Clinical Trials Browser

Interventional × Breast Neoplasms × Denosumab × Clear all

NCT06374459 2026-04-20

Zunsemetinib in Combination With Capecitabine in Patients With Hormone Receptor-Positive and HER2-Negative Metastatic Breast Cancer With Bone Metastasis

Phase 1/2 Recruiting

Breast Neoplasms

NCT04549207 2026-04-07

Comparing Continuation or De-escalation of Bone Modifying Agents (BMA) in Patients Treated for Over 2 Years for Bone Metastases From Either Breast or Castration-resistant Prostate Cancer

Phase 4 Active not recruiting

Breast Neoplasms

NCT04067726 2026-03-31

TRIDENT

Phase 2 Active not recruiting

Breast Neoplasms

NCT02051218 2025-12-30

Prevention of Symptomatic Skeletal Events With Denosumab Administered Every 4 Weeks Versus Every 12 Weeks

Phase 3 Active not recruiting

BreastGenitourinary

Breast Neoplasms, Prostatic Neoplasms

NCT04711109 2025-04-02

BRCA-P

Phase 3 Active not recruiting

Breast Diseases, Breast Neoplasms, Neoplasms

NCT03629717 2024-10-16

RANKL Inhibition and Breast Tissue Biomarkers

Phase EARLY_PHASE1 Completed

Breast Neoplasms

NCT02613416 2024-08-23

Dmab

Phase 2 Completed

42 enrolled 6 charts

Breast Neoplasms

NCT03324932 2023-10-06

Efficacy of Denosumab on Normal BMD in Women Receiving Adjuvant Aromatase Inhibitors for Early Breast Cancer

Phase 3 Active not recruiting

Breast Neoplasms

NCT00556374 2023-07-27

Study to Determine Treatment Effects of Denosumab in Patients With Breast Cancer Receiving Aromatase Inhibitor Therapy

Phase 3 Completed

3,420 enrolled 19 charts

Breast Neoplasms

NCT00321464 2022-11-08

A Study Comparing Denosumab vs. Zoledronic Acid for the Treatment of Bone Metastases in Breast Cancer Subjects.

Phase 3 Completed

2,049 enrolled 16 charts

Breast Neoplasms, Fractures, Bone

NCT03691311 2021-11-03

D-BIOMARK

Phase EARLY_PHASE1 Unknown

Osteopetrosis, mild autosomal recessive form, Osteopetrosis, Autosomal Recessive 7, Breast Neoplasms

NCT02366130 2021-10-07

Trial of Ra-223 Dichloride in Combination With Hormonal Therapy and Denosumab in the Treatment of Patients With Hormone-Positive Bone-Dominant Metastatic Breast Cancer

Phase 2 Completed

45 enrolled 7 charts

Breast Neoplasms

NCT01077154 2021-09-28

Study of Denosumab as Adjuvant Treatment for Women With High Risk Early Breast Cancer Receiving Neoadjuvant or Adjuvant Therapy (D-CARE)

Phase 3 Terminated

4,509 enrolled 25 charts

Breast Neoplasms

NCT02721433 2020-12-02

REaCT-BTA

Phase 4 Completed

BreastGenitourinary

Breast Neoplasms, Neoplasm Metastasis, Prostatic Neoplasms

NCT02900469 2020-08-21

Presurgical Trial of Denosumab in Breast Cancer

Phase EARLY_PHASE1 Completed

Breast Neoplasms

NCT03532087 2020-01-18

PERIDENO

Phase 2 Withdrawn

Breast Neoplasms

NCT01952054 2019-11-22

Denosumab for Breast Cancer With Bone Mets

Phase 2 Terminated

7 enrolled 8 charts

Breast Neoplasms

NCT01419717 2019-09-24

Open-Label Access Protocol of Denosumab for Subjects With Advanced Cancer

Phase 3 Completed

129 enrolled 10 charts

BreastGenitourinary

Breast Neoplasms, Neoplasms, Prostatic Neoplasms

NCT03811509 2019-01-28

B-ABLE

Phase 4 Unknown

Breast Neoplasms, Osteoporosis, Arthralgia, Osteoporotic Fractures, Musculoskeletal Pain

NCT01864798 2018-11-27

D-Beyond

Phase 2 Terminated

Breast Neoplasms

NCT03070002 2018-11-20

Denosumab in Treating Patients With ER and/or PR Positive, HER2 Negative Metastatic Breast Cancer With Bone Metastases and Detectable Circulating Tumor Cells

Phase 2 Terminated

1 enrolled 6 charts

Breast Neoplasms, Neoplastic Cells, Circulating

NCT00089661 2018-10-17

AMG 162 in the Treatment of Bone Loss in Subjects Undergoing Aromatase Inhibitor Therapy for Non-metastatic Breast Cancer

Phase 3 Completed

252 enrolled 13 charts

Bone Diseases, Metabolic, Breast Neoplasms

NCT00896454 2018-10-17

Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium

Phase 2 Completed

33 enrolled 22 charts

BreastGastrointestinalGenitourinaryHead & NeckLymphoidPlasma cellThoracic

Humoral Hypercalcemia Of Malignancy, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Endocrine Gland Neoplasms, Head and Neck Neoplasms, Hodgkin Disease, Hypercalcemia, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Lymphoma, Non-Hodgkin, Multiple Myeloma, Neoplasm Metastasis, Neoplasms, Parathyroid Neoplasms, Thyroid Neoplasms

NCT00950911 2014-02-11

Open Label Extension to SRE Studies in United Kingdom and Czech Republic Only

Phase 3 Completed

35 enrolled 8 charts

BreastGenitourinaryPlasma cell

Breast Neoplasms, Multiple Myeloma, Neoplasms, Prostatic Neoplasms

NCT00091832 2014-01-28

Denosumab (AMG 162) in Bisphosphonate Naive Metastatic Breast Cancer

Phase 2 Completed

255 enrolled 34 charts

Breast Neoplasms, Neoplasm Metastasis, Neoplasms