Clinical Trials

CNSDermatologicHead & NeckThoracic

124 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioma, Melanoma, Neoplasms, Thyroid Neoplasms

NCT02650401 2026-03-25

STARTRK-NG

CNSEndocrineGenitourinaryHead & NeckSarcoma

69 enrolled 2 FDA

Thyroid Cancer, Papillary, Brain Neoplasms, Glioma, Medulloblastoma, Neoplasm Metastasis, Wilms Tumor, Neuroblastoma, Recurrence, Salivary Gland Neoplasms, Sarcoma, Sarcoma, Ewing, Central Nervous System Neoplasms, Nephroma, Mesoblastic

NCT07492680 2026-03-25

A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

Phase 2 Not yet recruiting

260 enrolled

CNSDermatologicGastrointestinal

Brain Neoplasms, Melanoma, Pancreatic Neoplasms

NCT06413706 2026-03-24

A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy

Phase 2 Active not recruiting

45 enrolled

Brain Neoplasms, Glioma, Neoplasms, Spinal Cord Neoplasms

NCT03714243 2026-03-20

BBBD

Phase NA Completed

8 enrolled

Brain Neoplasms, Breast Neoplasms

NCT07297212 2026-03-12

A Clinical Trial Testing the Safety of the Investigational Drug Pumitamig (BNT327) and How Well it Works in Patients With Recurrent Glioblastoma

Phase 2 Recruiting

75 enrolled

Phase 2 Active not recruiting

Brain Neoplasms, Glioblastoma

NCT02568267 2026-03-06

STARTRK-2

534 enrolled 2 FDA

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidNETSarcomaThoracic

Thyroid Cancer, Papillary, Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Head and Neck Neoplasms, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Colorectal Neoplasms, Lymphoma, Large-Cell, Anaplastic, Cholangiocarcinoma, Neuroendocrine Tumors

NCT04238819 2026-03-02

A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including Neuroblastoma

Phase 1/2 Completed

47 enrolled 36 charts

CNSSarcoma

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT06047379 2026-03-02

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

CNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

134 enrolled

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Astrocytoma, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Glioblastoma, Melanoma, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Central Nervous System Neoplasms, Small Cell Lung Carcinoma

NCT01068782 2026-02-25

Multiple Doses and Regimens of Cabozantinib in Subjects With Grade IV Astrocytic Tumors in First or Second Relapse

Phase 2 Terminated

19 enrolled 10 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT05593094 2026-02-25

A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid Tumors

210 enrolled

Phase 2 Not yet recruiting

Brain Neoplasms

NCT07428616 2026-02-24

A Study of Zanzalintinib in Participants With Recurrent or Progressive Meningioma

100 enrolled

Brain Neoplasms, Meningioma

NCT05124912 2026-02-20

REMASTer: REcurrent Brain Metastases After SRS Trial

Phase NA Recruiting

261 enrolled

Phase 3 Active not recruiting

Brain Neoplasms, Neoplasm Metastasis, Recurrence

NCT04739761 2026-02-11

DESTINY-B12

506 enrolled 27 charts

Brain Neoplasms, Breast Neoplasms

NCT04478279 2026-02-09

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

BreastCNSDermatologicGenitourinary

125 enrolled

Brain Neoplasms, Breast Neoplasms, Glioblastoma, Melanoma, Prostatic Neoplasms

NCT06057168 2026-01-29

GDX-44-016

Phase 3 Completed

138 enrolled 7 charts

Brain Neoplasms

NCT06458712 2026-01-16

Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies

90 enrolled

Kenny-Caffey syndrome, Type 1, Brain Neoplasms

NCT06322342 2025-12-26

Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent

Phase 2 Completed

18 enrolled

Neuroinflammatory Diseases, Brain Neoplasms, Glioma, Meningioma, Multiple Sclerosis, Neoplasms, Neurilemmoma, Neurofibroma, Neuroma, Acoustic, Central Nervous System Neoplasms

