Clinical Trials

90 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT04804644 2026-04-03

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

Phase 3 Recruiting

200 enrolled

Brain Neoplasms, Lung Neoplasms, Small Cell Lung Carcinoma

NCT06474533 2026-04-03

Fluoroethyltyrosine for the Evaluation of Intracranial Neoplasm

Recruiting

199 enrolled

BreastCNSDermatologicGenitourinaryThoracic

Brain Neoplasms

NCT06500455 2026-04-03

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

Phase 3 Recruiting

269 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Lung Neoplasms, Melanoma, Neoplasm Metastasis

NCT05977803 2026-03-31

ACROP

60 enrolled

Phase 2 Active not recruiting

Brain Neoplasms, Lung Neoplasms, Neoplasm Metastasis

NCT02971501 2026-03-17

Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases

7 enrolled 9 charts

Phase 2 Not yet recruiting

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT06667726 2026-03-16

An Investigational Scan (18F-DOPA PET/CT) for Improving the Clinical Management of Brain Tumors

47 enrolled

Brain Neoplasms

NCT04044937 2026-03-11

UC-GlioFET

Phase 2 Completed

143 enrolled

Brain Neoplasms, Glioblastoma

NCT06914479 2026-03-11

Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors

11 enrolled

Brain Neoplasms

NCT06315296 2026-03-03

An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer

Phase NA Terminated

1 enrolled

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms

NCT06322602 2026-03-03

Ommaya Reservoir Placement at the Time of Biopsy for Longitudinal Biomarker Collection in Patients With Brain Tumors

20 enrolled

Brain Neoplasms

NCT03270059 2026-02-27

Gadolinium and Ferumoxytol MRI in Diagnosing Patients With Abnormalities in the Central Nervous System

150 enrolled

Brain Neoplasms, Cranial Nerve Diseases, Central Nervous System Neoplasms

NCT05376878 2026-02-23

An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis

Phase 4 Recruiting

Phase NA Not yet recruiting

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT07278440 2026-02-13

An Exercise Intervention for Improving Mental and Physical Health in Patients With Primary Brain Tumors and Their Caregivers, ET-NEURO Trial

36 enrolled

Brain Neoplasms

NCT04047264 2026-02-12

Feasibility of Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

100 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT06132685 2026-02-10

Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial

200 enrolled

Phase 1 Active not recruiting

Brain Neoplasms, Meningioma

NCT04459273 2026-02-05

FAPI PET RDRC

26 enrolled

CNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETOther hematologic neoplasm

Adrenal Gland Neoplasms, Urinary Bladder Neoplasms, Brain Neoplasms, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Neoplasms, Unknown Primary, Skin Neoplasms, Testicular Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Cholangiocarcinoma, Neuroendocrine Tumors, Hematologic Neoplasms

NCT06650163 2026-02-05

Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors

20 enrolled

Brain Neoplasms, Glioma, Meningioma

NCT07339085 2026-01-15

Advanced Magnetic Resonance Imaging for the Identification of Recurrent Brain Tumors and Radiation Necrosis

42 enrolled

Brain Neoplasms

NCT03830151 2026-01-13

Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors

13 enrolled

Brain Neoplasms

NCT06788886 2025-12-30

Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases

CNSEndocrineGenitourinaryNET

147 enrolled

Brain Neoplasms, Multiple Sclerosis, Prostatic Neoplasms, Neuroendocrine Tumors

NCT03750227 2025-12-24

Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

Phase 3 Recruiting

140 enrolled

Brain Neoplasms

NCT05904704 2025-11-14

Oxygen-Enhanced MRI for Generating Hypoxia Maps in Patients With Intracranial Tumors

Phase NA Withdrawn

Brain Neoplasms

NCT00870129 2025-10-10

Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors

135 enrolled

Phase EARLY_PHASE1 Recruiting

Brain Neoplasms, Glioma

NCT06328686 2025-09-17

Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases

Brain Neoplasms, Neoplasm Metastasis

NCT04462419 2025-09-10

18F-fluciclovine PET/MRI Imaging for the Detection of Tumor Recurrence After Radiation Injury to the Brain

