Clinical Trials

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Recurrence

NCT05588141 2026-05-01

A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

Phase 1/2 Recruiting

96 enrolled

Brain Neoplasms, Glioma, Neoplasms, Recurrence

NCT02942264 2026-02-23

Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma

53 enrolled 22 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Recurrence, Gliosarcoma

NCT01217411 2024-11-19

RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer

BreastCNSDermatologicThoracic

5 enrolled 6 charts

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Breast Neoplasms, Male, Small Cell Lung Carcinoma

NCT03190967 2023-10-11

T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery

12 enrolled 16 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT03803761 2023-09-25

A Study of a New Drug Combination, Copanlisib and Fulvestrant, in Advanced Breast Cancer

Phase 1/2 Withdrawn

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT01434602 2022-06-01

Phase I-II Everolimus and Sorafenib in Recurrent High-Grade Gliomas

86 enrolled 24 charts

Brain Neoplasms, Glioblastoma

NCT01051557 2021-07-19

Temsirolimus and Perifosine in Treating Patients With Recurrent or Progressive Malignant Glioma

36 enrolled 15 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT01454596 2019-08-21

CAR T Cell Receptor Immunotherapy Targeting EGFRvIII for Patients With Malignant Gliomas Expressing EGFRvIII

18 enrolled 25 charts

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00329719 2018-10-16

Sorafenib Tosylate and Temsirolimus in Treating Patients With Recurrent Glioblastoma

115 enrolled 13 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00335764 2018-07-02

Sorafenib Combined With Erlotinib, Tipifarnib, or Temsirolimus in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma

92 enrolled 24 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT01648348 2018-05-23

Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme

116 enrolled 17 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00045708 2017-10-18

A Phase I/II Trial of BMS-247550 for Treatment of Patients With Recurrent High-Grade Gliomas

57 enrolled 18 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00045110 2017-08-17

Erlotinib in Treating Patients With Recurrent Malignant Glioma or Recurrent or Progressive Meningioma

136 enrolled 27 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Meningioma, Oligodendroglioma, Gliosarcoma

NCT00379080 2017-04-07

Tandutinib in Treating Patients With Recurrent or Progressive Glioblastoma

60 enrolled 22 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00085540 2017-01-02

FR901228 in Treating Patients With Recurrent High-Grade Gliomas

50 enrolled 6 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT01189240 2015-12-14

RO4929097and Bevacizumab in Treating Patients With Progressive or Recurrent Malignant Glioma

13 enrolled 13 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT00112736 2015-06-15

Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma

69 enrolled 12 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00099060 2014-01-27

Lapatinib in Treating Patients With Recurrent Glioblastoma Multiforme

24 enrolled

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00107367 2014-01-10

Radiation Therapy in Treating Patients Who Are Undergoing Surgery to Remove a Metastatic Brain Tumor

Phase 1/2 Unknown

62 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT00014105 2013-12-04

Combination Chemotherapy in Treating Patients With Recurrent Glioblastoma Multiforme

Phase 1/2 Unknown

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00009854 2013-11-06

Carmustine Followed By Surgery in Treating Patients With Recurrent Supratentorial Malignant Glioma or Metastatic Brain Neoplasm

Phase 1/2 Unknown

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Neoplasm Metastasis, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00087061 2013-07-18

Gimatecan in Treating Patients With Recurrent or Progressive Primary Malignant Glioma

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00039572 2013-06-26

Boron Neutron Capture Therapy in Treating Patients With Glioblastoma Multiforme or Melanoma Metastatic to the Brain

CNSDermatologicSarcoma

Brain Neoplasms, Glioblastoma, Melanoma, Neoplasm Metastasis, Central Nervous System Neoplasms, Gliosarcoma

NCT00006093 2013-06-24

EMD 121974 in Treating Patients With Progressive or Recurrent Glioma

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00006268 2013-06-24

Immunotoxin Therapy in Treating Patients With Malignant Glioma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00012038 2013-06-24

Chemotherapy in Treating Patients With Progressive or Recurrent Brain Tumors

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00003301 2013-06-21

Irinotecan in Treating Patients With Recurrent Malignant Glioma

Astrocytoma, Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00004004 2013-06-21

Procarbazine in Treating Patients With Recurrent Brain Tumor

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00004147 2013-06-21

COL-3 in Treating Patients With Progressive or Recurrent Brain Tumors

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00005855 2013-06-21

Efaproxiral Plus Carmustine in Treating Patients With Progressive or Recurrent Malignant Glioma

48 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00352313 2012-05-02

ATN-161 and Carboplatin in Treating Patients With Recurrent Malignant Glioma

82 enrolled