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NCT01068782 2026-02-25

Multiple Doses and Regimens of Cabozantinib in Subjects With Grade IV Astrocytic Tumors in First or Second Relapse

Phase 2 Terminated

19 enrolled 10 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT06098248 2025-12-15

cCeLLExvivo

Phase NA Terminated

285 enrolled 5 charts

Brain Neoplasms

NCT04543188 2025-10-23

A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement

Phase 1 Terminated

65 enrolled 52 charts

CNSDermatologicThoracic

Brain Diseases, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasms, Central Nervous System Neoplasms

NCT04712721 2025-10-10

Study of [68Ga]-FF58 in Patients With Selected Solid Tumors Expected to Overexpress αvβ3 and αvβ5 Integrins.

Phase EARLY_PHASE1 Terminated

Brain Neoplasms, Breast Neoplasms, Glioblastoma

NCT03149575 2025-09-04

STAR-3

Phase 3 Terminated

Brain Neoplasms, Glioblastoma, Glioma

NCT06038760 2025-07-30

PEAR-GLIO

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Neoplasms, Oligodendroglioma

NCT00538343 2025-05-29

RTA 744 in Breast Cancer Patients With Progression of Previously Irradiated Brain Metastases

Phase 2 Terminated

Brain Neoplasms, Breast Neoplasms

NCT05241873 2025-02-10

(Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations

Phase 1 Terminated

Adenocarcinoma, Brain Neoplasms, Bronchial Neoplasms, Carcinoma, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Thoracic Neoplasms

NCT03717142 2025-01-15

Feasibility of the LUM Imaging System for Detection of Cancer to the Brain

Phase NA Terminated

Brain Neoplasms, Glioblastoma

NCT04771897 2024-12-20

KONQUER

Phase 1 Terminated

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma

NCT05831995 2024-12-06

Safety and Effectiveness of ABM-168 in Adults with Advanced Solid Tumors.

Phase 1 Terminated

CNSDermatologicGastrointestinalThoracic

Brain Neoplasms, Glioblastoma, Lung Neoplasms, Melanoma, Pancreatic Neoplasms, Colorectal Neoplasms

NCT04525014 2024-10-31

PIRATE

Phase 1 Terminated

Brain Neoplasms, Neoplasms, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT03250299 2024-06-24

Microtubule-Targeted Agent BAL101553 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Phase 1 Terminated

26 enrolled 17 charts

Brain Neoplasms, Glioblastoma

NCT04901806 2024-03-28

Study of PBI-200 in Subjects With NTRK-Fusion-Positive Solid Tumors

Phase 1 Terminated

Brain Neoplasms, Desmoplastic Small Round Cell Tumor

NCT02905643 2024-02-22

Discerning Pseudoprogression vs True Tumor Growth in GBMs

Brain Neoplasms, Glioblastoma

NCT00089245 2023-12-26

Radiolabeled MAB Therapy in Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer

Phase 1 Terminated

Brain Neoplasms, Medulloblastoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor, Meningeal Carcinomatosis, Desmoplastic Small Round Cell Tumor

NCT04644315 2023-08-07

ALpha-T

Phase 2 Terminated

1 enrolled 5 charts

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidNETSarcomaThoracic

Thyroid Cancer, Papillary, Brain Neoplasms, Breast Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Renal Cell, Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Melanoma, Neoplasms, Neoplasms by Site, Ovarian Neoplasms, Pancreatic Neoplasms, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Salivary Gland Neoplasms, Sarcoma, Thoracic Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Lymphoma, Large-Cell, Anaplastic, Cholangiocarcinoma, Neuroendocrine Tumors

NCT03911869 2023-05-31

POLARIS

Phase 2 Terminated

13 enrolled 55 charts

CNSDermatologic

Brain Neoplasms, Melanoma

NCT01986348 2023-01-26

KING

Phase 2 Terminated

76 enrolled 16 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma

NCT00479765 2022-06-22

A Phase 1 / 2 Dose Escalation Study of Locally-Administered OncoGel™ in Subjects With Recurrent Glioma

Phase 1/2 Terminated

4 enrolled 5 charts

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Recurrence

NCT03332589 2022-05-20

E6201 Plus Dabrafenib for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS)

Phase 1 Terminated

4 enrolled 9 charts

CNSDermatologic

Brain Neoplasms, Melanoma

NCT02154529 2022-04-27

Study of the Combination of KD019 and Trastuzumab in Subjects With HER2-Positive Metastatic Breast Cancer

Phase 1/2 Terminated

17 enrolled 19 charts

Brain Neoplasms

NCT02765165 2021-07-23

Phase 1/2 Study of USL311 +/- Lomustine in Advanced Solid Tumors or Relapsed/Recurrent Glioblastoma Multiforme (GBM)

