Clinical Trials Browser

Neuroinflammatory Diseases, Brain Neoplasms, Glioma, Meningioma, Multiple Sclerosis, Neoplasms, Neurilemmoma, Neurofibroma, Neuroma, Acoustic, Central Nervous System Neoplasms

NCT05465343 2025-12-19

Furmonertinib in EGFR-Mutant NSCLC With Brain Metastases (iFORCE)

Phase 2 Completed

24 enrolled

CNS

Brain Neoplasms

NCT04738162 2025-12-10

Clinical Safety Study on 5-Aminolevulinic Acid (5-ALA) in Children and Adolescents With Brain Tumors

Phase 2 Completed

78 enrolled

CNS

Brain Neoplasms

NCT04503772 2025-12-04

STEP

Phase 2 Completed

70 enrolled

CNS

Brain Neoplasms

NCT06439420 2025-10-01

CBT-I in PBT

Phase 2 Completed

70 enrolled

CNSLymphoid

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Sleep Initiation and Maintenance Disorders, Lymphoma, Meningioma, Oligodendroglioma

NCT03050736 2025-09-04

Safety Study of VAL-083 and Radiotherapy in Patients With Newly Diagnosed GBM Having Unmethylated MGMT Expression

Phase 2 Completed

29 enrolled

CNS

Brain Neoplasms, Glioblastoma, Glioma

NCT02717962 2025-08-29

Study of VAL-083 in Patients With MGMT Unmethylated, Bevacizumab-naive Glioblastoma in the Adjuvant or Recurrent Setting

Phase 2 Completed

118 enrolled

CNS

Brain Neoplasms, Glioblastoma, Glioma

NCT01931098 2025-08-11

Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab

Phase 2 Completed

35 enrolled 13 charts

CNSSarcoma

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT03967522 2025-08-08

CABRAMET

Phase 2 Completed

26 enrolled

CNSGenitourinary

Brain Neoplasms, Carcinoma, Renal Cell

NCT02681549 2025-08-07

Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer (NSCLC)

Phase 2 Completed

41 enrolled 20 charts

CNSDermatologicThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT01295944 2025-08-05

Carboplatin and Bevacizumab for Recurrent Ependymoma

Phase 2 Completed

35 enrolled 17 charts

CNS

Brain Neoplasms, Ependymoma, Neoplasms, Neurologic Manifestations, Spinal Cord Neoplasms

NCT03890952 2025-07-24

Translational Study of Nivolumab in Combination With Bevacizumab for Recurrent Glioblastoma

Phase 2 Completed

40 enrolled

CNS

Brain Neoplasms

NCT04410367 2025-07-20

PURSUE

Phase 2 Completed

23 enrolled 10 charts

CNS

Brain Neoplasms, Disease

NCT02986178 2025-07-11

Lerapolturev in Recurrent Malignant Glioma

Phase 2 Completed

121 enrolled 15 charts

CNS

Brain Neoplasms, Glioblastoma, Glioma, Recurrence

NCT03173950 2025-06-29

Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers

Phase 2 Completed

133 enrolled

CNS

Brain Neoplasms, Ependymoma, Medulloblastoma, Meningioma, Pinealoma, Spinal Cord Neoplasms, Choroid Plexus Neoplasms

NCT04420598 2025-06-24

DEBBRAH

Phase 2 Completed

41 enrolled 32 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Meningeal Carcinomatosis

NCT04743310 2025-06-13

Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System

Phase 2 Completed

50 enrolled

CNS

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Neuroma, Acoustic, Pinealoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT04479241 2025-06-05

LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients With Recurrent Glioblastoma

