Clinical Trials Browser

Phase 2 × Active not recruiting × Brain Neoplasms × Clear all

NCT03175432 2026-04-15

Bevacizumab and Atezolizumab With or Without Cobimetinib in Treating Patients With Untreated Melanoma Brain Metastases

Phase 2 Active not recruiting

CNSDermatologic

Brain Neoplasms, Melanoma

NCT04762069 2026-04-15

A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme

Phase 2 Active not recruiting

Brain Neoplasms, Glioblastoma

NCT03994796 2026-04-13

Genetic Testing in Guiding Treatment for Patients With Brain Metastases

Phase 2 Active not recruiting

Brain Neoplasms, Neoplasm Metastasis

NCT05267587 2026-03-31

Preop fSRS for Resectable Brain Metastases

Phase 2 Active not recruiting

Brain Neoplasms

NCT04074096 2026-03-25

BEPCOME-MB

Phase 2 Active not recruiting

CNSDermatologic

Brain Neoplasms, Melanoma

NCT06413706 2026-03-24

A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy

Phase 2 Active not recruiting

Brain Neoplasms, Glioma, Neoplasms, Spinal Cord Neoplasms

NCT04899908 2026-03-19

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

Phase 2 Active not recruiting

BreastCNSDermatologicGastrointestinalThoracic

Brain Neoplasms, Breast Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Colorectal Neoplasms

NCT04817254 2026-03-18

Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

Phase 2 Active not recruiting

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT02971501 2026-03-17

Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases

Phase 2 Active not recruiting

7 enrolled 9 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT05323955 2026-03-17

BRIDGET

Phase 2 Active not recruiting

Brain Neoplasms

NCT05865990 2026-03-12

TUXEDO-3

Phase 2 Active not recruiting

Brain Neoplasms, Breast Neoplasms, Meningeal Neoplasms

NCT06048718 2026-03-10

TUXEDO-4

Phase 2 Active not recruiting

Brain Neoplasms, Breast Neoplasms

NCT02568267 2026-03-06

STARTRK-2

Phase 2 Active not recruiting

534 enrolled 2 FDA

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidNETSarcomaThoracic

Thyroid Cancer, Papillary, Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Head and Neck Neoplasms, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Colorectal Neoplasms, Lymphoma, Large-Cell, Anaplastic, Cholangiocarcinoma, Neuroendocrine Tumors

NCT01644591 2026-03-05

Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain Metastases

Phase 2 Active not recruiting

CNSDermatologic

Brain Neoplasms, Melanoma

NCT04516070 2026-03-05

Stereotactic Radiosurgery for the Treatment of Patients With Small Cell Lung Cancer Brain Metastasis

Phase 2 Active not recruiting

Brain Neoplasms, Lung Neoplasms, Small Cell Lung Carcinoma

NCT02574728 2026-03-02

AflacST1502

Phase 2 Active not recruiting

CNSMyeloidSarcoma

Brain Neoplasms, Carcinoma, Ependymoma, Histiocytosis, Langerhans-Cell, Medulloblastoma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Neuroblastoma, Pinealoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT04049669 2026-01-08

Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG

Phase 2 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioblastoma, Medulloblastoma

NCT05503251 2025-12-24

Neuropsychological Care for Maintaining Quality of Life After Radiation Therapy in Patients With Brain Metastases

Phase 2 Active not recruiting

Brain Neoplasms, Neoplasm Metastasis

NCT05305365 2025-12-23

Study Assessing QBS72S For Treating Brain Metastases

Phase 2 Active not recruiting

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms, Meningeal Neoplasms

NCT00756639 2025-12-17

Prophylactic Cranial Irradiation (PCI) for Small Cell Carcinoma of the Urothelium

Phase 2 Active not recruiting

CNSGenitourinary

Adenocarcinoma, Urinary Bladder Neoplasms, Brain Neoplasms, Carcinoma, Transitional Cell

NCT02910700 2025-12-17

Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma

Phase 2 Active not recruiting

CNSDermatologic

Brain Neoplasms, Melanoma

NCT05128903 2025-12-15

Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study

Phase 2 Active not recruiting

Brain Neoplasms, Medulloblastoma

NCT02374242 2025-12-10

ABC

Phase 2 Active not recruiting

CNSDermatologic

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT01878617 2025-11-13

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

Phase 2 Active not recruiting

Brain Neoplasms, Medulloblastoma, Infratentorial Neoplasms, Neuroectodermal Tumors, Primitive

NCT02792582 2025-11-12

A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection

Phase 2 Active not recruiting

Brain Neoplasms, Craniopharyngioma

NCT06020066 2025-09-15

SRS for NSCLC With Oligo-residual Intracranial Disease After First-line 3rd Generation EGFR-TKI

Phase 2 Active not recruiting

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT02981940 2025-09-02

A Study of Abemaciclib in Recurrent Glioblastoma

Phase 2 Active not recruiting

45 enrolled 10 charts

Brain Neoplasms, Glioblastoma

NCT03753685 2025-07-23

X-396(Ensartinib) Capsules in ALK-Positive NSCLC Patients With Brain Metastases

Phase 2 Active not recruiting

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT03220646 2025-07-09

Abemaciclib (LY2835219) in Patients With Recurrent Primary Brain Tumors

Phase 2 Active not recruiting

Astrocytoma, Brain Neoplasms, Ependymoma, Meningioma, Oligodendroglioma

NCT04647916 2025-04-24

Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases

Phase 2 Active not recruiting

Brain Neoplasms

NCT05012254 2025-04-09

NIVIPI-Brain

Phase 2 Active not recruiting

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Diseases, Lung Neoplasms

NCT03769103 2024-10-31

Study of Osimertinib + SRS vs Osimertinib Alone for Brain Metastases in EGFR Positive Patients With NSCLC

Phase 2 Active not recruiting

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT05139043 2024-09-19

Low Dose Versus Standard Dose Dexamethasone for Reduction of Swelling in Patients with Primary or Metastatic Brain Tumors

Phase 2 Active not recruiting

Brain Neoplasms

NCT02886585 2024-03-12

Pembrolizumab In Central Nervous System Metastases

Phase 2 Active not recruiting

Brain Neoplasms

NCT03363217 2023-11-27

Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway.

Phase 2 Active not recruiting

Brain Neoplasms, Glioma, Neurofibromatosis 1, Neurofibroma, Plexiform