neoplasms, Glioma, Neoplasms, Recurrence

NCT07416188 2026-06-05

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

Phase 1/2 Recruiting

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neoplasms by Histologic Type, Neoplasms, Nerve Tissue, Recurrence, Central Nervous System Neoplasms

NCT00060541 2026-06-01

Evaluation and Treatment of Neurosurgical Disorders

Brain Neoplasms, Epilepsy, Nervous System Diseases, Parkinson Disease, Pituitary Neoplasms, Spinal Cord Neoplasms

NCT01445288 2026-05-29

Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Medulloblastoma, Central Nervous System Neoplasms, Germinoma, Neuroectodermal Tumors, Primitive, Neurotoxicity Syndromes

NCT02639325 2026-05-29

Tumor Related Epilepsy

Brain Neoplasms, Epilepsy, Neoplasms, Seizures

NCT02971501 2026-05-29

Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases

Phase 2 Active not recruiting

5 enrolled 9 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT03251989 2026-05-29

Rare CNS Tumors Outcomes &Risk

Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT04250545 2026-05-26

Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer

Phase 1 Active not recruiting

22 enrolled 14 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Neoplasms

NCT01875601 2026-05-22

NK White Blood Cells and Interleukin in Children and Young Adults With Advanced Solid Tumors

Phase 1 Completed

Brain Neoplasms, Neuroblastoma, Sarcoma

NCT07374692 2026-05-22

Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors

Phase NA Recruiting

Brain Neoplasms, Glioma, Central Nervous System Neoplasms

NCT01445483 2026-05-19

Neuropsychological Changes in Patients Receiving Radiation Therapy for Brain Metastases

Brain Neoplasms, Neoplasm Metastasis, Neoplasms

NCT02359565 2026-05-13

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

Phase 1 Active not recruiting

CNSGastrointestinal

Familial ependymoma, Turcot syndrome, Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Ependymoma, Glioma, Medulloblastoma

NCT06161519 2026-05-13

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

Phase 1/2 Recruiting

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Recurrence

NCT00268385 2026-05-07

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

Phase 1 Active not recruiting

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT02993146 2026-04-30

Ropidoxuridine and Whole Brain Radiation Therapy in Treating Patients With Brain Metastases

Phase 1 Active not recruiting

11 enrolled 12 charts

CNSOther hematologic neoplasm

Brain Neoplasms, Hematologic Neoplasms

NCT02589522 2026-04-29

Testing the Safety of M6620 (VX-970) When Given With Standard Whole Brain Radiation Therapy for the Treatment of Brain Metastases From Non-small Cell Lung Cancer, Small Cell Lung Cancer, or Neuroendocrine Tumors

Phase 1 Active not recruiting

15 enrolled 10 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Small Cell Lung Carcinoma

NCT04460937 2026-04-29

Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers

Phase 1 Active not recruiting

4 enrolled 9 charts

CNSGastrointestinal

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Brain Neoplasms, Meningeal Carcinomatosis

NCT04817254 2026-04-17

Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

Phase 2 Completed

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT02015117 2026-04-13

Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases

Phase 1 Active not recruiting

Brain Neoplasms

NCT02153957 2026-04-08

Trial Evaluating an Enhanced Physical Activity Intervention to Improve Cognitive Late Effects in Children Treated With Cranial Radiation for Brain Tumors

Phase 2 Completed

Brain Neoplasms, Motor Activity

NCT02595905 2026-04-08

Cisplatin With or Without Veliparib in Treating Patients With Recurrent or Metastatic Triple-Negative and/or BRCA Mutation-Associated Breast Cancer With or Without Brain Metastases

Phase 2 Completed

344 enrolled 11 charts

Brain Neoplasms, Breast Neoplasms, Triple Negative Breast Neoplasms

NCT02851706 2026-03-27

Natural History of and Specimen Banking for People With Tumors of the Central Nervous System

Astrocytoma, Brain Neoplasms, Glioma, Neoplasms, Spinal Cord Neoplasms

NCT05413304 2026-03-24

Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis

Phase 1 Active not recruiting

Brain Neoplasms, Glioma

NCT04301089 2026-03-11

Immersive Virtual Reality (VR) at the Time of Clinical Evaluation to Improve Psychological Distress and Anxiety in Primary Brain Tumor (PBT) Patients

Phase 2 Completed

61 enrolled 20 charts

Anxiety Disorders, Brain Neoplasms

NCT02942264 2026-02-23

Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma

Phase 1/2 Terminated

53 enrolled 22 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Recurrence, Gliosarcoma

NCT02709226 2025-12-31

Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

Phase 1 Completed

Astrocytoma, Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT04631029 2025-10-03

Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread

Phase 1 Completed

3 enrolled 12 charts

Brain Neoplasms

NCT01931098 2025-08-11

Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab

Phase 2 Completed

35 enrolled 13 charts

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT01295944 2025-08-05

Carboplatin and Bevacizumab for Recurrent Ependymoma

Phase 2 Completed

35 enrolled 17 charts

Brain Neoplasms, Ependymoma, Neoplasms, Neurologic Manifestations, Spinal Cord Neoplasms

NCT03173950 2025-06-29

Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers

Phase 2 Completed

Brain Neoplasms, Ependymoma, Medulloblastoma, Meningioma, Pinealoma, Spinal Cord Neoplasms, Choroid Plexus Neoplasms