Clinical Trials Browser

Central Nervous System Neoplasms × Methotrexate × Clear all

NCT00602667 2026-05-19

Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma

Phase 2 Active not recruiting

293 enrolled 89 charts

Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor

NCT06466798 2026-01-08

Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS Malignancies

Phase 1 Withdrawn

Ependymoma, Medulloblastoma, Central Nervous System Neoplasms

NCT00082797 2023-06-15

High-Dose Methotrexate and Leucovorin in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Phase 2 Completed

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00621036 2018-11-26

Vaccine Therapy and GM-CSF in Treating Patients With CNS Lymphoma

Phase 2 Withdrawn

CNSDermatologicLymphoidOther hematologic neoplasm

Burkitt Lymphoma, Hodgkin Disease, Immunoblastic Lymphadenopathy, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Lymphoproliferative Disorders, Waldenstrom Macroglobulinemia, Mycosis Fungoides, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Central Nervous System Neoplasms, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Intraocular Lymphoma

NCT00068250 2018-02-07

Combination Chemotherapy, Monoclonal Antibody, and Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma

Phase 1/2 Completed

60 enrolled 10 charts

Lymphoma, Central Nervous System Neoplasms

NCT00397501 2017-04-21

BBBD Followed By Methotrexate and Carboplatin With or Without Trastuzumab in Treating Women With Breast Cancer That Has Spread to the Brain

Phase 1/2 Withdrawn

Brain Neoplasms, Breast Neoplasms, Central Nervous System Neoplasms, Drug-Related Side Effects and Adverse Reactions

NCT00084838 2015-12-24

Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT

Phase 2 Completed

25 enrolled 24 charts

Central Nervous System Neoplasms, Rhabdoid Tumor

NCT00003273 2015-12-03

Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor

Phase 2 Withdrawn

CNSOther solid neoplasmSarcoma

Neuroblastoma, Retinoblastoma, Sarcoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms

NCT00416819 2015-08-20

Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed Primary CNS Lymphoma

Phase NA Completed

Lymphoma, Central Nervous System Neoplasms

NCT00303810 2014-01-28

Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma

Phase NA Completed

Central Nervous System Neoplasms

NCT00278278 2013-12-19

Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas

Phase 3 Unknown

Astrocytoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT00392886 2013-12-18

Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors

Phase 3 Unknown

Astrocytoma, Oligodendroglioma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor

NCT00281905 2013-09-20

Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors

Phase 2 Unknown

Astrocytoma, Neuroblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms

NCT00683319 2013-09-20

Observing Young Patients With Ependymoma Undergoing Standard Combination Chemotherapy

Active not recruiting

Ototoxicity, Central Nervous System Neoplasms

NCT00287924 2013-09-17

High-Dose Methotrexate in Treating Young Patients With Residual Ependymoma

Phase 2 Unknown

Central Nervous System Neoplasms

NCT00006258 2013-07-18

Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma

Phase 2 Completed

Ependymoma, Medulloblastoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive

NCT00513981 2013-06-26

High-Dose Methotrexate in Treating Young Patients With Solid Tumors

Phase 1 Completed

Familial ependymoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms

NCT00463008 2013-06-24

Pharmacologic Study of Methotrexate in Patients Undergoing Stereotactic Biopsy for Recurrent High-Grade Glioma

Phase NA Completed

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00002463 2013-02-18

Combination Chemotherapy in Treating Children With Astrocytomas and Primitive Neuroectodermal Tumors

Phase 2 Completed

Astrocytoma, Central Nervous System Neoplasms

NCT00734773 2012-05-18

Pilot Study of MGd + High-dose MTX-Based Chemoimmunotherapy + RT for Newly Dx PCNSL

Phase EARLY_PHASE1 Withdrawn

Lymphoma, Central Nervous System Neoplasms, Neurotoxicity Syndromes