Phase 2 Completed

25 enrolled 12 charts

CNS

Brain Neoplasms, Glioblastoma

NCT01288235 2025-06-03

Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation

Phase 2 Completed

100 enrolled 11 charts

CNS

Astrocytoma, Brain Neoplasms, Ependymoma, Ganglioglioma

NCT03898908 2025-05-21

EBRAIN-MEL

Phase 2 Completed

48 enrolled 24 charts

CNSDermatologic

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT04452084 2025-03-20

Phase 2 Trial in Multiple Brain Metastases Outcomes With HA-SIB-WBRT

Phase 2 Completed

42 enrolled

CNS

Brain Neoplasms

NCT01894061 2025-02-17

NovoTTF-100A With Bevacizumab (Avastin) in Patients With Recurrent Glioblastoma

Phase 2 Completed

25 enrolled 16 charts

CNSSarcoma

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT04233021 2025-02-03

ORBITAL

Phase 2 Completed

57 enrolled

CNS

Brain Neoplasms, Meningeal Carcinomatosis

NCT04824079 2025-01-22

Keynatinib in Treated Patients With NSCLC and Brain Metastases

Phase 2 Completed

16 enrolled

CNS

Brain Neoplasms

NCT05146219 2024-12-30

Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation

Phase 2 Completed

29 enrolled

CNS

Brain Neoplasms, Meningeal Carcinomatosis

NCT04946019 2024-12-12

MR-Linac Guided Adaptive FSRT for Brain Metastases From Non-small Cell Lung Cancer

Phase 2 Completed

55 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT01817751 2024-07-17

Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma

Phase 2 Completed

47 enrolled 13 charts

CNS

Brain Neoplasms, Glioblastoma, Glioma, Neurologic Manifestations

NCT01244737 2024-07-11

FLT-PET Imaging of Brain Tumors in Children

Phase 2 Completed

50 enrolled 11 charts

CNS

Brain Neoplasms

NCT02978404 2024-06-28

Combining Radiosurgery and Nivolumab in the Treatment of Brain Metastases

Phase 2 Completed

26 enrolled

CNSDermatologicGenitourinaryThoracic

Clear-cell metastatic renal cell carcinoma, Brain Neoplasms, Melanoma, Small Cell Lung Carcinoma

NCT02014844 2024-05-29

Phase 2 Study to Investigate the Efficacy and Safety of Aldoxorubicin in Subjects With Glioblastoma

Phase 2 Completed

28 enrolled 10 charts

CNS

Brain Neoplasms, Glioblastoma

NCT02107755 2024-05-21

Stereotactic Radiation Therapy and Ipilimumab in Treating Patients With Metastatic Melanoma

Phase 2 Completed

8 enrolled 12 charts

CNSDermatologic

Brain Neoplasms, Melanoma

NCT01472731 2024-05-06

Safety and Imaging Study of GC1008 in Glioma

Phase 2 Completed

12 enrolled

CNS

Brain Neoplasms

NCT02798029 2024-04-23

Frameless Fractionated Stereotactic Radiation in Treating Patients With Brain Metastases

Phase 2 Completed

35 enrolled

CNS

Brain Neoplasms

NCT03257631 2024-04-16

A Study of Pomalidomide Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors

Phase 2 Completed

53 enrolled 18 charts

CNS

Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Central Nervous System Neoplasms

NCT02340884 2024-04-09

A Pilot RCT of the PRISM Intervention for AYAs With Cancer

Phase 2 Completed

92 enrolled

CNSLymphoidOther hematologic neoplasmSarcoma

Brain Neoplasms, Lymphoma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Sarcoma, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00445965 2024-04-04

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

Phase 2 Completed

78 enrolled 11 charts

CNSDermatologicGynecologicOther solid neoplasmSarcomaThoracic

Familial ependymoma, Uveal Melanoma, Astrocytoma, Brain Neoplasms, Chondrosarcoma, Ependymoma, Glioblastoma, Glioma, Lung Neoplasms, Medulloblastoma, Melanoma, Neoplasm Metastasis, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Glioma, Subependymal, Gliosarcoma, Rhabdoid Tumor, Optic Nerve Glioma, Small Cell Lung Carcinoma, Desmoplastic Small Round Cell Tumor

NCT03925246 2024-04-02

REVOLUMAB

Phase 2 Completed

43 enrolled

CNS

Brain Neoplasms, Glioma

NCT06289023 2024-03-01

HA-WBRT-SIB for Brain Metastasis of Lung Cancer

Phase 2 Completed

40 enrolled

CNSThoracic

Brain Neoplasms, Lung Neoplasms

NCT02073968 2024-01-25

PAINT

Phase 2 Completed

35 enrolled 13 charts

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT01854554 2024-01-02

Glioblastoma Multiforme (GBM) Proton vs. Intensity Modulated Radiotherapy (IMRT)

