Clinical Trials

Cardiovascular Diseases, Diabetes Mellitus, Fibrosis, Hepatitis C, Carcinoma, Hepatocellular, Hepatitis C, Chronic

NCT04145141 2026-04-14

National Translational Science Network of Precision-based Immunotherapy for Primary Liver Cancer

Active not recruiting

132 enrolled

Carcinoma, Hepatocellular, Liver Neoplasms, Cholangiocarcinoma

NCT02465060 2026-04-13

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmPlasma cellThoracic

6,452 enrolled 2 FDA

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Glioma, Carcinoma, Hepatocellular, Lung Neoplasms, Lymphoma, Melanoma, Multiple Myeloma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Uterine Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Hematologic Neoplasms

NCT02772003 2026-04-13

DNA Vaccine Therapy in Treating Patients With Chronic Hepatitis C Virus Infection

Phase 1 Active not recruiting

33 enrolled

Hepatitis, Chronic, Hepatitis C, Carcinoma, Hepatocellular

NCT02867592 2026-04-13

Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors

CNSEndocrineGastrointestinalGenitourinarySarcoma

109 enrolled 24 charts

Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Wilms Tumor, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Central Nervous System Neoplasms, Hepatoblastoma, Sarcoma, Clear Cell, Sarcoma, Alveolar Soft Part, Adrenocortical Carcinoma, Carcinoma, Medullary

NCT02968810 2026-04-13

Simvastatin in Preventing Liver Cancer in Patients With Liver Cirrhosis

52 enrolled 15 charts

BreastGastrointestinalGenitourinaryPlasma cell

Fibrosis, Carcinoma, Hepatocellular

NCT04955808 2026-04-13

Biospecimen Collection in Identifying Genetic Changes in Patients With Breast, Prostate, Colorectal, Liver, or Kidney Cancer or Multiple Myeloma Undergoing Surgery

Suspended

2,400 enrolled

Breast Neoplasms, Carcinoma, Renal Cell, Colonic Neoplasms, Carcinoma, Hepatocellular, Multiple Myeloma, Prostatic Neoplasms

NCT06811116 2026-04-13

Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial

Phase 1/2 Recruiting

92 enrolled

BreastGastrointestinalGenitourinaryGynecologicThoracic

Carcinoma, Hepatocellular

NCT06995898 2026-04-13

The Vanguard Study: Testing a New Way to Screen for Cancer

Phase NA Recruiting

24,000 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT05003895 2026-04-07

GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Solid Tumor Malignancies

Phase 1 Recruiting

38 enrolled

CNSEndocrineGastrointestinalGenitourinaryGynecologicOther solid neoplasmSarcomaThoracic

Carcinoma, Hepatocellular, Liver Neoplasms

NCT06503146 2026-03-27

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

Phase 2 Recruiting

320 enrolled

Urinary Bladder Neoplasms, Carcinoma, Hepatocellular, Mesothelioma, Ovarian Neoplasms, Paraganglioma, Pheochromocytoma, Sarcoma, Stomach Neoplasms, Cholangiocarcinoma, Small Cell Lung Carcinoma

NCT03937830 2026-03-24

Combined Treatment of Durvalumab, Bevacizumab, Tremelimumab and Transarterial Chemoembolization (TACE) in Subjects With Hepatocellular Carcinoma or Biliary Tract Carcinoma

27 enrolled

Phase 1 Active not recruiting

Carcinoma, Hepatocellular, Liver Neoplasms

NCT04514484 2026-03-23

Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV

8 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicSarcomaThoracic

Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Carcinoma, Hepatocellular, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Ovarian Neoplasms, Prostatic Neoplasms, Sarcoma, Kaposi, HIV Infections, Carcinoma, Medullary, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT03785210 2026-02-23

Nivolumab (Anti-PD1), Tadalafil and Oral Vancomycin in People With Refractory Primary Hepatocellular Carcinoma or Liver Dominant Metastatic Cancer From Colorectal or Pancreatic Cancers

22 enrolled 13 charts

Carcinoma, Hepatocellular, Liver Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms

NCT04258566 2026-02-02

Electromagnetic Tracking and Optical Imaging With ICG for Hepatic Biopsies

Phase NA Terminated

7 enrolled 10 charts

Carcinoma, Hepatocellular

NCT04175912 2025-11-17

Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the Liver

40 enrolled 11 charts

Carcinoma, Hepatocellular, Cholangiocarcinoma

NCT05009979 2025-08-28

18F-DCFPyL PET/CT in Hepatocellular Carcinoma

8 enrolled 14 charts

Carcinoma, Hepatocellular, Liver Neoplasms

NCT02143401 2024-11-22

Navitoclax and Sorafenib Tosylate in Treating Patients With Relapsed or Refractory Solid Tumors

