Clinical Trials Browser

Phase 3 × OTHER × Brain Neoplasms × Clear all

NCT07481786 2026-04-06

Bevacizumab Plus FSRT Versus Hippocampus-Avoidant WBRT in Lung Adenocarcinoma With Extensive Brain Metastases

Phase 3 Recruiting

Adenocarcinoma of Lung, Brain Neoplasms

NCT04804644 2026-04-03

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

Phase 3 Recruiting

Brain Neoplasms, Lung Neoplasms, Small Cell Lung Carcinoma

NCT05438212 2026-04-03

Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases

Phase 3 Active not recruiting

Brain Neoplasms

NCT06500455 2026-04-03

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

Phase 3 Recruiting

BreastCNSDermatologicGenitourinaryThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Lung Neoplasms, Melanoma, Neoplasm Metastasis

NCT06388733 2026-04-01

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

Phase 3 Recruiting

Brain Neoplasms, Glioblastoma

NCT06229483 2026-03-19

The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies

Phase 3 Recruiting

Brain Neoplasms, Hemorrhage

NCT01592968 2026-03-09

Stereotactic Radiosurgery or Whole Brain Radiation Therapy in Treating Patients With Newly Diagnosed Non-melanoma Brain Metastases

Phase 3 Active not recruiting

Brain Neoplasms, Neoplasm Metastasis

NCT06888817 2026-02-25

BRAINS

Phase 3 Recruiting

Brain Neoplasms, Glioma, Radiation Injuries

NCT00950001 2026-02-20

Stereotactic Radiosurgery Compared to Observation in Treating Patients With Brain Metastases

Phase 3 Active not recruiting

Brain Neoplasms

NCT06442748 2026-02-13

LIBRA

Phase 3 Recruiting

Brain Neoplasms, Seizures

NCT04706910 2026-02-09

18F-DOPA II - PET Imaging Optimization

Phase 3 Recruiting

CNSEndocrineNET

Brain Neoplasms, Neuroblastoma, Parkinson Disease, Neuroendocrine Tumors, Lewy Body Disease, Congenital Hyperinsulinism

NCT06159335 2026-02-03

18F-FLUC PET/MR in Patients With Brain Mets

Phase 3 Recruiting

Brain Neoplasms, Motor Activity

NCT07376304 2026-01-29

BrainUS-AI

Phase 3 Not yet recruiting

Brain Neoplasms, Glioblastoma, Glioma

NCT04114981 2026-01-26

Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease

Phase 3 Active not recruiting

Brain Neoplasms

NCT07329634 2026-01-09

RENESANS

Phase 3 Not yet recruiting

Brain Neoplasms

NCT03750227 2025-12-24

Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

Phase 3 Recruiting

Brain Neoplasms

NCT06905587 2025-12-11

EMBRAIN

Phase 3 Recruiting

Brain Neoplasms, Neoplasms

NCT07167134 2025-09-11

SISMIC

Phase 3 Not yet recruiting

Brain Neoplasms

NCT07165262 2025-09-10

ECOG-Anaes

Phase 3 Active not recruiting

Brain Neoplasms, Epilepsy

NCT03741673 2025-09-05

Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases

Phase 3 Recruiting

Brain Neoplasms, Neoplasms

NCT01951482 2025-08-17

Pemetrexed/Platinum With or Without Bevacizumab in Brain Metastases From Patients With EGFR/ALK Negative Non-Squamous Non-small Cell Lung Cancer

Phase 3 Completed

Brain Neoplasms

NCT06471465 2025-08-17

BRADI

Phase 3 Recruiting

Brain Neoplasms

NCT04474925 2025-07-18

Pre- Versus Post-operative SRS for Resectable Brain Metastases

Phase 3 Terminated

Brain Neoplasms

NCT06457906 2025-07-16

SHARP

Phase 3 Recruiting

Brain Neoplasms, Small Cell Lung Carcinoma

NCT04588246 2025-06-06

Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery

Phase 3 Terminated

19 enrolled 19 charts

BreastCNSDermatologicGastrointestinalGenitourinaryThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Small Cell Lung Carcinoma

