Clinical Trials

BreastCNSGastrointestinalGenitourinaryHead & NeckThoracic

Brain Neoplasms

NCT04075305 2026-03-05

MOMENTUM

Recruiting

8,000 enrolled

Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Esophageal Neoplasms, Genital Neoplasms, Female, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Radiation Injuries, Rectal Neoplasms

NCT07448493 2026-03-04

GASTROBRAIN

Active not recruiting

230 enrolled

CNSGastrointestinal

Brain Neoplasms, Esophageal Neoplasms, Stomach Neoplasms

NCT07448662 2026-03-04

COLBRAIN

Active not recruiting

700 enrolled

CNSGastrointestinal

Brain Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT05124912 2026-02-20

REMASTer: REcurrent Brain Metastases After SRS Trial

Phase NA Recruiting

261 enrolled

Brain Neoplasms, Neoplasm Metastasis, Recurrence

NCT05535166 2026-02-12

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

Phase 2 Recruiting

130 enrolled

Phase NA Active not recruiting

Brain Neoplasms, Medulloblastoma

NCT02698254 2026-01-07

Radiation Therapy in Treating Patients With Recurrent Brain Tumors Who Have Undergone Previous Radiation Therapy

40 enrolled

Brain Neoplasms

NCT06991101 2025-12-26

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

Phase 2 Recruiting

190 enrolled

Brain Neoplasms, Glioblastoma

NCT03423628 2025-12-22

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Phase 1 Recruiting

180 enrolled

Phase 2/3 Active not recruiting

Brain Neoplasms, Glioblastoma, Inhibition, Psychological, Meningeal Neoplasms, Hereditary Sensory and Autonomic Neuropathies

NCT02066220 2025-12-04

International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma

360 enrolled

Phase 2 Active not recruiting

Brain Neoplasms, Medulloblastoma, Neuroectodermal Tumors, Primitive

NCT01878617 2025-11-13

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

660 enrolled

Phase 2 Active not recruiting

Brain Neoplasms, Medulloblastoma, Infratentorial Neoplasms, Neuroectodermal Tumors, Primitive

NCT02792582 2025-11-12

A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection

160 enrolled

Brain Neoplasms, Craniopharyngioma

NCT03426891 2025-10-06

Pembrolizumab and Vorinostat Combined With Temozolomide for Newly Diagnosed Glioblastoma

21 enrolled 12 charts

Phase 1/2 Not yet recruiting

Brain Neoplasms, Glioblastoma

NCT07177950 2025-09-17

A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases

51 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT04460937 2025-07-08

Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers

Phase 1 Active not recruiting

4 enrolled 9 charts

CNSGastrointestinal

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Brain Neoplasms, Meningeal Carcinomatosis

NCT04121455 2025-06-25

GLORIA

Phase 1/2 Active not recruiting

117 enrolled

Phase EARLY_PHASE1 Completed

Brain Neoplasms, Glioblastoma

NCT02970448 2025-06-19

Expedited Laser Interstitial Thermal Therapy + Chemoradiation For Newly Diagnosed High Grade Gliomas

13 enrolled

Brain Neoplasms, Glioma

NCT02667587 2025-06-18

CheckMate548

716 enrolled 15 charts

Brain Neoplasms

NCT00838929 2025-05-04

Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases

17 enrolled 8 charts

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms

NCT00639262 2025-05-02

Combination of Sorafenib and Radiation for Brain Metastases and Primary Brain Tumors

35 enrolled

Phase 3 Not yet recruiting

Brain Neoplasms

NCT06477939 2024-06-27

THREE-GLEES

554 enrolled

Hypoxia, Brain Neoplasms, Glioblastoma

NCT03250299 2024-06-24

Microtubule-Targeted Agent BAL101553 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Phase 1 Terminated

26 enrolled 17 charts

Phase 2 Not yet recruiting

Brain Neoplasms, Glioblastoma

NCT06462079 2024-06-17

Sacituzumab Govitecan Combined With Head Radiotherapy for Her2-negative Breast Cancer Brain Metastases

43 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT00884598 2024-05-10

CIRAB

19 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Central Nervous System Neoplasms

