Announcements Trials
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Phase

Phase 2 12Phase 3 10Phase 1 5Phase NA 2Phase 2/3 2Phase EARLY_PHASE1 1Phase 1/2 1

Status

Recruiting 2Completed 2Not yet recruiting 1

Sponsor Class

OTHER 8INDUSTRY 5NIH 1

Study Type

Interventional 5

Sponsor

Cancer Type

Thoracic 2Gastrointestinal 2Gynecologic 1Genitourinary 1Breast 1

Conditions

Neoplasms 1520Carcinoma, Non-Small-Cell Lung 754Breast Neoplasms 572Neoplasm Metastasis 529Colorectal Neoplasms 445Melanoma 391Leukemia, Myeloid, Acute 371Multiple Myeloma 363Ovarian Neoplasms 352Recurrence 336Lymphoma 334Advanced Solid Tumors 324Lymphoma, Non-Hodgkin 314Prostatic Neoplasms 300Pancreatic Neoplasms 285Advanced Solid Tumor 240Stomach Neoplasms 232Carcinoma, Renal Cell 225Squamous Cell Carcinoma of Head and Neck 210Lung Neoplasms 210Solid Tumor 204Leukemia, Lymphocytic, Chronic, B-Cell 198Triple Negative Breast Neoplasms 183Solid Tumors 182Carcinoma, Hepatocellular 164Hematologic Neoplasms 155Head and Neck Neoplasms 152Lymphoma, Large B-Cell, Diffuse 148Lymphoma, Follicular 146Glioblastoma 145

Interventions

alkaloid GB18 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Phase 1 × INDUSTRY × Cachexia × Clear all
NCT07519564 2026-04-09

A Phase I Clinical Study to Evaluate the PK, PD, Efficacy, and Safety of GB18 Injection in Patients With Tumor Cachexia

Kexing Biopharm Co., Ltd.

Phase 1 Not yet recruiting
18 enrolled

Cachexia, Neoplasms

NCT05865535 2026-01-08

A Dose Escalation Study of AV-380 in Cancer Patients With Cachexia

AVEO Pharmaceuticals, Inc.

Phase 1 Recruiting
30 enrolled

Cachexia

NCT06898255 2025-06-05

A Phase I Study to Evaluate GFS202A in Advanced Solid Tumor Patients With Pre-cachexia or Cachexia

Genfleet Therapeutics (Shanghai) Inc.

Phase 1 Recruiting
36 enrolled

Cachexia, Neoplasms

NCT04803305 2024-01-12

Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia

Pfizer

Phase 1 Completed
18 enrolled 14 charts
BreastGastrointestinalGenitourinaryGynecologicThoracic

Anorexia, Breast Neoplasms, Cachexia, Carcinoma, Non-Small-Cell Lung, Fatigue, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms, Weight Loss

NCT04299048 2023-12-14

Study to Assess the Safety and Tolerability of Repeated Doses of an Investigational New Drug in Patients With Cancer and Cachexia.

Pfizer

Phase 1 Completed
11 enrolled 13 charts
GastrointestinalThoracic

Anorexia, Cachexia, Carcinoma, Non-Small-Cell Lung, Fatigue, Muscular Atrophy, Pancreatic Neoplasms, Colorectal Neoplasms, Weight Loss

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