NCT03423628 2025-12-22

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

180 enrolled

Brain Neoplasms, Glioblastoma, Inhibition, Psychological, Meningeal Neoplasms, Hereditary Sensory and Autonomic Neuropathies

NCT06098248 2025-12-15

cCeLLExvivo

Phase NA Terminated

285 enrolled 5 charts

Phase NA Not yet recruiting

Brain Neoplasms

NCT07274397 2025-12-10

EARLYBRAINPET

15 enrolled

Brain Neoplasms, Glioblastoma

NCT05256290 2025-12-09

Phase 1/2 Study of Silevertinib (BDTX-1535) in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations

200 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT04538742 2025-12-08

DB-07

245 enrolled

Brain Neoplasms, Breast Neoplasms

NCT06764940 2025-11-28

A Pivotal Phase II Clinical Trial of Utidelone Injection Plus Capecitabine in HER2-negative Breast Cancer Patients With Brain Metastases

Phase 2 Recruiting

120 enrolled

Brain Neoplasms, Breast Neoplasms

NCT07206498 2025-11-28

WAYWIN103

48 enrolled

Phase 1 Not yet recruiting

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT07254845 2025-11-28

A PROSPECTIVE, SINGLE-CENTERED, ASSESSOR-BLINDED STUDY TO EVALUATE THE CLINICAL EFFICACY OF THE PROPOSED CELL/TISSUE HISTOPATHOLOGY PROCESSOR CCELL (CONFOCAL FLUORESCENCE ENDOMICROSCOPY) FOR INTRAOPERATIVE DIAGNOSIS IN BRAIN TUMORS

30 enrolled

Brain Neoplasms

NCT06777433 2025-11-24

RAD101

Phase 2 Recruiting

30 enrolled

Brain Neoplasms

NCT05786924 2025-11-20

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

CNSGastrointestinalHead & NeckMyeloidThoracic

554 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Histiocytosis

NCT02831959 2025-10-31

Pivotal, Open-label, Randomized Study of Radiosurgery With or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases From Non-small Cell Lung Cancer (NSCLC).

Phase 3 Completed

298 enrolled

Phase EARLY_PHASE1 Terminated

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT04543188 2025-10-23

A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement

Phase 1 Terminated

65 enrolled 52 charts

CNSDermatologicThoracic

Brain Diseases, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasms, Central Nervous System Neoplasms

NCT04712721 2025-10-10

Study of [68Ga]-FF58 in Patients With Selected Solid Tumors Expected to Overexpress αvβ3 and αvβ5 Integrins.

14 enrolled

Phase 3 Active not recruiting

Brain Neoplasms, Breast Neoplasms, Glioblastoma

NCT04365374 2025-10-07

Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study)

230 enrolled

Brain Neoplasms, Neoplasm Metastasis, Neoplasms

NCT05630209 2025-10-02

Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG)

10 enrolled

Brain Neoplasms

NCT06136884 2025-10-01

A First-In-Human, Phase 1 Study Evaluating Oral TACC3 PPI Inhibitor, AO-252, in Advanced Solid Tumors With or Without Brain Metastases

86 enrolled

Phase 3 Active not recruiting

Brain Neoplasms

NCT04674683 2025-09-24

Study Comparing Investigational Drug HBI-8000 + Nivolumab vs. Placebo + Nivolumab in Patients With Advanced Melanoma

450 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT05023551 2025-09-16

Study of DSP-0390 in Patients With Recurrent High-Grade Glioma

Phase EARLY_PHASE1 Active not recruiting

39 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT03653546 2025-09-10

BM

Phase 2/3 Completed

492 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasms, Respiratory Tract Diseases

NCT03050736 2025-09-04

Safety Study of VAL-083 and Radiotherapy in Patients With Newly Diagnosed GBM Having Unmethylated MGMT Expression

Phase 2 Completed

29 enrolled