Clinical Trials

29 enrolled 11 charts

Breast Neoplasms

NCT03424005 2026-03-16

Morpheus-panBC

Phase 1/2 Recruiting

792 enrolled

Phase 1 Active not recruiting

Breast Neoplasms

NCT03006172 2026-03-11

To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer

200 enrolled

Breast Neoplasms

NCT04300790 2025-07-29

METALLICA

69 enrolled

BreastEndocrine

Breast Neoplasms, Hyperglycemia, Neoplasm Metastasis, Multiple Endocrine Neoplasia Type 1

NCT02431676 2024-08-28

SPIRIT

BreastDermatologicGastrointestinalGenitourinaryGynecologicThoracic

121 enrolled 12 charts

Breast Neoplasms, Colonic Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Endometrial Neoplasms

NCT00984490 2024-02-01

Metformin Hydrochloride in Treating Women With Stage I or Stage II Breast Cancer That Can Be Removed By Surgery

Phase NA Terminated

5 enrolled 4 charts

Breast Neoplasms

NCT01101438 2023-09-13

A Phase III Randomized Trial of Metformin vs Placebo in Early Stage Breast Cancer

Phase 3 Completed

3,649 enrolled 17 charts

Phase EARLY_PHASE1 Completed

Breast Neoplasms, Breast Neoplasms, Male

NCT01980823 2023-08-30

Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer

23 enrolled

Breast Neoplasms

NCT04741204 2023-07-06

METBC

Phase 4 Withdrawn

Breast Neoplasms, Insulin Resistance, Racism

NCT05840068 2023-05-03

IGF Level in Breast Cancer Patients Treated With Metformin

Phase 4 Completed

107 enrolled

Breast Neoplasms

NCT05351021 2023-03-09

Efficacy of Metformin as Preventive Treatment in Paclitaxel Induced Peripheral Neuropathy in Breast Cancer Patients

76 enrolled

Breast Neoplasms, Peripheral Nervous System Diseases

NCT00930579 2022-10-20

Pre-Surgical Study: Effect of Metformin on Breast Cancer Proliferation

35 enrolled 5 charts

Breast Neoplasms

NCT02278965 2022-08-17

Metformin and Omega-3 Fatty Acids in Woman With a History of Early Stage Breast Cancer

19 enrolled

BreastCNSGastrointestinalGynecologic

Breast Carcinoma In Situ, Breast Neoplasms

NCT02201381 2022-07-18

METRICS

Phase 3 Withdrawn

Brain Neoplasms, Breast Neoplasms, Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Triple Negative Breast Neoplasms

NCT04143282 2021-12-07

Evaluation of the Effect of Metformin on Metastatic Breast Cancer as Adjuvant Treatment

250 enrolled

Breast Neoplasms

NCT05053841 2021-09-23

Implication of Metformin Plus Aromatase Inhibitor in Obese Postmenopausal Breast Cancer Women

45 enrolled

Breast Neoplasms

NCT01310231 2021-04-14

A Trial of Standard Chemotherapy With Metformin (vs Placebo) in Women With Metastatic Breast Cancer

40 enrolled 27 charts

Breast Neoplasms

NCT04559308 2020-09-22

The Effect of Metformin on Breast Cancer Patients

80 enrolled

Breast Neoplasms

NCT01627067 2020-06-19

Exemestane-RAD001-Metformin

23 enrolled 7 charts

Breast Neoplasms

NCT04387630 2020-06-11

Neoadjuvant Chemotherapy With or Without Metformin in Early Breast Cancer.

Phase 2/3 Unknown

120 enrolled

Breast Neoplasms

NCT01302379 2020-06-05

Reach for Health Study: Obesity-related Mechanisms and Mortality in Breast Cancer Survivors

Phase NA Completed

333 enrolled 17 charts

BreastOther

Breast Neoplasms, Obesity, Weight Loss

NCT04001725 2019-11-13

OPTIMAL

BreastCNSDermatologicThoracic

110 enrolled

Brain Neoplasms, Breast Neoplasms, Diabetes Mellitus, Lung Neoplasms, Melanoma, Neoplasms

NCT02472353 2019-10-16

Use of Metformin to Reduce Cardiac Toxicity in Breast Cancer

30 enrolled 10 charts

Breast Neoplasms, Neoplasms, Cardiotoxicity

NCT02506777 2019-09-04

MBC1

96 enrolled

Breast Neoplasms

NCT02506790 2019-09-04

Neoadjuvant Toremifene With Melatonin or Metformin in Locally Advanced Breast Cancer

96 enrolled

Breast Neoplasms

NCT01340300 2018-06-06

Exercise and Metformin in Colorectal and Breast Cancer Survivors

Phase EARLY_PHASE1 Completed

139 enrolled 18 charts

BreastGastrointestinal

Breast Neoplasms, Insulin Resistance, Motor Activity, Colorectal Neoplasms

NCT01793948 2018-03-30

Metformin Hydrochloride vs. Placebo in Overweight or Obese Patients at Elevated Risk for Breast Cancer

24 enrolled

BreastOther

Breast Neoplasms, Obesity

NCT01650506 2017-08-30

Study of Erlotinib and Metformin in Triple Negative Breast Cancer

8 enrolled

Breast Neoplasms

NCT02360059 2017-08-17

Metformin for Reduction of Paclitaxel-Related Neuropathy in Patients With Breast Cancer

1 enrolled 3 charts

Breast Neoplasms

NCT03192293 2017-06-20

Metformin and Simvastatin in Addition to Fulvestrant

28 enrolled

Breast Neoplasms

NCT00933309 2016-02-19

The Impact of Obesity and Obesity Treatments on Breast Cancer

25 enrolled

BreastOther

Breast Neoplasms, Obesity

NCT01885013 2016-01-01

MYME

126 enrolled

Breast Neoplasms

NCT00909506 2015-07-29

Efficacy and Safety of Adjuvant Metformin for Operable Breast Cancer Patients

105 enrolled

Breast Neoplasms

NCT01266486 2014-07-02

Effect of Metformin on Breast Cancer Metabolism

41 enrolled

Breast Neoplasms

NCT01477060 2014-02-20

Modulation of Response to Hormonal Therapy With Lapatinib and/or Metformin in Patients With Metastatic Breast Cancer

32 enrolled

Breast Neoplasms

NCT00659568 2013-05-30

Metformin and Temsirolimus in Treating Patients With Metastatic or Unresectable Solid Tumor or Lymphoma

BreastDermatologicGenitourinaryGynecologicLymphoidOther hematologic neoplasmThoracic

28 enrolled

Breast Neoplasms, Burkitt Lymphoma, Carcinoma, Renal Cell, Hodgkin Disease, Immunoblastic Lymphadenopathy, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Mycosis Fungoides, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Endometrial Neoplasms, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Small Cell Lung Carcinoma

NCT00897884 2012-01-19

Clinical and Biologic Effects of Metformin in Early Stage Breast Cancer

Phase NA Completed

39 enrolled