Clinical Trials

60 enrolled 19 charts

Brain Neoplasms

NCT02858869 2026-03-09

Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases

25 enrolled 14 charts

CNSDermatologicThoracic

Uveal Melanoma, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT02993146 2025-10-29

Ropidoxuridine and Whole Brain Radiation Therapy in Treating Patients With Brain Metastases

CNSOther hematologic neoplasm

11 enrolled 12 charts

Brain Neoplasms, Hematologic Neoplasms

NCT04543188 2025-10-23

A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement

65 enrolled 52 charts

CNSDermatologicThoracic

Brain Diseases, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasms, Central Nervous System Neoplasms

NCT02589522 2025-10-08

Testing the Safety of M6620 (VX-970) When Given With Standard Whole Brain Radiation Therapy for the Treatment of Brain Metastases From Non-small Cell Lung Cancer, Small Cell Lung Cancer, or Neuroendocrine Tumors

15 enrolled 10 charts

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Small Cell Lung Carcinoma

NCT03426891 2025-10-06

Pembrolizumab and Vorinostat Combined With Temozolomide for Newly Diagnosed Glioblastoma

21 enrolled 12 charts

Brain Neoplasms, Glioblastoma

NCT04631029 2025-10-03

Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread

3 enrolled 12 charts

Brain Neoplasms

NCT02062827 2025-10-02

M032-HSV-1

29 enrolled 16 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Virus Diseases, Gliosarcoma

NCT03657576 2025-08-03

C134-HSV-1

19 enrolled 12 charts

Brain Neoplasms, Glioblastoma, Glioma

NCT03128047 2025-07-08

HUMC 1612: Optune NovoTTF-200A System

7 enrolled 12 charts

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Neoplasms

NCT04460937 2025-07-08

Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers

4 enrolled 9 charts

CNSGastrointestinal

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Brain Neoplasms, Meningeal Carcinomatosis

NCT00308165 2025-06-27

Topotecan by Intracerebral Clysis for Recurrent Primary Malignant Brain Tumors

16 enrolled 14 charts

Brain Neoplasms

NCT01703507 2025-05-16

Phase I Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma

17 enrolled 15 charts

CNSDermatologic

Brain Neoplasms, Melanoma

NCT00838929 2025-05-04

Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases

17 enrolled 8 charts

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms

NCT02186509 2025-04-30

Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas

17 enrolled 11 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT02323880 2025-01-14

Selinexor in Treating Younger Patients With Recurrent or Refractory Solid Tumors or High-Grade Gliomas

59 enrolled 20 charts

CNSLymphoid

Astrocytoma, Brain Neoplasms, Glioma, Lymphoma, Central Nervous System Neoplasms

NCT03087591 2024-10-10

APN401 in Treating Patients With Recurrent or Metastatic Pancreatic Cancer, Colorectal Cancer, or Other Solid Tumors That Cannot Be Removed by Surgery

11 enrolled 26 charts

CNSGastrointestinal

Brain Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Colorectal Neoplasms

NCT03328143 2024-10-03

Feasibility of Aromatherapy in an Awake Craniotomy Environment

40 enrolled 8 charts

Anxiety Disorders, Brain Neoplasms, Neoplasms

NCT03493932 2024-07-24

Cytokine Microdialysis for Real-Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade

21 enrolled 9 charts

Brain Neoplasms, Glioblastoma, Glioma

NCT03250299 2024-06-24

Microtubule-Targeted Agent BAL101553 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

26 enrolled 17 charts

Brain Neoplasms, Glioblastoma

NCT03705351 2024-03-04

Tumor Treating Fields With Chemoradiation in Newly Diagnosed GBM

7 enrolled 12 charts

Brain Neoplasms, Glioblastoma

NCT02193347 2023-12-01

RESIST

24 enrolled 8 charts

Brain Neoplasms, Recurrence

NCT01491893 2023-09-28

PVSRIPO

61 enrolled 10 charts

Brain Neoplasms, Glioblastoma, Glioma

NCT03072134 2023-01-20

Neural Stem Cell Based Virotherapy of Newly Diagnosed Malignant Glioma

12 enrolled 13 charts

Adenoviridae Infections, Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma

NCT03332589 2022-05-20

E6201 Plus Dabrafenib for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS)

4 enrolled 9 charts

CNSDermatologic

Brain Neoplasms, Melanoma

NCT02015819 2021-10-20

Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas

16 enrolled 16 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT00707343 2021-10-15

[F-18] Fluorothymidine (FLT) Imaging on Patients With Primary Brain Tumors

15 enrolled 3 charts

Brain Neoplasms, Neoplasms

NCT01951950 2014-08-29

Nicardipine vs Esmolol Craniotomy Emergence

40 enrolled 6 charts

Brain Neoplasms

NCT00314808 2014-07-16

A Pilot Study of Dronabinol for Adult Patients With Primary Gliomas

33 enrolled 9 charts

Brain Neoplasms, Nausea, Vomiting

NCT00470847 2014-05-22

Lapatinib in Combination With Radiation Therapy in Patients With Brain Metastases From HER2-Positive Breast Cancer