Terminated

19 enrolled

Brain Neoplasms

NCT05388877 2025-08-19

E6201 and Dabrafenib for the Treatment of Central Nervous System Metastases From BRAF V600 Mutated Metastatic Melanoma

Phase 1 Terminated

13 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT07118176 2025-08-12

Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers

BreastCNSEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETSarcomaThoracic

30 enrolled

Adrenal Gland Neoplasms, Anus Neoplasms, Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Penile Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Colorectal Neoplasms, Carcinoma, Medullary, Cholangiocarcinoma, Neuroendocrine Tumors, Solitary Fibrous Tumors

NCT04588246 2025-06-06

Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery

Phase 3 Terminated

19 enrolled 19 charts

BreastCNSDermatologicGastrointestinalGenitourinaryThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Small Cell Lung Carcinoma

NCT05840770 2025-05-26

Cemiplimab for the Treatment of Untreated Brain Metastases From PD-L1 >= 50% Non-Small Cell Lung Cancer

Phase 2 Withdrawn

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT03649880 2025-03-25

Feasibility of FMISO in Brain Tumors

50 enrolled

Phase EARLY_PHASE1 Completed

Brain Neoplasms

NCT02020720 2025-01-23

18F-DOPA-PET in Planning Surgery in Patients With Gliomas

72 enrolled

Phase EARLY_PHASE1 Recruiting

Brain Neoplasms, Glioma

NCT05996432 2024-09-23

Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy

48 enrolled

CNSHead & Neck

Squamous Cell Carcinoma of Head and Neck, Brain Neoplasms

NCT03539731 2024-08-12

[18F]DASA-23 and PET Scan in Evaluating Pyruvate Kinase M2 Expression in Patients With Intracranial Tumors or Recurrent Glioblastoma and Healthy Volunteers

Phase 1 Terminated

27 enrolled

Phase NA Not yet recruiting

Brain Neoplasms, Glioblastoma

NCT06466031 2024-07-30

Application of MET-PET in Fusion With MRI in the Treatment of Glioblastoma Multiforme

189 enrolled

Phase EARLY_PHASE1 Completed

Brain Neoplasms, Glioblastoma

NCT04752267 2024-05-24

18F-FMAU PET/CT and MRI for the Detection of Brain Tumors in Patients With Brain Cancer or Brain Metastases

BreastCNSDermatologicGastrointestinalGenitourinaryThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Colonic Neoplasms, Glioma, Lung Neoplasms, Melanoma

NCT05054998 2024-05-01

Dual Time Point FDG PET/MRI Scan in Improving the Imaging Cancer Patients With Brain Metastases

Phase 4 Completed

12 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT06137651 2024-04-01

Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis

Phase 1 Withdrawn

BreastCNS

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT06257498 2024-02-14

Heads-Up

9 enrolled

Brain Neoplasms

NCT02073968 2024-01-25

PAINT

Phase 2 Completed

35 enrolled 13 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT03680144 2024-01-11

Utility of Perfusion MRI to Detect Radiation Necrosis in Patients With Brain Metastases

8 enrolled

Brain Neoplasms

NCT04132843 2022-11-21

Novel MRI Techniques for the Characterization and Treatment Assessment of High Grade Brain Lesions

6 enrolled

CNSLymphoid

Brain Neoplasms, Lymphoma

NCT04501731 2022-05-25

5C-pilot

Unknown

Brain Neoplasms

NCT02843230 2022-04-08

Monitoring Anti-angiogenic Therapy in Brain Tumors by Advanced MRI

Completed

30 enrolled

Brain Neoplasms, Glioblastoma

NCT03234309 2021-11-10

Ferumoxytol in Magnetic Resonance Imaging of Pediatric Patients With Brain Tumors

Phase 2 Withdrawn

Brain Neoplasms

NCT00597246 2020-12-17

Imaging Brain Tumors With FACBC and Methionine

30 enrolled 7 charts

Brain Neoplasms, Central Nervous System Neoplasms

NCT01674582 2020-09-03

Treatment Effects Inclusive Cognitive Impact and Possibilities to Individually Adjusted Treatment in Patients With Intracranial Tumors With Clinical, Neuropsychological and Imaging Parameters

150 enrolled

Brain Neoplasms, Glioma

NCT01228448 2020-08-18

In-Room PET in Proton Radiation Therapy