29 enrolled

Fibrosis, Hepatitis B, Hepatitis C, Carcinoma, Hepatocellular, Neoplasm Metastasis, Neoplasms

NCT00059267 2024-11-15

Prevention of Recurrent Hepatitis B After Liver Transplantation

317 enrolled

Fibrosis, Hepatitis B, Carcinoma, Hepatocellular, Liver Failure, Acute

NCT01350648 2024-10-01

Long-Term Study of Liver Disease in People With Hepatitis B and/or Hepatitis C With or Without HIV Infection

569 enrolled

Acquired Immunodeficiency Syndrome, Hepatitis B, Hepatitis C, Carcinoma, Hepatocellular, Liver Neoplasms

NCT02595866 2024-08-09

Testing the Addition of an Experimental Medication MK-3475 (Pembrolizumab) to Usual Anti-Retroviral Medications in Patients With HIV and Cancer

DermatologicGastrointestinalLymphoidSarcomaThoracic

58 enrolled 17 charts

Carcinoma, Non-Small-Cell Lung, Carcinoma, Hepatocellular, Lung Neoplasms, Lymphoma, Non-Hodgkin, Melanoma, Neoplasm Metastasis, Neoplasms, Recurrence, Sarcoma, Kaposi, HIV Infections

NCT02273362 2024-03-26

Erlotinib Hydrochloride in Preventing Liver Cancer in Patients With Cirrhosis of the Liver

25 enrolled 10 charts

Fibrosis, Carcinoma, Hepatocellular

NCT00019630 2024-03-04

Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors

CNSGastrointestinalGenitourinaryGynecologicSarcoma

Familial ependymoma, Ovarian Germ Cell Cancer, Astrocytoma, Bone Neoplasms, Brain Neoplasms, Carcinoma, Renal Cell, Endocrine Gland Neoplasms, Gastrointestinal Neoplasms, Carcinoma, Hepatocellular, Medulloblastoma, Meningioma, Neoplasms, Wilms Tumor, Neuroblastoma, Oligodendroglioma, Pinealoma, Osteosarcoma, Teratoma, Testicular Neoplasms, Urologic Neoplasms, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Muscle Neoplasms, Optic Nerve Glioma, Genetic Diseases, Inborn, Histiocytoma, Malignant Fibrous

NCT01004978 2024-01-03

Chemoembolization With or Without Sorafenib Tosylate in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery

Phase 3 Completed

235 enrolled 12 charts

Carcinoma, Hepatocellular

NCT00019760 2023-10-31

Isolated Hepatic Perfusion With Melphalan Followed By Chemotherapy in Treating Patients With Unresectable Colorectal Cancer That is Metastatic to the Liver

Colonic Neoplasms, Gastrointestinal Neoplasms, Carcinoma, Hepatocellular, Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Genetic Diseases, Inborn

NCT02821754 2023-03-28

A Pilot Study of Combined Immune Checkpoint Inhibition in Combination With Ablative Therapies in Subjects With Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinomas (BTC)

54 enrolled 14 charts

Diabetes Mellitus, Insulin-Dependent, 12, Bile Duct Neoplasms, Biliary Tract Neoplasms, Carcinoma, Hepatocellular, Liver Neoplasms, Cholangiocarcinoma

NCT01015833 2022-08-04

Sorafenib Tosylate With or Without Doxorubicin Hydrochloride in Treating Patients With Locally Advanced or Metastatic Liver Cancer

Phase 3 Completed

356 enrolled 13 charts

Carcinoma, Hepatocellular

NCT00913757 2020-05-04

A Study of Molecular and Genetic Factors for Liver Cancer in the Greater Baltimore Area

1,871 enrolled

Hepatitis, Alcoholic, Hepatitis, Chronic, Hepatitis, Viral, Human, Carcinoma, Hepatocellular, Liver Cirrhosis, Alcoholic, Liver Neoplasms

NCT03748927 2020-03-26

Natural History Study of Children and Adults With Fibrolamellar Hepatocellular Carcinoma

Withdrawn

Carcinoma, Hepatocellular, Liver Neoplasms

NCT04025567 2020-03-16

Vancomycin in Patients With Unresectable Fibrolamellar Hepatocellular Carcinoma (FLC) Oral

