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Phase

Phase 3 4Phase 1/2 3Phase 2 2Phase 1 2Phase 4 1

Status

Completed 2Terminated 1

Sponsor Class

NIH 2INDUSTRY 1

Study Type

Interventional 3

Sponsor

Cancer Type

Head & Neck 1Endocrine 1

Conditions

Carcinoma, Medullary 3Thyroid Neoplasms 1Ovarian Neoplasms 1Neoplasms 1Neoplasm Metastasis 1Multiple Endocrine Neoplasia Type 2b 1Multiple Endocrine Neoplasia Type 2a 1Multiple Endocrine Neoplasia 1Gliosarcoma 1Glioblastoma 1Carcinoma, Renal Cell 1

Interventions

vandetanib 3selpercatinib 2rovalpituzumab tesirine 1pralsetinib 1Peripheral Blood Stem Cell Transplantation 1Indium 1Imatinib Mesylate 1Filgrastim 1Doxorubicin 1Dexamethasone 1Dacarbazine 1Capecitabine 1Calcium Aluminosilicate 1Bortezomib 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

3 trials
RecentStart dateEnrollment
Phase 1/2 × Carcinoma, Medullary × vandetanib × Clear all
NCT00514046 2020-12-22

Vandetanib to Treat Children and Adolescents With Medullary Thyroid Cancer

National Institutes of Health Clinical Center (CC)

Phase 1/2 Completed
17 enrolled 25 charts
Endocrine

Multiple Endocrine Neoplasia, Carcinoma, Medullary, Multiple Endocrine Neoplasia Type 2a, Multiple Endocrine Neoplasia Type 2b

NCT00923247 2018-11-29

A Targeted Phase I/II Trial of ZD6474 (Vandetanib; ZACTIMA) Plus the Proteasome Inhibitor, Bortezomib (Velcade ), in Adults With Solid Tumors With a Focus on Hereditary or Sporadic, Locally Advanced or Metastatic Medullary Thyroid Cancer (MTC)

National Institutes of Health Clinical Center (CC)

Phase 1/2 Terminated
22 enrolled 21 charts
Head & Neck

Neoplasms, Thyroid Neoplasms, Carcinoma, Medullary

NCT01661179 2016-12-05

Evaluate the Safety and Tolerability of Vandetanib in Japanese Patients With Medullary Thyroid Carcinoma

Sanofi

Phase 1/2 Completed
14 enrolled 7 charts

Neoplasm Metastasis, Carcinoma, Medullary

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