Clinical Trials Browser

Terminated × NIH × Brain Neoplasms × Clear all

NCT02942264 2026-02-23

Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma

Phase 1/2 Terminated

53 enrolled 22 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Recurrence, Gliosarcoma

NCT01217411 2024-11-19

RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer

Phase 1/2 Terminated

5 enrolled 6 charts

BreastCNSDermatologicThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Breast Neoplasms, Male, Small Cell Lung Carcinoma

NCT03190967 2023-10-11

T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery

Phase 1/2 Terminated

12 enrolled 16 charts

Brain Neoplasms, Breast Neoplasms

NCT03641326 2022-04-19

Sunitinib in Sarcomas of the Central Nervous System

Phase 2 Terminated

5 enrolled 14 charts

Brain Neoplasms, Gliosarcoma

NCT00000723 2021-10-28

The Use of Chemotherapy Plus Radiotherapy Plus Azidothymidine in Patients With AIDS-Related Lymph Node Cancer

Phase NA Terminated

Acquired Immunodeficiency Syndrome, Brain Neoplasms, Lymphoma, Lymphoma, Non-Hodgkin, HIV Infections, AIDS-Related Opportunistic Infections

NCT00031538 2019-12-09

Genetic Analysis of Brain Tumors

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma

NCT00108056 2019-12-05

Enzastaurin to Treat Recurrent Brain Tumor

Phase 1 Terminated

Brain Neoplasms, Glioma, Neoplasms, Disease Progression

NCT01251913 2019-12-03

A Pilot Study of Inpatient Hospice With Procurement of Brain Tumor Tissue on Expiration for Research Purposes

Astrocytoma, Brain Neoplasms, Ependymoma, Glioma, Pinealoma, Neuroectodermal Tumors, Primitive

NCT02692898 2019-11-19

Biomarker Analysis of Central Nervous System Tumors

Brain Neoplasms, Central Nervous System Neoplasms

NCT00880061 2018-07-05

An Open Label Dose Escalation Safety Study of Convection-Enhanced Delivery of IL13-PE38QQR in Patients With Progressive Pediatric Diffuse Infiltrating Brainstem Glioma and Supratentorial High-grade Glioma

Phase 1 Terminated

Brain Neoplasms, Glioma

NCT01281982 2018-07-05

(11C)dLop as a Marker of P-Glycoprotein Function in Patients With Gliomas

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma

NCT00096265 2018-03-09

Radiation Therapy and Stereotactic Radiosurgery With or Without Temozolomide or Erlotinib in Treating Patients With Brain Metastases Secondary to Non-Small Cell Lung Cancer

Phase 3 Terminated

126 enrolled 14 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT00112866 2017-06-14

Cilengitide in Treating Patients Who Are Undergoing Surgery for Recurrent or Progressive Glioblastoma Multiforme

Phase 2 Terminated

30 enrolled 10 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT01122901 2017-05-03

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Recurrent or Progressive Glioblastoma

Phase 2 Terminated

47 enrolled 9 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00436436 2017-03-28

O(6)-Benzylguanine and Temozolomide in Treating Patients With Glioblastoma Multiforme That Did Not Respond to Previous Temozolomide and Radiation Therapy

Phase 2 Terminated

12 enrolled 10 charts

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT01189240 2015-12-14

RO4929097and Bevacizumab in Treating Patients With Progressive or Recurrent Malignant Glioma

Phase 1/2 Terminated

13 enrolled 13 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT00923117 2015-09-30

Sunitinib to Treat Recurrent Brain Cancer

Phase 2 Terminated

87 enrolled 11 charts

Brain Neoplasms, Glioblastoma, Glioma

NCT01122888 2015-04-28

Cilengitide and Sunitinib Malate in Treating Patients With Advanced Solid Tumors or Glioblastoma Multiforme

Phase 1 Terminated

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT01378481 2014-12-23

High-Dose Vorinostat and Fractionated Stereotactic Body Radiation Therapy in Treating Patients With Recurrent Glioma

Phase 1 Terminated

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00937482 2013-03-08

Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases From Non-Small Cell Lung Cancer

Phase 1 Terminated

BreastCNSDermatologicGastrointestinalGenitourinaryThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Melanoma, Rectal Neoplasms, Breast Neoplasms, Male

NCT01269411 2013-02-07

RO4929097 in Treating Patients With Recurrent Invasive Gliomas

Phase 1 Terminated

Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00006773 2013-01-24

Bortezomib in Treating Patients With Recurrent Glioma

Phase 1 Terminated

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT00075491 2013-01-24

Neoadjuvant and Adjuvant Fenretinide Compared With Adjuvant Fenretinide Alone in Treating Patients Who Are Undergoing Surgical Resection For Recurrent Glioblastoma Multiforme

Phase 2 Terminated

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00393094 2012-07-13

Bevacizumab and Irinotecan to Treat Brain Tumors

Phase 2 Terminated

31 enrolled 12 charts

Brain Neoplasms, Glioma, Disease Progression