NCT06137651 2024-04-01

Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis

Phase 1 Withdrawn

BreastCNS

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT03705351 2024-03-04

Tumor Treating Fields With Chemoradiation in Newly Diagnosed GBM

Phase 1 Terminated

7 enrolled 12 charts

Brain Neoplasms, Glioblastoma

NCT01854554 2024-01-02

Glioblastoma Multiforme (GBM) Proton vs. Intensity Modulated Radiotherapy (IMRT)

90 enrolled 11 charts

Brain Neoplasms, Glioblastoma

NCT00895622 2023-09-08

Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma

244 enrolled 15 charts

Brain Neoplasms, Meningioma, Central Nervous System Neoplasms

NCT00080938 2023-06-29

Temozolomide and Radiation Therapy in Treating Patients With Brain Metastasis Secondary to Non-Small Cell Lung Cancer

26 enrolled 8 charts

CNSThoracic

Adenocarcinoma of Lung, Brain Neoplasms, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT00187226 2023-05-31

A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects

361 enrolled 11 charts

Brain Neoplasms, Central Nervous System Neoplasms

NCT02617589 2023-03-28

CheckMate 498

560 enrolled 14 charts

Brain Neoplasms

NCT03696355 2023-01-18

Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas

27 enrolled

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms

NCT01730950 2022-12-29

Bevacizumab With or Without Radiation Therapy in Treating Patients With Recurrent Glioblastoma

182 enrolled 19 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT05616377 2022-11-15

CLTBME

Unknown

2,000 enrolled

Brain Neoplasms

NCT01469247 2022-10-20

Diffuse Intrinsic Pontine Glioma (DIPG) Reirradiation (ReRT)

Phase 1/2 Completed

12 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Recurrence

NCT00377156 2022-09-16

Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases

BreastCNSGenitourinaryThoracic

213 enrolled 16 charts

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis, Prostatic Neoplasms, Breast Neoplasms, Male

NCT05477316 2022-07-28

A Study to Assess the Efficacy of Cerebellar IMRT Combined With Cerebral SRS in Patients With Brain Metastases

Phase NA Unknown

37 enrolled

Brain Neoplasms

NCT00871923 2021-09-16

Tarceva With Whole Brain Radiation Therapy - Brain Mets From Non-Small Cell Lung Cancer

44 enrolled 16 charts

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00031798 2021-09-09

Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors

Phase 3 Terminated

Astrocytoma, Brain Neoplasms, Depression, Ependymoma, Fatigue, Glioblastoma, Glioma, Meningioma, Oligodendroglioma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Gliosarcoma

NCT00049361 2021-09-09

Radiation Therapy Plus Thalidomide and Temozolomide in Treating Patients With Newly Diagnosed Brain Metastases

Brain Neoplasms, Central Nervous System Neoplasms

NCT00005887 2021-08-23

Radiation Therapy With or Without RSR13 in Treating Patients With Brain Metastases

Brain Neoplasms, Neoplasm Metastasis

NCT00879437 2021-07-21

Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma

38 enrolled 53 charts

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neuroepithelial, Gliosarcoma

NCT02046187 2021-06-16

Ketogenic Diet With Radiation and Chemotherapy for Newly Diagnosed Glioblastoma

Phase 1/2 Terminated

14 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT02903069 2021-04-19

Study of Marizomib With Temozolomide and Radiotherapy in Patients With Newly Diagnosed Brain Cancer

66 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT03394716 2021-04-19

Monitoring MRI Changes Before and During Radiotherapy Treatment of Brain Tumors

Terminated

45 enrolled

Brain Neoplasms

NCT01414738 2021-01-26

Hippocampal-Avoiding Whole Brain Irradiation With Simultaneous Integrated Boost for Treatment of Brain Metastases

50 enrolled 20 charts

Brain Neoplasms

NCT01740258 2021-01-26

BBP

68 enrolled 11 charts

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00033254 2020-10-30

Radiation Therapy With or Without Thalidomide in Treating Patients With Brain Metastases

332 enrolled

Brain Neoplasms

NCT00031967 2020-10-22

Melatonin and Radiation Therapy in Treating Patients With Brain Metastases