Clinical Trials

Carcinoma, Non-Small-Cell Lung

NCT05802186 2026-05-15

Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study

Phase NA Recruiting

70 enrolled

Phase 3 Active not recruiting

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT04214262 2026-05-13

Testing the Addition of the Drug Atezolizumab to the Usual Radiation Treatment for Patients With Early Non-small Cell Lung Cancer

480 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT04716946 2026-05-11

Treating Early-stage Non-Small Cell Lung Cancer With Durvalumab and Radiation Therapy

13 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02206334 2026-05-07

Stereotactic Body Radiation Therapy in Treating Patients With Metastatic Breast Cancer, Non-small Cell Lung Cancer, or Prostate Cancer

BreastGenitourinaryThoracic

42 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Prostatic Neoplasms, Breast Neoplasms, Male

NCT06014827 2026-05-07

Biologically Guided Radiation Therapy (BgRT) and Stereotactic Body Radiation Therapy (SBRT) to Tyrosine Kinase Inhibitor in Oligoprogressive Oncogenic Positive Non-Small Cell Lung Carcinoma

32 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02417662 2026-05-06

SARON

140 enrolled

Carcinoma, Non-Small-Cell Lung

NCT04786093 2026-05-05

Durvalumab and Stereotactic Radiotherapy for Advanced NSCLC

Phase 2 Terminated

1 enrolled 12 charts

Carcinoma, Non-Small-Cell Lung

NCT05138900 2026-05-05

A Pilot Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) in Central Non-Small Cell Lung Cancer

BreastCNSDermatologicGenitourinaryThoracic

Carcinoma, Non-Small-Cell Lung

NCT06500455 2026-05-04

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

Phase 3 Recruiting

269 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Lung Neoplasms, Melanoma, Neoplasm Metastasis

NCT07565987 2026-05-04

APRIL

Phase NA Recruiting

Phase 1 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT04073745 2026-04-30

Single Fraction Stereotactic Body Radiation Therapy After Surgery in Treating Patients With Non-small Cell Lung Cancer

50 enrolled

Margins of Excision, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT07309952 2026-04-30

SACTION 2501

28 enrolled

Carcinoma, Non-Small-Cell Lung

NCT02839265 2026-04-28

FLT3

Phase 2 Completed

33 enrolled 10 charts

Carcinoma, Non-Small-Cell Lung

NCT05522660 2026-04-27

USZ-STRIKE

Phase 3 Recruiting

180 enrolled

DermatologicThoracic

Carcinoma, Non-Small-Cell Lung, Melanoma

NCT06623656 2026-04-21

Preoperative Radioimmunotherapy Versus Chemoimmunotherapy in NSCLC

112 enrolled

Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasms

NCT07535463 2026-04-17

A Study of Ivonescimab, Chemotherapy, and Stereotactic Radiosurgery for People With Non-Small Cell Lung Cancer

Phase 1/2 Recruiting

53 enrolled

Carcinoma, Non-Small-Cell Lung

NCT03110978 2026-04-16

Stereotactic Body Radiation Therapy With or Without Nivolumab in Treating Patients With Stage I-IIA or Recurrent Non-small Cell Lung Cancer

140 enrolled

EndocrineThoracic

Adenocarcinoma of Lung, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Carcinoma, Neuroendocrine

NCT06248606 2026-04-08

Adagrasib + SRS for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain Metastases

Phase 2 Not yet recruiting

Carcinoma, Non-Small-Cell Lung

NCT07517640 2026-04-08

Combining Furmonertinib With Local Therapy for Inoperable Early-stage Lung Cancer: A Phase II Trial

45 enrolled

Phase EARLY_PHASE1 Terminated

Carcinoma, Non-Small-Cell Lung

NCT03348748 2026-04-02

Stereotactic Body Radiation Therapy Followed by Surgery in Treating Patients With Stage I-IIIA Non-small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung

NCT03589547 2026-04-02

358

Phase 2 Completed

11 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02858869 2026-03-09

Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases

25 enrolled 14 charts

CNSDermatologicThoracic

Uveal Melanoma, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT01803542 2026-03-06