Phase 1/2 Terminated

26 enrolled 20 charts

Brain Neoplasms, Glioblastoma, Neoplasms, Recurrence

NCT03967093 2021-07-22

KOURAGE

Phase 1 Terminated

Brain Neoplasms, Ependymoma, Neoplasms

NCT04327011 2020-03-30

A Continuation Protocol for Patients Previously Enrolled in a Study of Toca 511

Phase 1 Terminated

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma

NCT01349036 2020-03-03

A Phase 2 Study of PLX3397 in Patients With Recurrent Glioblastoma

Phase 2 Terminated

38 enrolled 13 charts

Brain Neoplasms, Glioblastoma

NCT03471702 2019-07-11

A Secondary Study Evaluating Aqueduct's Smart External Drain (SED)

Phase NA Terminated

Brain Neoplasms, Hydrocephalus, Subarachnoid Hemorrhage

NCT01497665 2019-01-22

GRABM-L

Phase 2 Terminated

16 enrolled 7 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT01978236 2018-08-17

Dabrafenib/Trametinib, BRAF or BRAF AND MEK Pre-op With BRAF and MEK Post-op, Phase IIB, Melanoma With Brain Mets,Biomarkers and Metabolites

Phase 2 Terminated

6 enrolled 9 charts

CNSDermatologic

Brain Neoplasms, Melanoma

NCT01229644 2018-07-05

Study of Crenolanib, a Selective and Potent Inhibitor of PDGFR, for the Treatment of Adult Gliomas

Phase 2 Terminated

Brain Neoplasms, Glioma

NCT01870726 2018-05-30

Safety and Efficacy of INC280 and Buparlisib (BKM120) in Patients With Recurrent Glioblastoma

Phase 1/2 Terminated

43 enrolled 22 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00638963 2017-06-14

STOP

Phase 2 Terminated

6 enrolled 9 charts

Brain Neoplasms, Breast Neoplasms, Neoplasms, Second Primary

NCT00034697 2017-05-23

Study of Temozolomide in the Treatment of Brain Metastasis From Non-small-cell Lung Cancer (Study P02143)

Phase 2 Terminated

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT00171938 2017-02-24

Open-label Trial of Imatinib Mesylate in Patients With Unresectable Recurrent Glioblastoma Multiforme Expressing PDGFR (Platelet Derived Growth Factor Receptors)

Phase 2 Terminated

Brain Neoplasms, Glioblastoma

NCT02370563 2016-09-02

PET Imaging of Intracranial Cancers With 18F-FSPG

Phase 1 Terminated

Brain Neoplasms

NCT01132664 2016-08-17

Phase 1b/2 Study of BKM120 Plus Trastuzumab in Patients With HER2-positive Breast Cancer

Phase 1/2 Terminated

72 enrolled 15 charts

Brain Neoplasms, Breast Neoplasms

NCT01756729 2016-03-02

Post-approval Study of NovoTTF-100A in Recurrent GBM Patients

Phase 4 Terminated

Brain Neoplasms, Glioblastoma, Recurrence

NCT00437073 2015-10-15

Brain Metastases In ErbB2-Positive Breast Cancer

Phase 2 Terminated

22 enrolled 8 charts

Brain Neoplasms, Breast Neoplasms

NCT00761280 2014-11-14

SAPPHIRE

Phase 3 Terminated

27 enrolled 28 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Neoplasms

NCT00121420 2014-05-09

Study of Motexafin Gadolinium With Whole Brain Radiation Therapy Followed by Stereotactic Radiosurgery Boost in the Treatment of Patients With Brain Metastases

Phase 2 Terminated

BreastCNSDermatologicGenitourinaryThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Kidney Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis

NCT01369121 2013-07-30

Tolerability Study of Xerecept® in Pediatric Patients

Phase 1/2 Terminated

Brain Edema, Brain Neoplasms, Edema

NCT00696943 2013-02-15

18F ML-10 for Early Detection of Response of Brain Metastases to SRS

Phase 2 Terminated

Brain Neoplasms

NCT00872482 2011-07-01

A Study of Nimotuzumab in Combination With Radiation Therapy in Patients With Brain Metastases

Phase 2 Terminated

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT01018290 2011-06-08

Navigated Transcranial Magnetic Stimulation in Tumor Surgery

Brain Neoplasms

NCT00826930 2010-08-12

Trans Sodium Crocetinate (TSC) Study of Intra-tumoral Oxygen Concentration, Safety, and Pharmacokinetics in Patients With High Grade Glioma

Phase 1 Terminated

Brain Neoplasms, Glioma

NCT00730262 2009-12-30

Efficacy Study of TLN-4601 in Patients With Recurring Glioblastoma Multiforme

Phase 2 Terminated

Brain Neoplasms, Glioblastoma

NCT00234442 2009-06-30

Iressa in the Treatment of Brain Metastases From Non Small Cell Lung Cancer

Phase 2 Terminated

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT00691522 2009-01-09

Imaging Study of XERECEPT® Treatment for Peritumoral Brain Edema (PBE)

Phase 2 Terminated

Brain Neoplasms

NCT00115453 2008-08-18

Boron Neutron Capture Therapy (BNCT) as Treatment of Glioblastoma

Phase 1/2 Terminated

Brain Neoplasms, Glioblastoma