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Recent Start date Enrollment

Phase EARLY_PHASE1 × Carcinoma, Squamous Cell × Pyrimethamine × Clear all

Phase

Phase EARLY_PHASE1 1

Status

Sponsor Class

Study Type

Interventional 1

Sponsor

Cancer Type

Conditions

Head and Neck Neoplasms 1 Carcinoma, Squamous Cell 1

Interventions

ruxolitinib 1 calcipotriene 1 RXDX-106 1 Pyrimethamine 1 Dimethyl Sulfoxide 1 Ascorbic Acid 1 3-(4-(2-fluoroethoxy)phenyl)-2-(3-methyl-2-(4-((2-sulfamoylbenzo(d)thiazol-6-yloxy)methyl)-1H-1,2,3-triazol-1-yl)butanamido)propanoic acid 1

Date Range

30 days 90 days 1 year All

Options

Has results Has announcements

NCT05678348 2025-08-17

Pyrimethamine as an Inhibitor of NRF2 in HPV-unrelated Locally Advanced Head and Neck Squamous Cell Carcinoma

Washington University School of Medicine

Phase EARLY_PHASE1 Completed

Carcinoma, Squamous Cell, Head and Neck Neoplasms

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