SBRT Lung

200 enrolled

Carcinoma, Non-Small-Cell Lung

NCT01345851 2026-02-25

Image-Guided Hypofractionated Radiation Therapy With Stereotactic Body Radiation Therapy Boost and Combination Chemotherapy in Treating Patients With Stage II-III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery

29 enrolled

Phase 3 Active not recruiting

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung

NCT03774732 2026-02-25

NIRVANA-LUNG

327 enrolled

Carcinoma, Non-Small-Cell Lung

NCT02984761 2026-02-19

Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Site, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Thoracic Neoplasms

NCT03965468 2026-02-09

CHESS

96 enrolled

Carcinoma, Non-Small-Cell Lung

NCT04081688 2026-02-05

Atezolizumab and Varlilumab in Combination With Radiation Therapy for NSCLC

Phase 1 Terminated

16 enrolled 9 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT03436056 2026-01-29

PRIMING

Phase 1 Terminated

2 enrolled 10 charts

Phase 1 Active not recruiting

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT03824327 2026-01-28

Papaverine and Stereotactic Body Radiotherapy (SBRT) for Non Small Cell Lung Cancer (NSCLC) or Lung Metastases

19 enrolled

Carcinoma, Non-Small-Cell Lung

NCT05830058 2026-01-05

Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma

DermatologicGenitourinaryThoracic

32 enrolled

Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Melanoma

NCT06877299 2026-01-02

Low-Dose Radiation + SBRT + Tislelizumab Plus Platinum-based Chemotherapy in Stage ⅡA-ⅢB Non-small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT07304739 2025-12-26

Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases

CNSThoracic

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT02314364 2025-12-16

A Trial of Integrating SBRT With Targeted Therapy in Stage IV Oncogene-driven NSCLC

Phase 2 Completed

27 enrolled 9 charts

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT03924869 2025-12-11

KEYNOTE-867

Phase 3 Terminated

448 enrolled 24 charts

Parkinson Disease 4, Autosomal Dominant Lewy Body, Carcinoma, Non-Small-Cell Lung

NCT07272356 2025-12-09

Evaluation of Efficacy of Minimally Invasive Local Therapy for Lung Tumors and Its Impact on Breathing Function

68 enrolled

Carcinoma, Non-Small-Cell Lung, Respiratory Aspiration

NCT03137771 2025-11-25

Maintenance Chemotherapy With or Without Local Consolidative Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer

218 enrolled 19 charts

Carcinoma, Non-Small-Cell Lung

NCT02599454 2025-10-27

Atezolizumab and Stereotactic Body Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung

NCT03307759 2025-09-15

SABRseq

Phase 1 Terminated

13 enrolled 14 charts

Carcinoma, Non-Small-Cell Lung

NCT06020066 2025-09-15

SRS for NSCLC With Oligo-residual Intracranial Disease After First-line 3rd Generation EGFR-TKI

202 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT03383302 2025-08-01

STILE

Phase 1/2 Completed

29 enrolled

Carcinoma, Non-Small-Cell Lung

NCT05486650 2025-07-14

An Observational Clinical Study of Stereotactic Radiotherapy for Advanced Non-Small Cell Lung Cancer With Stable Disease After PD-1 Inhibitor Treatment

Recruiting

Carcinoma, Non-Small-Cell Lung

NCT05319574 2025-06-12

SACTION01

46 enrolled

Carcinoma, Non-Small-Cell Lung

NCT06598527 2025-05-29

SACTION2401

Phase 3 Recruiting

360 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT04767009 2025-04-30

SBRT for Oligo-residual NSCLC After Treatment With PD-1/PD-L1 Immune Checkpoint Inhibitors

Phase 2 Unknown

59 enrolled

Carcinoma, Non-Small-Cell Lung

NCT03812549 2025-03-04

Safety and Tolerability Evaluation of Sintilimab in Combination With Radiation in Stage IV NSCLC Patients

29 enrolled 11 charts