NCT02360215 2025-04-23

Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases

Phase 3 Completed

518 enrolled 40 charts

Brain Neoplasms, Cognitive Dysfunction

NCT05897658 2024-10-23

LeviTaTe Pilot

Phase 3 Not yet recruiting

Brain Neoplasms, Seizures

NCT05271240 2024-09-19

Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM

Phase 3 Recruiting

Brain Neoplasms, Glioblastoma, Glioma

NCT04395339 2024-08-01

GLORY

Phase 3 Terminated

Brain Neoplasms, Breast Neoplasms, Gangliosidoses, Radiation Injuries, Gangliosidosis, GM1, Cognitive Dysfunction

NCT06477939 2024-06-27

THREE-GLEES

Phase 3 Not yet recruiting

Hypoxia, Brain Neoplasms, Glioblastoma

NCT05144867 2023-10-17

SRSvsWBRT

Phase 3 Unknown

Brain Neoplasms, Breast Neoplasms

NCT00548756 2023-06-07

Randomized Trial Comparing Radiosurgery With vs Without Whole Brain Radiotherapy

Phase 3 Completed

Brain Neoplasms

NCT05049707 2023-04-12

Does Perioperative Intravenous Magnesium Affect Postoperative Quality of Recovery in Craniotomy Surgery Patients?

Phase 3 Unknown

Brain Neoplasms

NCT05768490 2023-03-14

Early or Delayed Intervention of Brain Radiotherapy Combined With Almonertinib in EGFR Mutated NSCLC With Brain Metastases

Phase 3 Recruiting

Brain Neoplasms

NCT00377156 2022-09-16

Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases

Phase 3 Completed

213 enrolled 16 charts

BreastCNSGenitourinaryThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis, Prostatic Neoplasms, Breast Neoplasms, Male

NCT01372774 2022-09-16

Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery

Phase 3 Completed

194 enrolled 11 charts

Brain Neoplasms, Neoplasm Metastasis, Radiation Injuries, Neurotoxicity Syndromes

NCT03243461 2022-06-06

HIT-HGG-2013

Phase 3 Unknown

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neuroepithelial

NCT01951469 2022-03-08

Gefitinib With or Without Chemotherapy in Brain Metastases From Non-small Cell Lung Cancer

Phase 3 Unknown

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT00369785 2021-10-20

Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors

Phase 3 Completed

198 enrolled 10 charts

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Fatigue, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasm Metastasis, Oligodendroglioma, Pinealoma, Radiation Injuries, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Gliosarcoma

NCT00031798 2021-09-09

Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors

Phase 3 Terminated

Astrocytoma, Brain Neoplasms, Depression, Ependymoma, Fatigue, Glioblastoma, Glioma, Meningioma, Oligodendroglioma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Gliosarcoma

NCT04277403 2021-09-05

HipSter

Phase 3 Unknown

Brain Neoplasms

NCT00418691 2020-09-23

Effects of Methylphenidate Versus Sustained Release Methylphenidate on Cognitive Functioning

Phase 3 Terminated

34 enrolled 7 charts

Brain Neoplasms, Fatigue

NCT01014767 2019-08-20

Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus Tumors

Phase 3 Terminated

27 enrolled 1 chart

Brain Neoplasms, Choroid Plexus Neoplasms

NCT01942980 2018-08-13

Evaluation of the Efficacy of Hippocampal Avoidance on the Cognitive Toxicity of Whole-Brain Radiation Therapy After Surgical Resection of Single Brain Metastasis of Breast Cancer

Phase 3 Completed

Brain Neoplasms, Breast Neoplasms

NCT01601314 2018-01-17

MAGNA

Phase 3 Completed

Brain Neoplasms, Seizures

NCT02714010 2017-10-27

EGFR-TKI Concurrent With/Without WBRT in Brain Metastasis From NSCLC

Phase 3 Unknown

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT02563288 2017-07-27

Esmolol Versus Dexmedetomidine During Intracranial Procedures

Phase 3 Unknown

Brain Neoplasms, Intracranial Aneurysm

NCT00745797 2017-03-06

PCI

Phase 3 Terminated

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT01724801 2017-03-01

BRAIN

Phase 3 Completed

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT02972333 2016-11-23

Open Label, Prospective Study to Investigate Efficacy and Safety of AZD9291 in BM From NSCLC Patients With EGFR T790M

Phase 3 Unknown

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung