Clinical Trials Browser

Phase 1/2 × Recruiting × Brain Neoplasms × Clear all

NCT05588141 2026-04-16

A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

Phase 1/2 Recruiting

Brain Neoplasms, Glioma, Neoplasms, Recurrence

NCT06012695 2026-04-13

NBM-BMX Administered Orally to Patients With Solid Tumors or Newly Diagnosed Glioblastoma

Phase 1/2 Recruiting

Brain Neoplasms, Neoplasms

NCT06810544 2026-04-13

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

Phase 1/2 Recruiting

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioblastoma, Glioma, Lung Neoplasms

NCT06329570 2026-04-09

Safety and Efficacy of Bevacizumab in Combination With NaviFUS System for the Treatment of Recurrent Glioblastoma Multiforme (rGBM)

Phase 1/2 Recruiting

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neoplasms, Nerve Tissue

NCT05987644 2026-04-08

DURABLE

Phase 1/2 Recruiting

Brain Neoplasms, Lung Neoplasms

NCT05386108 2026-04-06

ELECTRA

Phase 1/2 Recruiting

Brain Diseases, Brain Neoplasms, Breast Diseases, Breast Neoplasms, Central Nervous System Diseases, Neoplasms, Neoplasms by Site, Central Nervous System Neoplasms

NCT03449238 2026-03-30

Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients

Phase 1/2 Recruiting

Brain Neoplasms, Breast Neoplasms

NCT04085887 2026-03-20

Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures

Phase 1/2 Recruiting

Brain Neoplasms

NCT06161519 2026-03-19

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

Phase 1/2 Recruiting

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Recurrence

NCT05789589 2026-03-04

ADORATION

Phase 1/2 Recruiting

Brain Neoplasms, Neoplasm Metastasis, Neoplasms

NCT06047379 2026-03-02

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

Phase 1/2 Recruiting

CNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Astrocytoma, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Glioblastoma, Melanoma, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Central Nervous System Neoplasms, Small Cell Lung Carcinoma

NCT03510208 2026-02-09

Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery

Phase 1/2 Recruiting

Brain Neoplasms, Glioma

NCT04923542 2026-02-06

Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases

Phase 1/2 Recruiting

Brain Neoplasms

NCT05588453 2026-01-12

Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain

Phase 1/2 Recruiting

CNSDermatologic

Brain Neoplasms, Melanoma

NCT04711824 2025-12-23

SOLARA

Phase 1/2 Recruiting

Brain Neoplasms, Breast Neoplasms

NCT06194929 2025-12-03

DETERMINE

Phase 1/2 Recruiting

CNSDermatologic

Brain Neoplasms, Melanoma

NCT07206498 2025-11-28

WAYWIN103

Phase 1/2 Recruiting

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT05786924 2025-11-20

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

Phase 1/2 Recruiting

CNSGastrointestinalHead & NeckMyeloidThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Histiocytosis

NCT05630209 2025-10-02

Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG)

Phase 1/2 Recruiting

Brain Neoplasms

NCT04977375 2025-09-03

Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma

Phase 1/2 Recruiting

Brain Neoplasms, Glioblastoma, Glioma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT06907043 2025-08-19

EIK1004-001

Phase 1/2 Recruiting

Brain Neoplasms

NCT01891318 2025-07-02

Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study

Phase 1/2 Recruiting

Brain Neoplasms

NCT05615623 2025-04-30

Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG

Phase 1/2 Recruiting

Brain Neoplasms

NCT05535413 2025-04-25

UTD1 Combined With Capecitabine in Metastatic HER2-negative Breast Cancer Patients With Brain Metastases

Phase 1/2 Recruiting

Brain Neoplasms

NCT02861898 2025-04-09

Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma

Phase 1/2 Recruiting

Brain Neoplasms, Glioblastoma

NCT03213002 2025-04-09

CAPTEM

Phase 1/2 Recruiting

Brain Neoplasms, Glioblastoma, Neoplasms

NCT01906385 2025-03-26

Maximum Tolerated Dose, Safety, and Efficacy of Rhenium Nanoliposomes in Recurrent Glioma (ReSPECT)

Phase 1/2 Recruiting

Brain Neoplasms, Glioblastoma, Glioma

NCT06640582 2024-11-05

BAH2472

Phase 1/2 Recruiting

Brain Neoplasms, Glioblastoma, Glioma, Meningioma

NCT06243003 2024-02-07

WBRT With Hippocampal-avoidance Technique Followed by SRT for Extensive-stage SCLC With Baseline Brain Metastases

Phase 1/2 Recruiting

Brain Neoplasms