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Phase

Phase 2 73Phase 1 42Phase NA 38Phase 3 24Phase 1/2 17Phase 4 5Phase 2/3 3Phase EARLY_PHASE1 2

Status

Unknown 2Terminated 2Recruiting 2Completed 2Withdrawn 1Enrolling by invitation 1

Sponsor Class

OTHER 1INDUSTRY 1

Study Type

Interventional 2

Sponsor

Cancer Type

Head & Neck 2Thoracic 1Genitourinary 1Gastrointestinal 1

Conditions

Breast Neoplasms 97Prostatic Neoplasms 41Neoplasms 40Glioblastoma 26Melanoma 24Head and Neck Neoplasms 24Brain Neoplasms 24Ovarian Neoplasms 18Squamous Cell Carcinoma of Head and Neck 17Lung Neoplasms 17Carcinoma, Renal Cell 17Carcinoma, Hepatocellular 17Glioma 16Pancreatic Neoplasms 15Carcinoma, Non-Small-Cell Lung 15Leukemia, Myeloid, Acute 14Colorectal Neoplasms 14Precursor Cell Lymphoblastic Leukemia-Lymphoma 11Urinary Bladder Neoplasms 10Lymphoma 10Uterine Cervical Neoplasms 9Polycystic Ovary Syndrome 9Lymphoma, Non-Hodgkin 9Fallopian Tube Neoplasms 9Endometrial Neoplasms 9Myelodysplastic Syndromes 8Multiple Myeloma 8Lymphoma, Mantle-Cell 8Lymphoma, Large B-Cell, Diffuse 8Skin Neoplasms 7

Interventions

Pyrimethamine 13-(4-(2-fluoroethoxy)phenyl)-2-(3-methyl-2-(4-((2-sulfamoylbenzo(d)thiazol-6-yloxy)methyl)-1H-1,2,3-triazol-1-yl)butanamido)propanoic acid 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Phase EARLY_PHASE1 × Completed × Carcinoma, Squamous Cell × Clear all
NCT05678348 2025-08-17

Pyrimethamine as an Inhibitor of NRF2 in HPV-unrelated Locally Advanced Head and Neck Squamous Cell Carcinoma

Washington University School of Medicine

Phase EARLY_PHASE1 Completed
22 enrolled
Head & Neck

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT00884520 2010-03-16

VM4-037

Siemens Molecular Imaging

Phase EARLY_PHASE1 Completed
16 enrolled
GastrointestinalGenitourinaryHead & NeckThoracic

Hypoxia, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms

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