Phase 2 Withdrawn

Carcinoma, Hepatocellular

NCT03217253 2020-02-07

Tazemetostat in Treating Patients With Metastatic or Unresectable Solid Tumors or B-Cell Lymphomas With Liver Dysfunction

Phase 1 Withdrawn

Carcinoma, Hepatocellular, Neoplasm Metastasis

NCT00341705 2019-12-17

The Second Multicenter Hemophilia Cohort Study

Classical hematologyGastrointestinalLymphoid

2,565 enrolled

Acquired Immunodeficiency Syndrome, Hemophilia A, Hepatitis C, Carcinoma, Hepatocellular, Lymphoma, Non-Hodgkin, Neoplasms, Hepatic Insufficiency

NCT00825877 2019-12-17

Long-term Follow-up of HALT-C Sustained Virological Responders

140 enrolled

Ascites, Death, Hepatitis C, Carcinoma, Hepatocellular

NCT01853618 2019-12-10

Tremelimumab With Chemoembolization or Ablation for Liver Cancer

61 enrolled 18 charts

Biliary Tract Neoplasms, Carcinoma, Hepatocellular, Liver Neoplasms

NCT00941655 2019-11-13

Prospective Randomized Trial Comparing Gastrectomy, Metastasectomy Plus Systemic Therapy Versus Systemic Therapy Alone: GYMSSA Trial

Phase 3 Completed

15 enrolled 18 charts

Carcinoma, Hepatocellular, Stomach Neoplasms

NCT02471313 2019-04-23

Integrated Imaging Strategy to Phenotype Progression of Liver Tumors During and After Chemoembolization

3 enrolled 5 charts

Carcinoma, Hepatocellular, Liver Neoplasms

NCT01010126 2019-01-25

Temsirolimus and Bevacizumab in Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer

GastrointestinalGynecologic

252 enrolled 20 charts

Fallopian Tube Neoplasms, Carcinoma, Hepatocellular, Ovarian Neoplasms, Somatostatinoma

NCT01306058 2019-01-23

Sorafenib and TRC105 in Hepatocellular Cancer

27 enrolled 32 charts

Carcinoma, Hepatocellular, Liver Neoplasms, Liver Neoplasms, Experimental, Adenoma, Liver Cell

NCT02599909 2018-09-20

Gut Microbiota in People With Hepatocellular Carcinoma (HCC)

Withdrawn

Carcinoma, Hepatocellular, Liver Neoplasms

NCT00101036 2018-04-20

Lapatinib in Treating Patients With Locally Advanced or Metastatic Biliary Tract or Liver Cancer That Cannot Be Removed By Surgery

57 enrolled 9 charts

Bile Duct Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular

NCT00459108 2018-04-19

Dasatinib in Treating Patients With Advanced Liver Cancer That Cannot Be Removed by Surgery

25 enrolled 7 charts

Carcinoma, Hepatocellular

NCT00321594 2017-11-06

Belinostat in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery

54 enrolled 8 charts

Carcinoma, Hepatocellular

NCT02042443 2017-09-12

S1310

53 enrolled 13 charts

Bile Duct Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Cholangiocarcinoma, Klatskin Tumor

NCT01375569 2017-07-28

TRC105 for Liver Cancer That Has Not Responded to Sorafenib

11 enrolled 10 charts

Carcinoma, Hepatocellular, Liver Neoplasms

NCT00085410 2017-07-02

Bortezomib in Treating Patients With Unresectable Locally Advanced or Metastatic Adenocarcinoma of the Bile Duct or Gallbladder

20 enrolled 13 charts

Bile Duct Neoplasms, Gallbladder Neoplasms, Gastrointestinal Neoplasms, Carcinoma, Hepatocellular

NCT01453283 2017-07-02

Tabectedin to Treat Children and Adolescents With Cancer

CNSGastrointestinalGenitourinarySarcoma

12 enrolled

Brain Neoplasms, Carcinoma, Hepatocellular, Neoplasms, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing

NCT01229111 2017-03-29

Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary Cancers

14 enrolled 11 charts

Bile Duct Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular

NCT00019604 2017-02-03

Radiofrequency Ablation in Treating Patients With Unresectable Primary or Metastatic Liver Cancer

44 enrolled 7 charts

Carcinoma, Hepatocellular, Liver Neoplasms, Neoplasm Metastasis

NCT00427973 2016-10-31

AZD2171 in Treating Patients With Locally Advanced Unresectable or Metastatic Liver Cancer

17 enrolled 7 charts