Clinical Trials Browser

Recruiting × Brain Neoplasms × Temozolomide × Clear all

Brain Neoplasms

NCT07326566 2026-04-14

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

Phase 2 Recruiting

162 enrolled

CNS

Brain Neoplasms, Central Nervous System Diseases, Glioblastoma, Glioma

NCT06012695 2026-04-13

NBM-BMX Administered Orally to Patients With Solid Tumors or Newly Diagnosed Glioblastoma

Phase 1/2 Recruiting

79 enrolled

CNS

Brain Neoplasms, Neoplasms

NCT06388733 2026-04-01

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

Phase 3 Recruiting

450 enrolled

CNS

Brain Neoplasms, Glioblastoma

NCT05843253 2026-03-20

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

Phase 2 Recruiting

120 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT07297212 2026-03-12

A Clinical Trial Testing the Safety of the Investigational Drug Pumitamig (BNT327) and How Well it Works in Patients With Recurrent Glioblastoma

Phase 2 Recruiting

75 enrolled

CNS

Brain Neoplasms, Glioblastoma

NCT05629702 2026-01-30

ARISTOCRAT

Phase 2 Recruiting

120 enrolled

CNS

Brain Neoplasms, Marijuana Abuse, Glioblastoma, Recurrence

NCT05588453 2026-01-12

Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain

Phase 1/2 Recruiting

30 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT05106296 2026-01-09

Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer

Phase 1 Recruiting

37 enrolled

CNS

Brain Neoplasms, Ependymoma, Glioblastoma, Medulloblastoma, Neuroectodermal Tumors, Primitive

NCT06991101 2025-12-26

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

Phase 2 Recruiting

190 enrolled

CNS

Brain Neoplasms, Glioblastoma

NCT03213002 2025-04-09

CAPTEM

Phase 1/2 Recruiting

67 enrolled

CNS

Brain Neoplasms, Glioblastoma, Neoplasms

NCT06161974 2025-02-21

Study of Olutasidenib and Temozolomide in HGG

Phase 2 Recruiting

60 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Spinal Cord Neoplasms

NCT05271240 2024-09-19

Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM

Phase 3 Recruiting

432 enrolled

CNS

Brain Neoplasms, Glioblastoma, Glioma

Clinical Trials

Study of Letrozole in Recurrent Gliomas

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

NBM-BMX Administered Orally to Patients With Solid Tumors or Newly Diagnosed Glioblastoma

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

A Clinical Trial Testing the Safety of the Investigational Drug Pumitamig (BNT327) and How Well it Works in Patients With Recurrent Glioblastoma

ARISTOCRAT

Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain

Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

CAPTEM

Study of Olutasidenib and Temozolomide in HGG

Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM