Announcements Trials
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Phase

Phase 2 4Phase 1/2 2Phase 1 1

Status

Active not recruiting 2Withdrawn 1Unknown 1Terminated 1Recruiting 1Completed 1

Sponsor Class

OTHER 5INDUSTRY 2

Study Type

Interventional 7Expanded_access 1

Sponsor

Cancer Type

CNS 7Breast 3

Conditions

Breast Neoplasms 32Colorectal Neoplasms 8Brain Neoplasms 7Stomach Neoplasms 4Neoplasms 4Neoplasm Metastasis 4Carcinoma, Non-Small-Cell Lung 4Triple Negative Breast Neoplasms 3Meningeal Neoplasms 3HER2-positive Breast Cancer 3Rectal Neoplasms 2Multiple Myeloma 2Lymphoma, Non-Hodgkin 2Colonic Neoplasms 2Adenocarcinoma Of Esophagus 2Uterine Neoplasms 1Uterine Cervical Neoplasms 1Urologic Neoplasms 1Pathologic Complete Response 1Ovarian Neoplasms 1Metastatic Breast Cancer With a Isolated Brain Progression 1Meningeal Carcinomatosis 1Lung Neoplasms 1Hemangiosarcoma 1HER2-positive Metastatic Breast Cancer 1HER2-positive Gastric Cancer 1Gallbladder Neoplasms 1Esophageal Neoplasms 1Cholangiocarcinoma 1Central Nervous System Diseases 1

Interventions

Temozolomide 162Radiosurgery 114Radiotherapy 99Bevacizumab 95Magnetic Resonance Spectroscopy 64Carboplatin 48Etoposide 34Surgical Procedures, Operative 33Irinotecan 33pembrolizumab 32Nivolumab 32Cyclophosphamide 32Erlotinib Hydrochloride 31Radiation 29Carmustine 28Cisplatin 25Lomustine 24Trastuzumab 23Ipilimumab 23Filgrastim 23Vincristine 20Mental Status and Dementia Tests 20Aminolevulinic Acid 19Topotecan 18Pemetrexed 18Capecitabine 18Specimen Handling 17Sorafenib 15Radiotherapy, Intensity-Modulated 15Imatinib Mesylate 15

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

7 trials
RecentStart dateEnrollment
Interventional × Brain Neoplasms × tucatinib × Clear all
NCT05323955 2026-03-17

BRIDGET

Duke University

Phase 2 Active not recruiting
48 enrolled
CNS

Brain Neoplasms

NCT05673928 2026-01-21

A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)

M.D. Anderson Cancer Center

Phase 2 Recruiting
30 enrolled
CNS

Brain Neoplasms, Neoplasm Metastasis

NCT05553522 2025-12-31

Tucatinib, Trastuzumab, and Capecitabine With SRS for Brain Metastases From HER-2 Positive Breast Cancer

Baptist Health South Florida

Phase 1 Terminated
1 enrolled
CNS

Brain Neoplasms

NCT04538742 2025-12-08

DB-07

AstraZeneca

Phase 1/2 Active not recruiting
245 enrolled
BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT02614794 2023-08-14

HER2CLIMB

Seagen Inc.

Phase 2 Completed
612 enrolled 30 charts 1 FDA
BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT04512261 2022-07-01

TOPAZ

Cedars-Sinai Medical Center

Phase 1/2 Withdrawn
BreastCNS

Brain Neoplasms, Breast Neoplasms, Central Nervous System Diseases

NCT04760431 2021-06-02

TKIs vs. Pertuzumab in HER2+ Breast Cancer Patients With Active Brain Metastases (HER2BRAIN)

Second Affiliated Hospital, School of Medicine, Zhejiang University

Phase 2 Unknown
120 enrolled
CNS

Brain Neoplasms

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