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Phase

Phase 2 9Phase NA 3Phase 3 2Phase 1/2 2Phase 1 2Phase EARLY_PHASE1 1

Status

Withdrawn 1Completed 1

Sponsor Class

OTHER 1NIH 1

Study Type

Interventional 2

Sponsor

Cancer Type

CNS 2Sarcoma 1

Conditions

Precursor Cell Lymphoblastic Leukemia-Lymphoma 25Leukemia, Myeloid, Acute 17Leukemia 11Myelodysplastic Syndromes 10Recurrence 8Lymphoma 8Burkitt Lymphoma 8Leukemia, Biphenotypic, Acute 7Multiple Myeloma 6Osteosarcoma 5Lymphoma, Non-Hodgkin 5Sarcoma 4Lymphoma, T-Cell 4Lymphoma, Large B-Cell, Diffuse 4Lymphoma, Follicular 4Hodgkin Disease 4Hematologic Neoplasms 4Primary Myelofibrosis 3Neoplasms, Plasma Cell 3Leukemia, Myeloid 3Leukemia, Lymphocytic, Chronic, B-Cell 3Waldenstrom Macroglobulinemia 2Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 2Lymphoma, Mantle-Cell 2Lymphoma, Large-Cell, Immunoblastic 2Lymphoma, B-Cell, Marginal Zone 2Leukemia, Myelomonocytic, Juvenile 2Leukemia, Myelomonocytic, Chronic 2Leukemia, Myelogenous, Chronic, BCR-ABL Positive 2Leukemia, Lymphoid 2

Interventions

Temozolomide 30Radiotherapy 23Filgrastim 12Carmustine 12Irinotecan 11Carboplatin 11Chemotherapy, Adjuvant 9O(6)-benzylguanine 8Etoposide 7Surgical Procedures, Operative 6Magnetic Resonance Spectroscopy 6Vincristine 5Peripheral Blood Stem Cell Transplantation 5Granulocyte Colony-Stimulating Factor 5Cyclophosphamide 5sargramostim 4motexafin gadolinium 4Topotecan 4Thiotepa 4Paclitaxel 4Melphalan 4Gene Expression Profiling 4Gemcitabine 4Drug Therapy 4Busulfan 4temsirolimus 3etoposide phosphate 3Specimen Handling 3Mass Spectrometry 3Imatinib Mesylate 3

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Phase 1 × Central Nervous System Neoplasms × Methotrexate × Clear all
NCT06466798 2026-01-08

Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS Malignancies

The University of Texas Health Science Center, Houston

Phase 1 Withdrawn
CNS

Ependymoma, Medulloblastoma, Central Nervous System Neoplasms

NCT00513981 2013-06-26

High-Dose Methotrexate in Treating Young Patients With Solid Tumors

National Cancer Institute (NCI)

Phase 1 Completed
36 enrolled
CNSSarcoma

Familial ependymoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms

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