Announcements Trials
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Phase

Phase 2 2Phase 1/2 2Phase 1 1

Status

Active not recruiting 3Recruiting 2

Sponsor Class

INDUSTRY 3OTHER 1NIH 1

Study Type

Interventional 5

Sponsor

Cancer Type

CNS 5Thoracic 1Breast 1

Conditions

Breast Neoplasms 29Neoplasms 8Neoplasm Metastasis 8Brain Neoplasms 5Prostatic Neoplasms 4Ovarian Neoplasms 4Glioma 4Endometrial Neoplasms 4Triple Negative Breast Neoplasms 3Neoplasms by Site 3Breast Diseases 3Squamous Cell Carcinoma of Head and Neck 2Recurrence 2Meningioma 2Head and Neck Neoplasms 2Glioblastoma 2Uterine Cervical Neoplasms 1Unilateral Breast Neoplasms 1Spinal Cord Neoplasms 1Small Cell Lung Carcinoma 1Sarcoma, Kaposi 1Sarcoma, Ewing 1Sarcoma 1Recurrent Ovarian High Grade Serous Adenocarcinoma 1Pathologic Complete Response 1Pancreatic Neoplasms 1Neurofibromatosis 1 1Neoplasms, Squamous Cell 1Neoplasm, Residual 1Multiple Myeloma 1

Interventions

Radiosurgery 31Magnetic Resonance Spectroscopy 16Temozolomide 12pembrolizumab 11Nivolumab 10Specimen Handling 8Ipilimumab 8Bevacizumab 8Radiotherapy 7Mental Status and Dementia Tests 7Memantine 7abemaciclib 5Blood Specimen Collection 5Biopsy 4trastuzumab deruxtecan 3entrectinib 3Surveys and Questionnaires 3Surgical Procedures, Operative 3Sodium Chloride 3Saline Solution 3Receptors, Interleukin-8B 3Proton Therapy 3Dexamethasone 3Cyclophosphamide 3trametinib 2pertuzumab 2osimertinib 2fluciclovine F-18 2contrast agent BR1 2atezolizumab 2

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Brain Neoplasms × abemaciclib × 90 days × Clear all
NCT06413706 2026-05-22

A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy

Eli Lilly and Company

Phase 2 Active not recruiting
45 enrolled
CNS

Brain Neoplasms, Glioma, Neoplasms, Spinal Cord Neoplasms

NCT03994796 2026-04-13

Genetic Testing in Guiding Treatment for Patients With Brain Metastases

Alliance for Clinical Trials in Oncology

Phase 2 Active not recruiting
50 enrolled
CNS

Brain Neoplasms, Neoplasm Metastasis

NCT06810544 2026-04-13

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

Tango Therapeutics, Inc.

Phase 1/2 Recruiting
191 enrolled
CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioblastoma, Glioma, Lung Neoplasms

NCT05386108 2026-04-06

ELECTRA

Stemline Therapeutics, Inc.

Phase 1/2 Recruiting
73 enrolled
BreastCNS

Brain Diseases, Brain Neoplasms, Breast Diseases, Breast Neoplasms, Central Nervous System Diseases, Neoplasms, Neoplasms by Site, Central Nervous System Neoplasms

NCT05413304 2026-03-24

Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis

National Institutes of Health Clinical Center (CC)

Phase 1 Active not recruiting
1 enrolled
CNS

Brain Neoplasms, Glioma

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