Phase 2 Completed

90 enrolled 11 charts

CNS

Brain Neoplasms, Glioblastoma

NCT00002965 2023-12-22

Interferon Alfa in Treating Patients With Recurrent Unresectable Meningiomas and Malignant Meningiomas

Phase 2 Completed

16 enrolled

CNS

Brain Neoplasms, Central Nervous System Neoplasms

NCT02312622 2023-12-12

Phase 2 Etirinotecan Pegol in Refractory Brain Metastases & Advanced Lung Cancer / Metastatic Breast Cancer

Phase 2 Completed

27 enrolled 19 charts

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Small Cell Lung Carcinoma

NCT03027388 2023-11-22

Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma

Phase 2 Completed

7 enrolled 20 charts

CNS

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma

Clinical Trials

Sunitinib in Treating Patients With Kidney Cancer That Has Spread to the Brain

Trial Evaluating an Enhanced Physical Activity Intervention to Improve Cognitive Late Effects in Children Treated With Cranial Radiation for Brain Tumors

Cisplatin With or Without Veliparib in Treating Patients With Recurrent or Metastatic Triple-Negative and/or BRCA Mutation-Associated Breast Cancer With or Without Brain Metastases

Testing Ramipril to Prevent Memory Loss in People With Glioblastoma

UC-GlioFET

Immersive Virtual Reality (VR) at the Time of Clinical Evaluation to Improve Psychological Distress and Anxiety in Primary Brain Tumor (PBT) Patients

Low Dose Ipilimumab With Pembrolizumab in Treating Patients With Melanoma That Has Spread to the Brain

Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent

Furmonertinib in EGFR-Mutant NSCLC With Brain Metastases (iFORCE)

Clinical Safety Study on 5-Aminolevulinic Acid (5-ALA) in Children and Adolescents With Brain Tumors

STEP

CBT-I in PBT

Safety Study of VAL-083 and Radiotherapy in Patients With Newly Diagnosed GBM Having Unmethylated MGMT Expression

Study of VAL-083 in Patients With MGMT Unmethylated, Bevacizumab-naive Glioblastoma in the Adjuvant or Recurrent Setting

Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab

CABRAMET

Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer (NSCLC)

Carboplatin and Bevacizumab for Recurrent Ependymoma

Translational Study of Nivolumab in Combination With Bevacizumab for Recurrent Glioblastoma

PURSUE

Lerapolturev in Recurrent Malignant Glioma

Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers

DEBBRAH

Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System

LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients With Recurrent Glioblastoma

Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation

EBRAIN-MEL

Phase 2 Trial in Multiple Brain Metastases Outcomes With HA-SIB-WBRT

NovoTTF-100A With Bevacizumab (Avastin) in Patients With Recurrent Glioblastoma

ORBITAL

Keynatinib in Treated Patients With NSCLC and Brain Metastases

Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation

MR-Linac Guided Adaptive FSRT for Brain Metastases From Non-small Cell Lung Cancer

Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma

FLT-PET Imaging of Brain Tumors in Children

Combining Radiosurgery and Nivolumab in the Treatment of Brain Metastases

Phase 2 Study to Investigate the Efficacy and Safety of Aldoxorubicin in Subjects With Glioblastoma

Stereotactic Radiation Therapy and Ipilimumab in Treating Patients With Metastatic Melanoma

Safety and Imaging Study of GC1008 in Glioma

Frameless Fractionated Stereotactic Radiation in Treating Patients With Brain Metastases

A Study of Pomalidomide Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors

A Pilot RCT of the PRISM Intervention for AYAs With Cancer

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

REVOLUMAB

HA-WBRT-SIB for Brain Metastasis of Lung Cancer

PAINT

Glioblastoma Multiforme (GBM) Proton vs. Intensity Modulated Radiotherapy (IMRT)

Interferon Alfa in Treating Patients With Recurrent Unresectable Meningiomas and Malignant Meningiomas

Phase 2 Etirinotecan Pegol in Refractory Brain Metastases & Advanced Lung Cancer / Metastatic Breast Cancer

Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma