Clinical Trials Browser

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hearing Loss

NCT07513389 2026-05-20

Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)

Phase 2 Recruiting

36 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT07285044 2026-05-18

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

Phase 2 Recruiting

27 enrolled

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicLymphoidMyeloidPlasma cellThoracic

Amyloidosis, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Basal Cell, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Glioblastoma, Carcinoma, Hepatocellular, Hodgkin Disease, Lung Neoplasms, Melanoma, Multiple Myeloma, Myelodysplastic Syndromes, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Endometrial Neoplasms, Lymphoma, Mantle-Cell

NCT02133196 2026-05-13

T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer

Phase 2 Recruiting

85 enrolled

Thoracic

Adenocarcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Lung Neoplasms, Neoplasm Metastasis, Carcinoma, Adenosquamous

NCT05681039 2026-05-05

Phase 2 Trial of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab in Patients With Newly Diagnosed PD-L1 CPS Positive Resectable Stage 3-4 Oral Cavity Squamous Cell Carcinoma (OCSCC).

Phase 2 Recruiting

29 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT07419464 2026-04-27

5-Fluorouracil Response and Optimization STudy (The FROST Trial)

Phase 2 Recruiting

46 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Laryngeal Diseases

NCT07209189 2026-04-23

(NeoScorch HN)

Phase 2 Recruiting

75 enrolled

Head & Neck

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT06731933 2026-04-20

Impact of COL7A1 Gene Therapy on SCC Recurrence in RDEB Skin

Phase 2 Recruiting

16 enrolled

Tumor-Agnostic

Carcinoma, Squamous Cell

NCT02128906 2026-04-16

Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design

Phase 2 Recruiting

120 enrolled

Head & Neck

Carcinoma, Squamous Cell, Laryngeal Diseases

NCT07223424 2026-04-16

PSI-Immune

Phase 2 Recruiting

880 enrolled

DermatologicGastrointestinalGenitourinaryGynecologicThoracic

Adenocarcinoma Of Esophagus, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms, Colitis, Ulcerative, Colonic Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma

NCT06669572 2026-04-15

Lenvatinib and Pembrolizumab to Treat Patients With Anal or Rectum Cancer That Has Gotten Worse After Initial Treatment

Phase 2 Recruiting

35 enrolled

Tumor-Agnostic

Carcinoma, Squamous Cell

NCT05070403 2026-04-01

Study of Afatinib in Advanced Cutaneous Squamous Cell Carcinoma

Phase 2 Recruiting

25 enrolled

Dermatologic

Carcinoma, Squamous Cell, Skin Neoplasms

NCT06137274 2026-04-01

Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC

Phase 2 Recruiting

35 enrolled

Head & Neck

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT05027633 2026-03-20

Immunotherapy With Chemotherapy and Chemoradiation for Advanced Squamous Cancer of Nasal Cavity / Paranasal Sinuses (I-NAPA)

Phase 2 Recruiting

35 enrolled

Tumor-Agnostic

Carcinoma, Squamous Cell

NCT07435376 2026-02-27

INTLECTUAL

Phase 2 Recruiting

17 enrolled

Gynecologic

Carcinoma, Squamous Cell, Uterine Cervical Neoplasms

NCT06831149 2026-01-09

Use of SPY Imaging System to Minimize Fistulas After Hypopharyngeal Reconstruction

Phase 2 Recruiting

225 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT06940180 2025-06-26

Toripalimab With Chemotherapy for Sinus Cancer

Phase 2 Recruiting

20 enrolled

Head & Neck

Sinonasal undifferentiated carcinoma, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Paranasal Sinus Neoplasms

NCT05388773 2025-06-19

Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer

Phase 2 Recruiting

150 enrolled

Head & Neck

Carcinoma, Squamous Cell, DNA Virus Infections, Head and Neck Neoplasms, Stomatognathic Diseases, Neoplasms, Glandular and Epithelial, Oropharyngeal Neoplasms, Otorhinolaryngologic Diseases, Otorhinolaryngologic Neoplasms, Papilloma, Pharyngeal Diseases, Pharyngeal Neoplasms, Tumor Virus Infections, Papillomavirus Infections

NCT06869473 2025-03-14

AVEC-119

Phase 2 Recruiting

67 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT03708224 2025-01-28

Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck

Phase 2 Recruiting

55 enrolled

Head & Neck

Carcinoma, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Neoplasms

NCT05966194 2024-11-15

KEVLARx

Phase 2 Recruiting

216 enrolled

Head & NeckOther

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms, Stomatitis, Mucositis

NCT06577311 2024-08-29

Evaluating the Use of Photodynamic Therapy to Treat Facial Cutaneous Squamous Cell Carcinoma in Situ (SCCis)

Phase 2 Recruiting

20 enrolled

DermatologicGynecologic

Squamous Intraepithelial Lesions, Carcinoma, Squamous Cell, Skin Neoplasms

NCT05964101 2024-05-21

GALAXY-1

Phase 2 Recruiting

25 enrolled

Carcinoma, Squamous Cell, Neoplasms, Tracheal Neoplasms

NCT06383728 2024-05-09

GALAXY-02

Phase 2 Recruiting

51 enrolled

Thoracic

Carcinoma, Squamous Cell, Lung Neoplasms

NCT04894370 2023-12-22

SPARTANA

Phase 2 Recruiting

34 enrolled

Gastrointestinal

Anus Neoplasms, Carcinoma, Squamous Cell

NCT02290145 2023-11-22

Cyclin D1 Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at Clinical N2 Stage

Phase 2 Recruiting

48 enrolled

Head & Neck

Carcinoma, Squamous Cell, Mouth Neoplasms

NCT05252078 2022-12-16

ALTER-E005

Phase 2 Recruiting

30 enrolled

Gastrointestinal

Esophageal Squamous Cell Carcinoma, Carcinoma, Squamous Cell, Digestive System Diseases, Digestive System Neoplasms, Esophageal Diseases, Esophageal Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Squamous Cell

NCT04018872 2021-11-04

Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer

Phase 2 Recruiting

78 enrolled

Gastrointestinal

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Adenocarcinoma, Carcinoma, Squamous Cell, Esophageal Neoplasms

Clinical Trials

Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer

Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer

Phase 2 Trial of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab in Patients With Newly Diagnosed PD-L1 CPS Positive Resectable Stage 3-4 Oral Cavity Squamous Cell Carcinoma (OCSCC).

5-Fluorouracil Response and Optimization STudy (The FROST Trial)

(NeoScorch HN)

Impact of COL7A1 Gene Therapy on SCC Recurrence in RDEB Skin

Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design

PSI-Immune

Lenvatinib and Pembrolizumab to Treat Patients With Anal or Rectum Cancer That Has Gotten Worse After Initial Treatment

Study of Afatinib in Advanced Cutaneous Squamous Cell Carcinoma

Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC

Immunotherapy With Chemotherapy and Chemoradiation for Advanced Squamous Cancer of Nasal Cavity / Paranasal Sinuses (I-NAPA)

INTLECTUAL

Use of SPY Imaging System to Minimize Fistulas After Hypopharyngeal Reconstruction

Toripalimab With Chemotherapy for Sinus Cancer

Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer

AVEC-119

Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck

KEVLARx

Evaluating the Use of Photodynamic Therapy to Treat Facial Cutaneous Squamous Cell Carcinoma in Situ (SCCis)

GALAXY-1

GALAXY-02

SPARTANA

Cyclin D1 Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at Clinical N2 Stage

ALTER-E005

Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer