Clinical Trials

Phase 1 Active not recruiting

Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor

NCT05599984 2025-10-20

Study to Evaluate Adverse Events, Change in Disease Activity, and How ABBV-706 Moves Through the Body When Intravenously (IV) Infused Alone or in Combination With IV Infused Budigalimab, Cisplatin, or Carboplatin in Adult Participants With Advanced Solid Tumors

288 enrolled

CNSEndocrineThoracic

Neoplasms, Central Nervous System Neoplasms, Carcinoma, Neuroendocrine, Small Cell Lung Carcinoma

NCT04521686 2025-06-27

Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations

Phase 1 Active not recruiting

200 enrolled

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

Breast Neoplasms, Chondrosarcoma, Colonic Neoplasms, Glioblastoma, Glioma, Melanoma, Prostatic Neoplasms, Thyroid Neoplasms, Central Nervous System Neoplasms, Cholangiocarcinoma

NCT00085202 2024-02-08

Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor

416 enrolled 16 charts

Central Nervous System Neoplasms, Rhabdoid Tumor

NCT00003309 2023-06-22

Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer

33 enrolled

Ependymoma, Medulloblastoma, Central Nervous System Neoplasms

NCT00058370 2020-05-11

Intrathecal Radioimmunotherapy, Radiation Therapy, and Chemotherapy After Surgery in Treating Patients With Medulloblastoma

Phase NA Completed

6 enrolled 8 charts

Medulloblastoma, Central Nervous System Neoplasms

NCT00031590 2019-04-25

Low-Dose Radiation and Combination Chemotherapy Following Surgery in Children With Newly Diagnosed Medulloblastoma

Phase 2 Terminated

30 enrolled 5 charts

Brain Neoplasms, Medulloblastoma, Central Nervous System Neoplasms

NCT00085098 2018-09-07

Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor

24 enrolled 9 charts

Brain Neoplasms, Central Nervous System Neoplasms

NCT00470366 2017-11-28

Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors

CNSGenitourinaryGynecologic

60 enrolled 11 charts

Testicular Germ Cell Tumor, Dysgerminoma, Ovarian Neoplasms, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Carcinoma, Embryonal, Seminoma, Endodermal Sinus Tumor

NCT00003996 2016-12-07

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

93 enrolled

CNSSarcoma

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00003621 2016-07-14

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Anaplastic Astrocytoma

29 enrolled

Astrocytoma, Central Nervous System Neoplasms

NCT00084838 2015-12-24

Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT

25 enrolled 24 charts

CNSOther solid neoplasmSarcoma

Central Nervous System Neoplasms, Rhabdoid Tumor

NCT00003273 2015-12-03

Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor

Phase 2 Withdrawn

Neuroblastoma, Retinoblastoma, Sarcoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms

NCT00002875 2014-08-01

Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma

421 enrolled

Brain Neoplasms, Central Nervous System Neoplasms

NCT00003573 2014-07-25

Etoposide Plus Radiation Therapy Followed by Combination Chemotherapy in Treating Children With Newly Diagnosed Advanced Medulloblastoma

53 enrolled

Brain Neoplasms, Central Nervous System Neoplasms

NCT00053872 2014-06-24

Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma

Phase 3 Unknown

316 enrolled

Central Nervous System Neoplasms

NCT00003141 2014-03-28

Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors

Phase 1 Completed

94 enrolled

CNSSarcoma

Astrocytoma, Brain Neoplasms, Neuroblastoma, Sarcoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor

NCT00303810 2014-01-28

Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma

Phase NA Completed

567 enrolled

Central Nervous System Neoplasms

NCT00278278 2013-12-19

Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas

Phase 3 Unknown

150 enrolled

Astrocytoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT00392886 2013-12-18

Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors

Phase 3 Unknown

120 enrolled

Astrocytoma, Oligodendroglioma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor

NCT00281905 2013-09-20

Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors

50 enrolled

Astrocytoma, Neuroblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms

NCT00683319 2013-09-20

Observing Young Patients With Ependymoma Undergoing Standard Combination Chemotherapy

Active not recruiting

50 enrolled

Ototoxicity, Central Nervous System Neoplasms

NCT00276666 2013-09-17

Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Metastatic Medulloblastoma Who Have Undergone Surgery

29 enrolled

Central Nervous System Neoplasms

NCT00293358 2013-09-17

Combination Chemotherapy and Radiation Therapy in Treating Patients With Germ Cell Tumors in the Brain

500 enrolled

Central Nervous System Neoplasms

NCT00360945 2013-09-17

Cisplatin and Temozolomide in Treating Young Patients With Malignant Glioma

87 enrolled

Astrocytoma, Oligodendroglioma, Central Nervous System Neoplasms

NCT00003203 2013-08-23

Carboplatin and Vincristine Plus Radiation Therapy Followed By Adjuvant Chemotherapy in Treating Young Patients With Newly Diagnosed CNS Embryonal Tumors

168 enrolled

Brain Neoplasms, Neuroblastoma, Central Nervous System Neoplasms

NCT01172912 2013-08-12

High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy

47 enrolled

CNSGenitourinary

Testicular Germ Cell Tumor, Testicular Neoplasms, Central Nervous System Neoplasms

NCT00274911 2013-08-02

Radiation Therapy Followed By Combination Chemotherapy in Treating Young Patients With Supratentorial Primitive Neuroectodermal Tumors

30 enrolled

Central Nervous System Neoplasms

NCT00006258 2013-07-18

Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma

Ependymoma, Medulloblastoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive

NCT00002608 2013-07-10

Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors

CNSEndocrineGastrointestinalHead & NeckOther solid neoplasmSarcomaThoracic

30 enrolled

Familial ependymoma, Thyroid Cancer, Papillary, Mesothelioma, Malignant, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Liver Neoplasms, Medulloblastoma, Oligodendroglioma, Pheochromocytoma, Sarcoma, Thyroid Neoplasms, Central Nervous System Neoplasms, Adenocarcinoma, Follicular, Adrenocortical Carcinoma, Carcinoma, Medullary, Glioma, Subependymal, Gliosarcoma, Optic Nerve Glioma, Thyroid Carcinoma, Anaplastic

NCT00014573 2013-04-08

Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer

CNSSarcoma

Familial ependymoma, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Gliosarcoma

NCT00007982 2013-02-04

Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Patients With Central Nervous System Cancer