Clinical Trials

296 enrolled 11 charts

Brain Neoplasms

NCT06057168 2026-01-29

GDX-44-016

138 enrolled 7 charts

Brain Neoplasms

NCT03873818 2026-01-09

Low Dose Ipilimumab With Pembrolizumab in Treating Patients With Melanoma That Has Spread to the Brain

24 enrolled 13 charts

CNSDermatologic

Brain Neoplasms, Melanoma

NCT03412812 2025-11-04

RAD1705

13 enrolled 9 charts

Brain Neoplasms

NCT03076255 2025-10-15

Using a Head and Neck Maskless Immobilization Device For Patients With Intracranial Tumors

12 enrolled 7 charts

CNSHead & Neck

Brain Neoplasms, Head and Neck Neoplasms, Neurologic Manifestations

NCT02285439 2025-10-07

Study of MEK162 for Children With Low-Grade Gliomas

Phase 1/2 Completed

105 enrolled 17 charts

Brain Neoplasms, Soft Tissue Neoplasms

NCT03426891 2025-10-06

Pembrolizumab and Vorinostat Combined With Temozolomide for Newly Diagnosed Glioblastoma

21 enrolled 12 charts

Brain Neoplasms, Glioblastoma

NCT04631029 2025-10-03

Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread

3 enrolled 12 charts

Brain Neoplasms

NCT04410133 2025-08-28

REVELATE

151 enrolled 29 charts

Brain Neoplasms, Disease

NCT01063114 2025-08-13

Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma

90 enrolled 11 charts

Brain Neoplasms, Medulloblastoma, Pinealoma

NCT01931098 2025-08-11

Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab

35 enrolled 13 charts

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT02681549 2025-08-07

Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer (NSCLC)

41 enrolled 20 charts

CNSDermatologicThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT01295944 2025-08-05

Carboplatin and Bevacizumab for Recurrent Ependymoma

35 enrolled 17 charts

Brain Neoplasms, Ependymoma, Neoplasms, Neurologic Manifestations, Spinal Cord Neoplasms

NCT04410367 2025-07-20

PURSUE

23 enrolled 10 charts

Brain Neoplasms, Disease

NCT02986178 2025-07-11

Lerapolturev in Recurrent Malignant Glioma

121 enrolled 15 charts

Brain Neoplasms, Glioblastoma, Glioma, Recurrence

NCT03128047 2025-07-08

HUMC 1612: Optune NovoTTF-200A System

7 enrolled 12 charts

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Neoplasms

NCT00308165 2025-06-27

Topotecan by Intracerebral Clysis for Recurrent Primary Malignant Brain Tumors

16 enrolled 14 charts

Brain Neoplasms

NCT02514915 2025-06-26

Pre-operative Stereotactic Radiosurgery Followed by Resection for Brain Metastases

24 enrolled 21 charts

Brain Neoplasms

NCT04420598 2025-06-24

DEBBRAH

41 enrolled 32 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Meningeal Carcinomatosis

NCT02667587 2025-06-18

CheckMate548

716 enrolled 15 charts

Brain Neoplasms

NCT04479241 2025-06-05

LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients With Recurrent Glioblastoma

25 enrolled 12 charts

Brain Neoplasms, Glioblastoma

NCT01288235 2025-06-03

Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation

100 enrolled 11 charts

Phase EARLY_PHASE1 Completed

Astrocytoma, Brain Neoplasms, Ependymoma, Ganglioglioma

NCT03834740 2025-05-30

A Phase 0/I Study of Ribociclib (LEE011) in Combination With Everolimus in Preoperative Recurrent High-Grade Glioma Patients Scheduled for Resection

27 enrolled 17 charts

Brain Neoplasms, Glioblastoma, Glioma

NCT03898908 2025-05-21

EBRAIN-MEL

48 enrolled 24 charts

CNSDermatologic

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT01703507 2025-05-16

Phase I Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma

17 enrolled 15 charts

CNSDermatologic

Brain Neoplasms, Melanoma

NCT00838929 2025-05-04

Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases

17 enrolled 8 charts

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms

NCT02186509 2025-04-30

Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas

17 enrolled 11 charts

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT02392078 2025-04-24

LAANTERN

Completed

1,153 enrolled 15 charts

Brain Neoplasms, Epilepsy, Movement Disorders, Disease Progression

NCT02360215 2025-04-23

Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases

518 enrolled 40 charts

Brain Neoplasms, Cognitive Dysfunction

NCT03632135 2025-04-15

CSCRGBM

78 enrolled 10 charts

Brain Neoplasms, Glioblastoma

NCT05087095 2025-04-09

Managing Distress in Malignant Brain Cancer

13 enrolled 11 charts

Brain Neoplasms

NCT01604512 2025-04-08

A Comparison of MRI Perfusion and FDG PET/CT to Distinguish Between Radiation Injury and Tumor Progression

148 enrolled 9 charts

Brain Neoplasms

NCT01894061 2025-02-17

NovoTTF-100A With Bevacizumab (Avastin) in Patients With Recurrent Glioblastoma

25 enrolled 16 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT03150862 2025-02-04

A Study Assessing Pamiparib With Radiation and/or Temozolomide (TMZ) in Participants With Newly Diagnosed or Recurrent Glioblastoma

Phase 1/2 Completed

116 enrolled 31 charts