Announcements Trials
Browse Landscape

Phase

Phase 2 4Phase 1 2Phase 3 1

Status

Completed 5Active not recruiting 2

Sponsor Class

OTHER 10INDUSTRY 7NIH 2NETWORK 2

Study Type

Interventional 7

Sponsor

Cancer Type

Thoracic 7

Conditions

Carcinoma, Non-Small-Cell Lung 7Neurofibromatosis 1 6Neoplasm Metastasis 6Solid Tumours 5Neoplasms 5Melanoma 5Neurofibroma, Plexiform 4Lung Neoplasms 3Colorectal Neoplasms 3Breast Neoplasms 2Biliary Tract Neoplasms 2Uveal Melanoma 1Solid Tumors 1Renal Insufficiency 1Parkinson Disease 4, Autosomal Dominant Lewy Body 1Pancreatic Neoplasms 1Muscle Invasive Bladder Cancer 1Locally Advanced or Metastatic Solid Tumors 1Kidney Neoplasms 1Healthy Volunteers Pharmacokinetic Study 1Disease Progression 1Differentiated Thyroid Cancer 1Colonic Neoplasms 1Advanced Non Small Cell Lung Cancer 1Advanced Cancer 1

Interventions

Carboplatin 367Pemetrexed 308pembrolizumab 302Cisplatin 242Paclitaxel 230Docetaxel 199Gemcitabine 130Nivolumab 121Erlotinib Hydrochloride 114Bevacizumab 85osimertinib 78atezolizumab 65durvalumab 58Cetuximab 57130-nm albumin-bound paclitaxel 56Gefitinib 52Ipilimumab 46Afatinib 38Drug Therapy 33Cyclophosphamide 30Crizotinib 30Albumin-Bound Paclitaxel 30Vinorelbine 28cemiplimab 26tislelizumab 25avelumab 23icotinib 22Radiotherapy 22capmatinib 21Oxaliplatin 21

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

7 trials
RecentStart dateEnrollment
INDUSTRY × Carcinoma, Non-Small-Cell Lung × AZD 6244 × Clear all
NCT01933932 2025-11-19

SELECT-1

AstraZeneca

Phase 3 Active not recruiting
510 enrolled 16 charts
Thoracic

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT03944772 2025-01-30

ORCHARD

AstraZeneca

Phase 2 Active not recruiting
247 enrolled
Thoracic

Carcinoma, Non-Small-Cell Lung

NCT01750281 2023-10-24

SELECT-2

AstraZeneca

Phase 2 Completed
212 enrolled 12 charts
Thoracic

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT00890825 2018-06-20

AZD6244 in Combination With Docetaxel Versus Docetaxel Alone in KRAS Mutation Positive NSCLC Patients

AstraZeneca

Phase 2 Completed
88 enrolled 17 charts
Thoracic

Carcinoma, Non-Small-Cell Lung

NCT01809210 2018-03-13

SELECT-3

AstraZeneca

Phase 1 Completed
55 enrolled 21 charts
Thoracic

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT01605916 2016-10-21

Investigate the Safety and Tolerability of AZD6244 Monotherapy or + Docetaxel in Japanese Patients With Advanced Solid Malignancies or Non-Small Cell Lung Cancer

AstraZeneca

Phase 1 Completed
33 enrolled 24 charts
Thoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis, Neoplasms

NCT00372788 2014-08-13

AZD6244 Versus Pemetrexed (Alimta®) in Patients With Non-small Cell Lung Cancer, Who Have Failed One or Two Prior Chemotherapy Regimen

AstraZeneca

Phase 2 Completed
88 enrolled
Thoracic

Carcinoma, Non-Small-Cell Lung

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